1.A.24.1.12
Connexin 29 (Cx29, Gjc3, Gje1) of 269 aas and 4 TMSs. The Cx29E269D mutant has a dominant negative effect on the formation and function
of gap junctions, explaining the role Cx29 in the development of hearing loss (Hong et al. 2010). Direct axon-to-myelin linkage by abundant KV1 (TC# 1.A.1.2.10 and 12)/Cx29 channel interactions in rodent axons supports the idea of an electrically active role for myelin in increasing both the saltatory
conduction velocity and the maximal propagation frequency in mammalian myelinated axons (Rash et al. 2016).
|
| Accession Number: | Q921C1 |
|---|
| Protein Name: | Gap junction gamma-3 protein |
|---|
| Length: | 269 |
|---|
| Molecular Weight: | 30293.00 |
|---|
| Species: | Mus musculus (Mouse) [10090] |
|---|
| Number of TMSs: | 4 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
molecule |
|---|
1: MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS GPGVFGNDEN
61: EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA IYVAFTLYHV IGYWEVPGKE
121: NKEQETQISK GDHSKDVSGA KSLKLLWAYV AHLGVRLALE GAALGVQYNL YGFKMSSTFI
181: CREDPCIGST TCFQSHPSEK TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF
241: LKKLPTSESS VRSKDTTDEL SVVEAKEPF