1.A.3.1.10 Ryanodine receptor, RyR, of 5139 aas and 6 TMSs. Sensitive to the diamide insecticides, chlorantraniliprole and flubendiamide. It has the conserved C-terminal domain with the consensus calcium-biding EF-hands (calcium-binding motif), the six transmembrane domains, as well as mannosyltransferase, IP3R and RyR (pfam02815) (MIR) domains (Wu et al. 2018). Probably transports monovalent cations and Ca2+.
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Accession Number: | AXA98483.1 |
Protein Name: | AXA98483.1 Ryanodine receptor [Sesamia inferens] |
Length: | 5140 |
Molecular Weight: | |
Species: | Sesamia inferens [492764] |
Number of TMSs: | 4 |
Substrate |
calcium ion, monoatomic monocation |
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1: MAESEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFPEN IADKNIPPDL
61: SQCVFVIEQA LSVRALQELV TAAGSETGKG TGSGHRTLLY GNAILLRHLN SDMYLACLST
121: SSSQDKLAFD VGLQEHSQGE ACWWTLHPAS KQRSEGEKVR VGDDLILVSV ATERYLHTTK
181: ENEVSIVNAS FHVTHWSVQP YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSTWTKDG
241: GQNIVVYEGG SVMSRARSLW RLELARTKWA GGSINWYHPM RIRHITTGRY LGVNDQNELY
301: LVSREEATTA SCAFCLRQEK DDQKQVLEDK DLEVIGAPII KYGDSTVIVQ HSETGLWLSY
361: KSYETKKKGV GKVEEKQAIL HEEGKMDDGL DFSRSQEEES RTARVIRKCS SLFTKFINGL
421: ETLQENRRHS MFFASVNLGE MVMCLEDLIN YFAQPDDDME HEEKQNRFRA LRNRQDLFQE
481: EGILNLILEA IDKINVITSQ GFLAGFLAGD ESGQSWEMIS GYLYQLLAAI IKGNHTNCAQ
541: FANSNRLNWL FSRLGSQASG EGTGMLDVLH CVLIDSPEAL NMMRDEHIKV IISLLEKHGR
601: DPKVLDVLCS LCVGNGVAVR SSQNNICDYL LPGKNLLLQT ALVDHVSSVR PNIFVGRVEG
661: SAVYRKWYFE VTMDHIEKTT HMMPHLRIGW ANTTGYVPYP GGGEKWGGNG VGDDLYSYGF
721: DGAYLWSGGR KTMVNRTHQE EPYIRKGDVI GCALDLTVPI INFMFNGMRV TGSFTNFNLE
781: GMFFPVISCS SKLSCRFLLG GEHGRLRYAA PEGYSPLVES LLPQQILSLE PCFYFGNLSK
841: RALAGPPLVQ DDTAFVPTPV DTIQITLPSY VEQIRDKLAE NIHEMWAINK IEAGWMYGDQ
901: REDLHKIHPC LVPFERLPPA EKRYDIQLAV QTLKTILALG YYISLDKPPA RIRNVRLPNE
961: PFMQSNGYEP APLDLSAVTL TPKMDELVDQ LAENTHNLWA RERIQQGWTY GLNEDPDMHR
1021: SPHLVPYPKV DDAIKKANRD TASETVRTLL VYGYMLDPPT GEQHEALLLE ASKQKQADFR
1081: TYRAEKNYAV GSGKWYFEFE ILTAGPMRVG WAHADMAPGM MLGQDENSWA FDGYNEEKVY
1141: SGSTESFGKQ WAVGDVVGVF LDLIDKTISF SLNGELLMDA LGGETTFADV QGDNFVPACT
1201: LGVGQKARLT YGQDVNTLKY FTTCGLQEGY EPFCVNMKRD VTHWYTKDQP IFENTDEMTD
1261: TGIDVTRIPA GSDTPPCLKI SHNTFETMEK ANWEFLRLSL PVICHLEFID ESEKARRWIE
