1.A.24.1.15
Gap junction protein alpha 5, GJA5 or CxA5, of 358 aas and 4 TMSs. One
gap junction consists of a cluster of closely packed pairs of
transmembrane channels, the connexons, through which materials of low MW
diffuse from one cell to a neighboring cell. GAJ5 is enriched for the function of ion transmembrane transport regulation and is a key atrial fibrillation (AF)-valvular heart disease (VHD) protein (Zhao et al. 2021).
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| Accession Number: | P36382 |
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| Protein Name: | Gap junction alpha-5 protein |
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| Length: | 358 |
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| Molecular Weight: | 40380.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGDWSFLGNF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AESSWGDEQA DFRCDTIQPG
61: CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV RMQEKRKLRE AERAKEVRGS
121: GSYEYPVAEK AELSCWEEGN GRIALQGTLL NTYVCSILIR TTMEVGFIVG QYFIYGIFLT
181: TLHVCRRSPC PHPVNCYVSR PTEKNVFIVF MLAVAALSLL LSLAELYHLG WKKIRQRFVK
241: PRQHMAKCQL SGPSVGIVQS CTPPPDFNQC LENGPGGKFF NPFSNNMASQ QNTDNLVTEQ
301: VRGQEQTPGE GFIQVRYGQK PEVPNGVSPG HRLPHGYHSD KRRLSKASSK ARSDDLSV