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Mitochondrial cyclophilin D (CypD or Cyp3) or peptidyl-prolyl cis-trans isomerase F (PPIF) of 207 aas, possibly with one N-terminal TMS. It regulates formation of the mitochondrial permeable transition pore (mPTP) which consists of several proteins including those of the F-type ATPase and the outer mitochondrial membrane porins (VDACs) as well as other proteins (Dumbali and Wenzel 2022). Cyclophilin D is a mediator of axonal degeneration after intracerebral hemorrhage (Yang et al. 2023). The abnormal opening of mitochondrial permeability transition pore (mPTP) induces the loss of the mitochondrial membrane potential, the impairment of calcium homeostasis and a decrease of ATP production. Cyclophilin D (CypD), localized in the mitochondrial transition pore, and is a mitochondrial chaperone that is a prominent mediator of mPTP (Zhou et al. 2023).

Metazoa, Chordata
CypD of Homo sapiens