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1.A.10.1.12
The NMDA receptor. The crystal structure of the N-terminal domains (GluN1 and GluN2) have been determined (PDB#3QEL; Talukder and Wollmuth, 2011). The ligand-specific deactivation time courses of GluN1/GluN2D NMDA receptors have been measured (Vance et al., 2011).  NMDA receptors are Hebbian-like coincidence detectors, requiring binding of glycine and glutamate in combination with the relief of voltage-dependent magnesium block to open an ion conductive pore. Lee et al. 2014 presented X-ray structures of the Xenopus laevis GluN1-GluN2B NMDA receptor with the allosteric inhibitor, Ro25-6981, partial agonists and the ion channel blocker, MK-801. Receptor subunits are arranged in a 1-2-1-2 fashion, demonstrating extensive interactions between the amino-terminal and ligand-binding domains. The 3-TMS transmembrane domains harbour a closed-blocked ion channel, a pyramidal central vestibule lined by residues implicated in binding ion channel blockers and magnesium, and a approximately twofold symmetric arrangement of ion channel pore loops. GRIN2D mediates developmental and epileptic encephalopathy (XiangWei et al. 2019).

Accession Number:Q91977
Protein Name:NMDA glutamate receptor subunit
Length:904
Molecular Weight:101894.00
Species:Xenopus laevis (African clawed frog) [8355]
Number of TMSs:3
Substrate ion

Cross database links:

DIP: DIP-59169N
Entrez Gene ID: 397953   
Pfam: PF01094    PF10562    PF00060    PF00497   
KEGG: xla:397953   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0030288 C:outer membrane-bounded periplasmic space
GO:0005886 C:plasma membrane
GO:0045211 C:postsynaptic membrane
GO:0005234 F:extracellular-glutamate-gated ion channel activity
GO:0004970 F:ionotropic glutamate receptor activity

References (2)

[1] “Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.”  Soloviev M.M.et.al.   8955083
[2] “A new type of ionotropic glutamate receptors”  Soloviev M.M.et.al.   8975675
Structure:
3QEK   3QEL   3QEM     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGTMRLFLLA VLFLFSFARA GCDPKIVNIG AVLSTKKHEQ IFREAVNQAN KRHFTRKIQL 
61:	NATSVTHRPN AIQMALSVCE DLISSQVYAI LVSHPPAPTD HLTPTPISYT AGFYRIPVIG 
121:	LTTRMSIYSD KSIHLSFLRT VPPYSHQALV WFEMMRLFNW NHVILIVSDD HEGRAAQKKL 
181:	ETLLEGKESK SKKRNYENLD QLSYDNKRGP KADKVLQFEP GTKNLTALLL EAKELEARVI 
241:	ILSASEDDAT AVYKSAAMLD MTGAGYVWLV GEREISGSAL RYAPDGIIGL QLINGKNESA 
301:	HISDAVAVVA QAIHELFEME NITDPPRGCV GNTNIWKTGP LFKRVLMSSK YPDGVTGRIE 
361:	FNEDGDRKFA NYSIMNLQNR KLVQVGIFNG SYIIQNDRKI IWPGGETERP QGYQMSTRLK 
421:	IVTIHQEPFV YVRPTTSDGT CREEYTINGD PIKKVICNGP NETIPGRPTV PQCCYGFCVD 
481:	LLIKLAREMN FTYEVHLVAD GKFGTQERVN NSNKKEWNGM MGELLSGQAD MIVAPLTINN 
541:	ERAQYIEFSK PFKYQGLTIL VKKEIPRSTL DSFMQPFQST LWLLVGLSVH VVAVMLYLLD 
601:	RFSPFGRFKV NSEEEEEDAL TLSSAMWFSW GVLLNSGIGE GAPRSFSARI LGMVWAGFAM 
661:	IIVASYTANL AAFLVLDRPE ERITGINDPR LRNPSDKFIY ATVKQSSVDI YFRRQVELST 
721:	MYRHMEKHNY ESAAEAIQAV RDNKLHAFIW DSAVLEFEAS QKCDLVTTGE LFFRSGFGIG 
781:	MRKDSPWKQN VSLNILKSHE NGFMEELDKT WVRYQECDSR SNAPATLTFE NMAGVFMLVA 
841:	GGIVAGIFLI FIEIAYKRHK DARRKQMQLA FAAVNVWRKN LQQYPPTDIT GQLNLSDPSV 
901:	STVV