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1.A.2.1.9
The inward-rectifier K+ channel, Kir2.2, KCNJ12, KCNJN1, KCNJ18, IRK2, of 433 aas and 2 TMSs. The 3-d structure at 3.1 Å resolution is available (Tao et al., 2009). (It is 70% identical to Kir2.1 (TC # 1.A.2.1.2)). The structural basis of PIP2 activation of Kir2.2 has been presented (Hansen et al., 2011). Inward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved in maintaining resting membrane potential and signal transduction in most cells, as well as connecting metabolism and membrane excitability of body cells. It is closely related to normal physiological functions of body and the occurrence and development of some diseases. The functional expression of Kir channels in vascular endothelial cells and smooth muscle cells and their changes in disease states were reviewed, especially the recent research progress of Kir channels in stem cells was introduced, in order to have a deeper understanding of Kir channels in vascular tissues and provide new ideas and directions for the treatment of related ion channel diseases (Li and Yang 2023).

Accession Number:Q14500
Protein Name:ATP-sensitive inward rectifier potassium channel 12
Length:433
Molecular Weight:49001.00
Species: [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate potassium(1+)

Cross database links:

RefSeq: NP_066292.2    XP_001718688.2    XP_002347768.1   
Entrez Gene ID: 100131509    100290070    3768   
Pfam: PF01007    PF08466   
OMIM: 602323  gene
KEGG: hsa:100131509    hsa:100290070    hsa:3768   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0008200 F:ion channel inhibitor activity
GO:0015459 F:potassium channel regulator activity
GO:0008015 P:blood circulation
GO:0006936 P:muscle contraction
GO:0006813 P:potassium ion transport
GO:0008016 P:regulation of heart contraction

References (6)

[1] “Cloning and functional expression of an inwardly rectifying K+ channel from human atrium.”  Wible B.A.et.al.   7859381
[2] “Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.”  Namba N.et.al.   8647284
[3] “Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes.”  Kaibara M.et.al.   12417321
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene.”  Gallagher P.G.et.al.   9430667
[6] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTAASRANPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIEFANM 
61:	DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGI IFWVIAVAHG DLEPAEGRGR 
121:	TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI 
181:	MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE 
241:	GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE 
301:	GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK 
361:	DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG 
421:	VLEQRPYRRE SEI