1.A.2.1.11
Inward rectifying potassium channel 16, Kir5.1 or KCNJ16. (Potassium channel subfamily J member 16). Involved in pH and fluid regulation. Forms heteromers with Kir4.1/KCNJ10 or Kir2.1/KCNJ2. MAGI-1
anchors Kir4.1 channels (Kir4.1 homomer and Kir4.1/Kir5.1 heteromer) and
contributes to basolateral K+ recycling. The Kir4.1 A167V mutation
is associated with EAST/SeSAME syndrome caused by mistrafficking of the mutant
channels and inhibiting their expression on the basolateral surface of
tubular cells. These findings suggest that mislocalization of the Kir4.1
channels contributes to renal salt wasting.
(Tanemoto et al. 2014).
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| Accession Number: | Q9NPI9 |
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| Protein Name: | Inward rectifier potassium channel 16 |
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| Length: | 418 |
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| Molecular Weight: | 47949.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
potassium(1+) |
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| Entrez Gene ID: |
3773
|
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| Pfam: |
PF01007
|
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| KEGG: |
hsa:3773
|
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[1] “The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.” Liu Y. et.al. 11060447
[2] “Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.” Derst C. et.al. 11240146
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1: MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD
61: IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG
121: AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ
181: TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL
241: VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
301: PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR
361: ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM