2.A.6.2.33
Multidrug efflux pump, MexVW-OprM (exports fluoroquinolones, macrolides, chloramphenicol, tetracycline, erythromycin, ethidium bromide and acriflavine, and elevated ethidium bromide extrusion was observed (Li et al. 2003). MexAB-OprM and MexVW-OprM were both expressed at increased levels in the presence of elevated Ca2+ (Khanam et al. 2017).
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| Accession Number: | QKK87501.1 |
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| Protein Name: | QKK87501.1 multidrug efflux RND transporter permease subunit MexW [Pseudomonas aeruginosa] |
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| Length: | 1019 |
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| Molecular Weight: | |
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| Species: | Pseudomonas aeruginosa [287] |
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| Number of TMSs: | 12 |
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| Substrate |
macrolide, fluoroquinolone antibiotic, chloramphenicol, tetracycline, erythromycin A, 3,6-diamino-10-methylacridinium chloride, ethidium bromide |
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1: MAFTDPFIRR PVLASVVSLL IVLLGMQAFS KLVIREYPQM ENALITVTTL YAGANAETIQ
61: GYITQPLQQS LASAEGIDYM TSVSRQNYST ISIYARIGAN TDRLVTELLA KSNEVKSQLP
121: PDAEDPVLQK EAADASALMY ISFYSEQMNN PQITDYLSRV IQPKLATLPG IAEAEILGNQ
181: VFAMRLWLDP VKMAAFGVTA GEINQAVQQY NFLAAAGEVK GQLVVTSVNA STDLKSPQAF
241: AAIPVKTDGD RRVLMGDVAR VELGAASYDA ISSFNGIPSV YIGIKGTPSA NPLDVIKEVR
301: AKMPELEEQL PPNLKVSIAY DATRFIQASI DEVVKTLGEA VLIVIVVVFL FLGAFRSVLI
361: PVVTIPLSMI GVLFFMQAMG YSINLLTLLA MVLAIGLVVD DAIVVVENIH RHIEEGKPPF
421: EAALEGAREI AVPVVSMTIT LAAVYAPIGF LTGLTGALFK EFAFTLAGAV IISGIVALTL
481: SPMMCSRLLR HEENPSGLAH RLDLIFEGLK QRYQRALHGT LDTRPVVLVF AVLVLALIPV
541: LLMFTKKELA PEEDQGIVFL MTNSPQTANL DYLNRYTAEF EGIFRSFPEY YSAFQINGYN
601: GVQAGIGGML LKPWDEREKS QMELLHAVQA KLNEIPGVQI FAFNLPSLPG TGEGLPFQFV
661: LNTANDYESL LQVAQRVKQR ASESGKFAFL DLDLAFDKPE LVVDIDREKA AQMGVSMQDL
721: GVALASLLGE GEINRFTIDG RSYKVIAQVE RPYRDNPGWL GSYYVKSRNG QLVALSTLIE
781: THERARPRQL NQFQQLNSAI ISGFPIVSMG EAIETVQQIA REEAPRGFAV DYAGASRQYV
841: QEGSALLVTF GLALAIIFLV LAAQFESFRD PLVIMVTVPL SICGALIPLF LGVSSLNIYT
901: QVGLVTLIGL ISKHGILIVE FANQLRHEQG LGRREAIEQA AAIRLRPVLM TTAAMVLGVI
961: PLILATGAGA VSRFDIGIVI ATGMSVGTLF TLFVLPCIYT LVARPDAPPG VTQAANAH