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1.A.2.1.11
Inward rectifying potassium channel 16, Kir5.1 or KCNJ16. (Potassium channel subfamily J member 16).  Involved in pH and fluid regulation.  Forms heteromers with Kir4.1/KCNJ10 or Kir2.1/KCNJ2. MAGI-1 anchors Kir4.1 channels (Kir4.1 homomer and Kir4.1/Kir5.1 heteromer) and contributes to basolateral K+ recycling. The Kir4.1 A167V mutation is associated with EAST/SeSAME syndrome caused by mistrafficking of the mutant channels and inhibiting their expression on the basolateral surface of tubular cells. These findings suggest that mislocalization of the Kir4.1 channels contributes to renal salt wasting. (Tanemoto et al. 2014).

Accession Number:Q9NPI9
Protein Name:Inward rectifier potassium channel 16
Length:418
Molecular Weight:47949.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Entrez Gene ID: 3773   
Pfam: PF01007   
KEGG: hsa:3773   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005242 F:inward rectifier potassium channel activity
GO:0007268 P:synaptic transmission

References (2)

[1] “The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.”  Liu Y.et.al.   11060447
[2] “Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.”  Derst C.et.al.   11240146

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 
61:	IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 
121:	AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 
181:	TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 
241:	VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 
301:	PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR 
361:	ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM