TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.A.113.1.1 | The small integral membrane protein 22 of 81 aas and 1 TM | Eukaryota |
Metazoa, Chordata | Small integral membrane protein 22 of Stegastes partitus |
1.A.113.1.2 | Small integral membrane protein 5 isoform X1 of 119 aas and 1 TM | Eukaryota |
Metazoa, Chordata | Small integral membrane protein 5 isoform X1 of Anolis
carolinensis |
1.A.113.1.3 | ELN homologue of unknown function with 158 aas and 2 TMSs | Eukaryota |
Metazoa, Chordata | ELN homologue of Alligator mississippiensis (American alligator) |
1.A.113.1.4 | Small integral membrane DUF4713 protein 22 of 83 aas and 1 TMS | Eukaryota |
Metazoa, Chordata | Small membrane protein-22 of Sorex araneus |
1.A.113.1.5 | Small integral membrane protein 18 of 111 aas and 1 TMS | Eukaryota |
Metazoa, Chordata | Protein 18 of Phascolarctos cinereus |
1.A.113.2.1 | Uncharacterized protein of 112 aas and 1 TMS. | Eukaryota |
Metazoa, Chordata | UP of Scleropages formosus (Asian bonytongue) |
1.A.113.2.2 | Uncharacterized protein of 112 aas and 1 TMS. | Eukaryota |
Metazoa, Chordata | UP of Empidonax traillii |
1.A.113.2.3 | Uncharacterized protein of 108 aas and 1 TMS. | Eukaryota |
Metazoa, Chordata | UP of Electrophorus electricus (Electric eel) (Gymnotus electricus) |
1.A.113.3.1 | Uncharacterized protein of 109 aas and 1 TMS. | Eukaryota |
Metazoa, Arthropoda | UP of Apis mellifera |
1.A.113.3.2 | Uncharacterized protein of 77 aas and 1 TMS. | Eukaryota |
Metazoa, Arthropoda | UP of Anopheles gambiae (African malaria mosquito) |
1.A.113.3.3 | Uncharacterized protein of 84 aas and 1 TMS. | Eukaryota |
Metazoa, Arthropoda | UP of Harpegnathos saltator (Jerdon's jumping ant) |
1.A.113.3.4 | Uncharacterized protein of 81 aas and 1 TMS | Eukaryota |
Metazoa, Arthropoda | UP of Helicoverpa armigera |
1.A.113.3.5 | Uncharacterized protein of 97 aas and 1 TMS | Eukaryota |
Metazoa, Arthropoda | UP of Nasonia vitripennis (Parasitic wasp) |
1.A.113.3.6 | Uncharacteerized protein of 84 aas and 1 TMS | Eukaryota |
Metazoa, Arthropoda | UP of Nicrophorus vespilloides (Boreal carrion beetle) |
1.A.113.3.7 | Uncharacterized protein of 87 aas and 1 TMS | Eukaryota |
Metazoa, Arthropoda | UP of Laodelphax striatella (small brown planthopper) |
1.A.113.3.8 | Uncharacterized protein of 192 aas and 2 putative TMSs. | Eukaryota |
Metazoa, Arthropoda | UP of Folsomia candida (Springtail) |
1.A.113.5.1 | Endoregulin, ELN, also called small integral membrane protein-6, SMIM6, is of 62 aas and 1 TMS. This protein and the other members of the phospholamban family have been designated "micropeptides". Micropeptides function as regulators of calcium-dependent signaling in muscle. The sarco/endoplasmic reticulum Ca2+ ATPase (SERCA TC# 3.A.3.2.7), is the membrane pump that promotes muscle relaxation by taking up Ca2+ into the sarcoplasmic reticulum. It is directly inhibited by three known muscle-specific micropeptides: myoregulin (MLN), phospholamban (PLN) and sarcolipin (SLN). In non muscle cells, there are two other such micopeptides, endoregulin (ELN) and "another-regulin (ALN) (Anderson et al. 2016). Endoregulin is also known as "small integral membrane protein-6" (SMIM6) while ALN is also known as Protein C4 orf3 (C4orf3). These proteins share key amino acids with their muscle-specific counterparts and function as direct inhibitors of SERCA pump activity. The distribution of transcripts encoding ELN and ALN mirrored that of SERCA isoform-encoding transcripts in nonmuscle cell types. Thus, these two proteins are additional members of the SERCA-inhibitory micropeptide family, revealing a conserved mechanism for the control of intracellular Ca2+ dynamics in both muscle and nonmuscle cell types (Anderson et al. 2016). | Eukaryota |
Metazoa, Chordata | Endoregulin of Homo sapiens |
1.A.113.5.2 | ELN homologue of 78 aas and 1 TMS. | Eukaryota |
Metazoa, Chordata | ELN homologue of Nothobranchius furzeri |
1.A.113.5.3 | ELN homologue of 75 aas and 1 TMS. | Eukaryota |
Metazoa, Chordata | ELN of Larimichthys crocea (large yellow croaker) |
1.A.113.5.4 | Bacterial ELN homologue of unknown function with 101 aas and 1 TMS | Bacteria |
Thermodesulfobacteriota | ELN homologue of Desulfobacteraceae bacterium |
1.A.113.5.5 | ELN homologue of 85 aas and 1 TMS | Bacteria |
Thermotogota | ELN homologue of Thermotoga sp. |
1.A.113.5.6 | Small integral membrane protein 6 of 56 aas and 1 TMS, ELN. | Eukaryota |
Metazoa, Chordata | ELN of Mus musculus |