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1.A.25.2.3
Pannexin-3, PANX3, of 392 aas and 5 TMSs, is reported to form functional, single membrane, cell surface channels (Penuela et al., 2007)). It functions as an ER Ca2+ channel, hemichannel, and gap junction to promote osteoblast differentiation (Ishikawa et al., 2011). However, Panx3 expression in osteoblasts is not required for postnatal bone remodeling (Yorgan et al. 2019).  PANX3 contributes to various developmental and pathophysiological processes by permeating ATP and Ca2+ ions.  The cryo-EM structure of human PANX3 has been solved at 2.9-3.2 Å (Tsuyama et al. 2025). The PANX3 channel is heptameric and forms a transmembrane pore along the central symmetric axis. The narrowest constriction of the pore is composed of an isoleucine ring located in the extracellular region, and its size is comparable to that of other pannexins.

Accession Number:Q96QZ0
Protein Name:Pannexin-3 aka PANX3
Length:392
Molecular Weight:44683.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate calcium(2+), ATP

Cross database links:

RefSeq: NP_443191.1   
Entrez Gene ID: 116337   
Pfam: PF00876   
OMIM: 608422  gene
KEGG: hsa:116337   

Gene Ontology

GO:0005921 C:gap junction
GO:0016021 C:integral to membrane

References (1)

[1] “The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins.”  Baranova A.et.al.   15028292

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM SLAFAQEFSS 
61:	GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK MKSLWPHKAL PYSLLALALL 
121:	MYLPVLLWQY AAVPALSSDL LFIISELDKS YNRSIRLVQH MLKIRQKSSD PYVFWNELEK 
181:	ARKERYFEFP LLERYLACKQ RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF 
241:	SCSIKTGLLS DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR 
301:	LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC VLKDTTTQKH 
361:	NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP