1.A.1.11.35 Calcium channel of 2725 aas and 24 TMSs. T. cruzi calcium channels are inhibited by fendiline and bepridil (Reimão et al. 2011).
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Accession Number: | Q4DZ99 |
Protein Name: | Calcium channel protein, putative |
Length: | 2725 |
Molecular Weight: | 307293.00 |
Species: | Trypanosoma cruzi (strain CL Brener) [353153] |
Number of TMSs: | 22 |
Substrate |
calcium ion |
---|
1: MSGVPPAYPV DSNIGVPNAH TQQRLPASGS QSNTSSRVII GGVAPPTSTG RPHLPLPLPP
61: VKGAASQPPL TGTGSVPAPG HPPMGRLTPL QHRTLDGTEA QPGARPSPPP RLPMNSSTTQ
121: PTEASGAAEN GDGQSSAAGG LPTFHATINP LSPISQQEQL RQQRQHTPSR KTTDRAGTSS
181: ARSRKTMTPA SQQGTRPQSA ISGEETVEVL CPLPTQTRPV ERFFVEFNPG AIVGNGRDDN
241: AMYEEALLFD RLAEYTEDDS FFSSGSSVLE EDPRRLQKDI FRERAVRSVY DTLNLRALTG
301: GRTPQELEDK NRENAGWMYQ VHRRAIALHH SSFFVFPAGM KARVVTYNVL HHWLMELMIL
361: LIILGYSIFT ASWSRYGAPE FEKPDFMVFA DFLYTILYGI EIIARLFASG CILHSRAYFR
421: SPWHWLDTAV FVLMIMNCTQ WRDLWNFTAF RLIRIIKACT YLPLPIRMKI IAKSVLRSTC
481: KLFQTSIILV YALFFFALLG LQLFRGVLHY RCVNSLTGAA TSQLCRPEAT GHYWFYWGHV
541: CDPGYICISD GFPNPNYDFR SFDDVGHALL STFQIMTFQG WTSLLQETND AVTTLAFLYY
601: FFTILLCAWL IPGLFIGVFI EKIEKTSRLF EQKQLELFDA MLLEQRQRLT EAIKLRDFVE
661: RDECGRLRGH LAEAAPEDTS YPTLRVNSAS SNGKFPESGS FNSRNSERNT SVVTGSSGAA
721: KKRTKWTDEQ RVQLHLSLTR QRDIAEQGER RRRVIFKVDK KETDHTNGNF EMSSVSTNTT
781: NNMGGGDFAL GGRVGTVQHH PLTYTIGAAH GTRLPLAVRL ENEQERLQFL KYYQQAEEAD
841: DTTLQGGLTR GSRGVDGSTN NNMNSSHLSH SHPMRRGVGH GDEMGSDIIT IRESAGVIPN
901: RRSATTRGNT SGASTSLRTS TAAAAALNGS AGGVAQSQEI LIHDPEGGDF RYAKTFGQSW
961: GIIRNILHMF TEGCPRILTQ YLWEHRRMQT RFGLLPLNYV NKYEEAALRK LRQKRARRGK
1021: LILKNNRIED DGTDDYSEPE EPANEDQEYL GKLSPIRMAK NIVENAPVTL FSGIMLFLVF
1081: ANGVFNASRH YGQPVYWEDG LFIAGVCFTS LFMLELIIRF IVLGPGPFVC DFINVICVIV
1141: TVIGFFELGF GHSNTITVLN WVRFLRLFRI APFAPMRRVT RVFLLGFQDI VYALILFSVY
1201: MFMWILTGMS FFGGRFGRLT TQNDDYATIG FFDTFSHATF AVAQAFSYVR DEWLYLSWDG
1261: MRVRGGYTII YFLAVVFVAF IFRYLFIAVF AWAWQQQEER EDYVLHTTSK GGHQNRGGPR
1321: LHWFDFTVWR SFKHIHGGFE RRDVAPDEVF HLNQDMRRQL RIAEAKERFT RESMTRRGFS
1381: ADPQTIFSDS FSTNGNVASY GMPSSAPPLM LAPQFVNVGG QLQRQMSMPS TFDEPPPHPA
1441: QAPISRFQAE NAQLRFARRY SAVPATPYRG VAEELNGAHF LPVTSTPSDQ ALHNSNGSVA
1501: DTAAETEGLS HQIGGRASGL YGVHGSSNLP NEHHSSVTGY FTTLGYDKSG EKKNGEAMEN
1561: YQQSSENEEN GDPENSVVDG GGGGGGSGGV VYEHVLLPGP RLRYKHIMVG RHRRVFERCL
1621: DCNVHKQIPL RAPPNVQQRT ADELHAEHCH MAAVRSSRQL VLNTIIGYVR LQKELGGPPT
1681: REAVETVLGQ AWSCGMLLFE SIEYLSCADI ELREYRTWDR TLEALQLQQW LIGLHLGEEQ
1741: VGRATLAYIL AHQKTQERVA THSSFHRSWR DRSFFIFSPS HPARRFLTAI VESKWFEWFI
1801: LAVIFAASIC LCFYSPEDED RTSKKYLALH ILDDIFAIIF AVEMVLKWIS MGVVLDCHVA
1861: YFWHRWNTFD CFITIISLIA IAPKYSHFRF LKVMRCFRIL GPMRYCRFNK ELSKLALTMW
1921: DSVPTLVNVL LLFLLNYIVW SILALRLFMG LTHSCTSHAF SNKTSCEEAG AMWLGPQRNF
1981: DNFYESLLTM FEVSTGSRWL DVIYTGVDGW SMEFEPIYNR HPSKGLFFVA YYYVSHFVLF
2041: SLFVASLIYC YLLAKNAAEG VTDITFEHQL WLRMQRMILR LRPRVELVPL GNCLSRFLHR
2101: IVIHPAFELV MAGILLCNMI TMSLYWYGNS SRQEKALDIL EHLWVAFFTL EILMKLTAHG
2161: LRAFSRYSFC FQVFVTSLSY LQIGLNTTVG NHVPFNVNTL RLLHLGRMLK LVDFLVPVRH
2221: HLHLLHEALL LSASSLVNVT LILALAVFVF AVLGMHFIGP VVPVAGQYID DTYNNFRTFP
2281: NALMMIFRLA TLEDWVSMLR SSMSDGNNCP ISDCKTTNWA PVFYVPIVIC FALMIVNLYL
2341: AVVVDHYVTV VRMKASVARI NDLRRFRDLW SARDPNATLL LRTRKLPELL EALRPPLGLS
2401: SRKNRAELLR LLREYDIPDH GGKVHYYEVL LPLARRVLAM AFSEDEIDDG VKFEAVWRLS
2461: ESSLRALPTV LVHHSSATAA QHFAASYVQA AYRRDKACRK LHEMRANCWR EARRICDELG
2521: LPYKDYGFGD VSLEDEDPRN EAARRGLLNE STNEEKKQKN AADVTAAAAF AAAGRSESMT
2581: TDSNESSGKP APAARLPGLY QPAIDEKEKR FGPDVPHAVR RHETRSDKLR RKEEERQQQQ
2641: QQDPMDRQPS VPPAPRSTAQ RNQSIDYQPP LGTDPSEWLQ NEMGRRMSGA GAGTLSSANH
2701: TGAGGGASPT KATAPPSSEG LDGNV