1.A.25.2.3 Pannexin-3, PANX3, of 392 aas and 5 TMSs, is reported to form functional, single membrane, cell surface channels (Penuela et al., 2007)). It functions as an ER Ca2+ channel, hemichannel, and gap junction to promote osteoblast differentiation (Ishikawa et al., 2011). However, Panx3 expression in osteoblasts is not required for postnatal bone remodeling (Yorgan et al. 2019). PANX3 contributes to various developmental and pathophysiological processes by permeating ATP and Ca2+ ions. The cryo-EM structure of human PANX3 has been solved at 2.9-3.2 Å (Tsuyama et al. 2025). The PANX3 channel is
heptameric and forms a transmembrane pore along the central symmetric
axis. The narrowest constriction of the pore is composed of an
isoleucine ring located in the extracellular region, and its size is
comparable to that of other pannexins.
|
Accession Number: | Q96QZ0 |
Protein Name: | Pannexin-3 aka PANX3 |
Length: | 392 |
Molecular Weight: | 44683.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
calcium(2+), ATP |
---|
1: MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM SLAFAQEFSS
61: GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK MKSLWPHKAL PYSLLALALL
121: MYLPVLLWQY AAVPALSSDL LFIISELDKS YNRSIRLVQH MLKIRQKSSD PYVFWNELEK
181: ARKERYFEFP LLERYLACKQ RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF
241: SCSIKTGLLS DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR
301: LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC VLKDTTTQKH
361: NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP