1.A.24.1.14
Gap junction protein B4, GJB4, or Cx30.3 of 266 aas and 4 TMSs. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore in these dodecameric channels. Mutation can cause a familial form of hypertrophic cardiomyopathy (HCM) and therefore could be a target for the treatment of cardiac hypertrophy and dysfunction (Okamoto et al. 2020). Cx30 and Cx26 hemichannels display similar permeabilities to ATP, but Cx26 gap junctions are six times more permeable than their hemichannels and four times more permeable than Cx30 gap junctions (Xu and Nicholson 2023).
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| Accession Number: | Q9NTQ9 |
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| Protein Name: | Gap junction beta-4 protein |
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| Length: | 266 |
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| Molecular Weight: | 30419.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion, organic molecule, signalling molecule |
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1: MNWAFLQGLL SGVNKYSTVL SRIWLSVVFI FRVLVYVVAA EEVWDDEQKD FVCNTKQPGC
61: PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE RERKHHLKHG PNAPSLYDNL
121: SKKRGGLWWT YLLSLIFKAA VDAGFLYIFH RLYKDYDMPR VVACSVEPCP HTVDCYISRP
181: TEKKVFTYFM VTTAAICILL NLSEVFYLVG KRCMEIFGPR HRRPRCRECL PDTCPPYVLS
241: QGGHPEDGNS VLMKAGSAPV DAGGYP