1.A.23.3.4
MscCG2 of 334 aas and 4 TMSs in a 3 + 1 arrangement. It functions as an L-glutamate exporter and an osmotic safety valve (Wang et al. 2018). It is 23% identical to MscCG (TC# 1.A.23.3.3) in the same organism. MscCG2-mediated L-glutamate excretion was activated by biotin limitation or penicillin treatment, and constitutive L-glutamate excretion was triggered by a gain-of-function mutation (A151V). It was not induced by glutamate producing conditions (Wang et al. 2018).
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| Accession Number: | WP_004567541.1 |
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| Protein Name: | WP_004567541.1 MULTISPECIES: mechanosensitive ion channel family protein [Corynebacterium] |
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| Length: | 335 |
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| Molecular Weight: | |
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| Species: | Corynebacterium [1716] |
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| Number of TMSs: | 4 |
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| Substrate |
L-glutamate(1-) |
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1: MIIASTDTES IVTDVSNWWD NPLTQDWLIN KPISIAITIV VAFFAHWLLR KLITKAVERG
61: VRKPPKTEVP RFLVKGQAKK TDIPPEVQIM RKTQEQRRQA RIRTLGAVGK SAVAIFVWTW
121: AALAILTEIG LNVAPLIASA GVAGVALGFG AQSLVKDFLS GIFMLIEDQY GVGDTIDVGD
181: GIIGDVEDIS LRTTTLRDLD GTVWYIRNGE ILRVGNFSNE YAIARFEVPV GLSNDSDRAW
241: DVIENSFQEA VKMEAIKDSV IDTPEMKGIS AFEPDHMTFR GVVKTLPGYQ WEVQRYVYAK
301: VLSDMQKEGI TTPYPHGMGG VGLAQQTLDK GDAN