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1.A.25.2.4
Pannexin 1a, Panx1a, of 417 aas and 4 TMSs, an ATP channel.  Aromatic-aromatic interaction involving Trp123 and Tyr205 in TMSs 2 and 3, respectively are important for the assembly and trafficking of the Zebrafish Panx1a membrane channel (Timonina et al. 2020).

Accession Number:Q7ZUN0
Protein Name:Pannexin
Length:417
Molecular Weight:46955.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAIAHAATEY VFADFVLKDP ASENRYKGIR LDLALDKIVT CVAVGLPLLL ISLAFAQEVS 
61:	VGTQISCFAP TAFSWCQAAY VDSYCWAAVQ KQDTGGLPLW LHKFFPYILL LVAVSVYMPA 
121:	LFWRFTGAPV LSSDLTFIME ELDRSYNRAI KLAKCLHTAG KVETPPAPVD TNSSVIDLTE 
181:	SYFKYPLVEQ YLRTKRYSKG LLIRYLLCRT ITVLALTLAC IYLCYYISLS TTDEFSCDIR 
241:	SGVVVNDSSV PPALQCKLVA VGIFQLLSYI NLSVYLLLLP LCMFAMLVPF RRTKGFLKPF 
301:	EMLPTIGVMQ FGQATWDDLA LYLLFLEENL SELKSYKCLK VLELLKEQGD ESFDPMLLLR 
361:	TLGQVKTDVV DGRLPQKDQK ISSTNNGDTE LKEFAPLLPE DCLRKHEDEK AVRQRVI