TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.113.1.1









The small integral membrane protein 22 of 81 aas and 1 TM

Eukaryota
Metazoa, Chordata
Small integral membrane protein 22 of Stegastes partitus
1.A.113.1.2









Small integral membrane protein 5 isoform X1 of 119 aas and 1 TM

Eukaryota
Metazoa, Chordata
Small integral membrane protein 5 isoform X1  of Anolis carolinensis
1.A.113.1.3









ELN homologue of unknown function with 158 aas and 2 TMSs

Eukaryota
Metazoa, Chordata
ELN homologue of Alligator mississippiensis (American alligator)
1.A.113.1.4









Small integral membrane DUF4713 protein 22 of 83 aas and 1 TMS

Eukaryota
Metazoa, Chordata
Small membrane protein-22 of Sorex araneus
1.A.113.1.5









Small integral membrane protein 18 of 111 aas and 1 TMS

Eukaryota
Metazoa, Chordata
Protein 18 of Phascolarctos cinereus
1.A.113.2.1









Uncharacterized protein of 112 aas and 1 TMS.

Eukaryota
Metazoa, Chordata
UP of Scleropages formosus (Asian bonytongue)
1.A.113.2.2









Uncharacterized protein of 112 aas and 1 TMS.

Eukaryota
Metazoa, Chordata
UP of Empidonax traillii
1.A.113.2.3









Uncharacterized protein of 108 aas and 1 TMS.

Eukaryota
Metazoa, Chordata
UP of Electrophorus electricus (Electric eel) (Gymnotus electricus)
1.A.113.3.1









Uncharacterized protein of 109 aas and 1 TMS.

Eukaryota
Metazoa, Arthropoda
UP of Apis mellifera
1.A.113.3.2









Uncharacterized protein of 77 aas and 1 TMS.

Eukaryota
Metazoa, Arthropoda
UP of Anopheles gambiae (African malaria mosquito)
1.A.113.3.3









Uncharacterized protein of 84 aas and 1 TMS.

Eukaryota
Metazoa, Arthropoda
UP of Harpegnathos saltator (Jerdon's jumping ant)
1.A.113.3.4









Uncharacterized protein of 81 aas and 1 TMS

Eukaryota
Metazoa, Arthropoda
UP of Helicoverpa armigera
1.A.113.3.5









Uncharacterized protein of 97 aas and 1 TMS

Eukaryota
Metazoa, Arthropoda
UP of Nasonia vitripennis (Parasitic wasp)
1.A.113.3.6









Uncharacteerized protein of 84 aas and 1 TMS

Eukaryota
Metazoa, Arthropoda
UP of Nicrophorus vespilloides (Boreal carrion beetle)
1.A.113.3.7









Uncharacterized protein of 87 aas and 1 TMS

Eukaryota
Metazoa, Arthropoda
UP of Laodelphax striatella (small brown planthopper)
1.A.113.3.8









Uncharacterized protein of 192 aas and 2 putative TMSs.

Eukaryota
Metazoa, Arthropoda
UP of Folsomia candida (Springtail)
1.A.113.5.1









Endoregulin, ELN, also called small integral membrane protein-6, SMIM6, is of 62 aas and 1 TMS.  This protein and the other members of the phospholamban family have been designated "micropeptides". Micropeptides function as regulators of calcium-dependent signaling in muscle. The sarco/endoplasmic reticulum Ca2+ ATPase (SERCA TC# 3.A.3.2.7), is the membrane pump that promotes muscle relaxation by taking up Ca2+ into the sarcoplasmic reticulum. It is directly inhibited by three known muscle-specific micropeptides: myoregulin (MLN), phospholamban (PLN) and sarcolipin (SLN). In non muscle cells, there are two other such micopeptides, endoregulin (ELN) and "another-regulin (ALN) (Anderson et al. 2016).  Endoregulin is also known as "small integral membrane protein-6" (SMIM6) while ALN is also known as Protein C4 orf3 (C4orf3).  These proteins share key amino acids with their muscle-specific counterparts and function as direct inhibitors of SERCA pump activity. The distribution of transcripts encoding ELN and ALN mirrored that of SERCA isoform-encoding transcripts in nonmuscle cell types. Thus, these two proteins are additional members of the SERCA-inhibitory micropeptide family, revealing a conserved mechanism for the control of intracellular Ca2+ dynamics in both muscle and nonmuscle cell types (Anderson et al. 2016).

Eukaryota
Metazoa, Chordata
Endoregulin of Homo sapiens
1.A.113.5.2









ELN homologue of 78 aas and 1 TMS.

Eukaryota
Metazoa, Chordata
ELN homologue of Nothobranchius furzeri
1.A.113.5.3









ELN homologue of 75 aas and 1 TMS.

Eukaryota
Metazoa, Chordata
ELN of Larimichthys crocea (large yellow croaker)
1.A.113.5.4









Bacterial ELN homologue of unknown function with 101 aas and 1 TMS

Bacteria
Thermodesulfobacteriota
ELN homologue of Desulfobacteraceae bacterium
1.A.113.5.5









ELN homologue of 85 aas and 1 TMS

Bacteria
Thermotogota
ELN homologue of Thermotoga sp.
1.A.113.5.6









Small integral membrane protein 6 of 56 aas and 1 TMS, ELN.

Eukaryota
Metazoa, Chordata
ELN of Mus musculus