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Accession Number: | Q14500 |
Protein Name: | ATP-sensitive inward rectifier potassium channel 12 |
Length: | 433 |
Molecular Weight: | 49001.00 |
Species: | [9606] |
Number of TMSs: | 3 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | potassium(1+) |
Cross database links:
RefSeq: | NP_066292.2 XP_001718688.2 XP_002347768.1 |
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Entrez Gene ID: | 100131509 100290070 3768 |
Pfam: | PF01007 PF08466 |
OMIM: |
602323 gene |
KEGG: | hsa:100131509 hsa:100290070 hsa:3768 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005242
F:inward rectifier potassium channel activity
GO:0008200
F:ion channel inhibitor activity
GO:0015459
F:potassium channel regulator activity
GO:0008015
P:blood circulation
GO:0006936
P:muscle contraction
GO:0006813
P:potassium ion transport
GO:0008016
P:regulation of heart contraction
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References (6)[1] “Cloning and functional expression of an inwardly rectifying K+ channel from human atrium.” Wible B.A.et.al. 7859381 [2] “Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.” Namba N.et.al. 8647284 [3] “Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes.” Kaibara M.et.al. 12417321 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MTAASRANPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIEFANM 61: DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGI IFWVIAVAHG DLEPAEGRGR 121: TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI 181: MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE 241: GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE 301: GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK 361: DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG 421: VLEQRPYRRE SEI