1321: IKERQQILMK EAVEAQMPAH IDQIMRSGFT MNDIKGMHYE DNQEEMPTSS KAKRLPSRPP
1381: RKGSVTRGVS IQNYNNLQTG PQVNGMHRST SEAEMAKYEL GAQNLAPDDK KDKRGRSPFK
1441: FFRSKRGESN DRGKSRKSKT PDPFSDTEVS PERGPRRPNP QIKVSQANQK YNGMNARPSR
1501: ANLYGSQAGL NMATPTQDRK QMTTSTLAQS ATETVGNEIF DAECLKLINE YFYGVRIYPG
1561: QDPTHVYIGW VTTQYHLHSK DFNQSKVTKS SVIITDDYDR IIENVNRQSC YMVRADELYN
1621: EVMAEATAKG ASQGMFIGCS VDTSTGTVSF TCEGKDTSIK FKMEPETKLF PAIFVEATSK
1681: EILQIELGRS TTSLPLSAAV LPTSDKHVIP QFPPRLKVQC LSPHQWARVP NQSLQVHALK
1741: LSDIRGWSML CEDAVSMLAL HIPEEDRCID ILELIETDKL LSFHSHTLTL YAALCYQSNY
1801: RAAHALCTHV DQKQLLYAIQ SQYMSGPLRQ GFYDLPIALH LESHATTMEA CKNEFVIPLG
1861: PELKSLYEDP DMGHSLRSLQ TESVCPQMKM TDIAESITEI SNLYSPYFPL EVVREFVMQA
1921: LAEAVETNQV HNRDPVGGSN ENLFLPLIKL VDRLLLVGMM RDEDVEKLLI MINPETWDPS
1981: FDREGKDEHR KGLLHMKMAE GAKLQMCYLL QHLNDIQLRH RVEAIIAFAH DFVGDLQTDQ
2041: LRRYTEIKQS DLPSAVAAKK TREYRCPPRE QMNAILSFKH LEESEEKDNC PCGEELIARM
2101: NDFHESLMAH VSLHALQEPD GSENQEPEAK PGAFGQLYNI INTVKDMEEE AKAIEEPIRK
2161: TPEEKFRKVL IQTIVSWAEE SQIETPKLVR EMFSLLVRQY DAVGELIRAL EKTYVINAKT
2221: KLDVAEMWVG LSQIRALLPV QMSQEEEELM RKRLWKLVNN HTFFQHPDLI RVLRVHENVM
2281: AVMMNTLGRR AQAQSDAQPA SPPVTEDKQE KDTSHEMVVA CCRFLCYFCR TGRQNQKAMF
2341: DHFDFLLENS NILLSRPSLR GSTPLDVAYS SLMENTELAL ALREHYLEKI AVYLSRCGLQ
2401: SNSELIEKGY PDLGWDPVEG ERYLDFLRFC VWVNGESVEE NANLVIRLLI RRPECLGPAL
2461: RGEGEGLLKA IVDANKMSER IADRRKLREI EQEGDVTFTH PLPESDEDED YIDTGAAILN
2521: FYCTLVDLLG RCAPDAGVIA LGKNESLRAR AILRSLVPLE DLQGVLSLRF TLNNPAAGEE
2581: RPKSDMPSDL IPGHKQSVGL FLERVYGIET QELFYKLLEE AFLPDLRAAT MLDRNDGCES
2641: DMALSMNRYI GNSILPLLIK HAYFYNEAEN YASLLDATLH TVYRLSKNRM LTKGQREAVS
2701: DFLVALTSAM QPSMLLKLLR KLTVDVSKLS EYTTVALRLL TLHYERCAKY YGSTGAGQGV
2761: FGASSDEEKC LTMMLFSNIF DSLSKMDYEP ELLGKALPCL IAIGCALPPD YSLSKNYDDE
2821: FYGKEQVTGG LDNPQYDPQP INTSSVALNN DLNTIVQKFS EHYHDAWASR KIENGWVYAE
2881: SWSDSQKSHP RLKPYNMLND YEKERYKEPV RESLKALLAI GWSVEHSEVD IPSTNRSSMR
2941: RQSKSGGRPP DIVTDSATPF NYNPHPVDMT NLTLSREMQN MAERLADNAH DIWAKKKKEE
3001: LVTNGGGIHP QLVPYDLLTD KEKKKDRERS QEFLKYLQYQ GYKLHRPSKA PQSDTEQTTT
3061: GVAIELRFAY SLLEKLIQYI DRATINMKLL KPSTTFSRRS SFKTSTRDIK FFSKVVLPLM
3121: EKYFSTHRNY FIAVATATNN IGAASLKEKE MVAALFCKLA SLLRSRLAAF RPDVRITVRC
3181: LQVLVKGIDA KSLVKNCPEF IRTSMLTFFN NVADDVGHTI NNLQEGKYAH LRGTHLKTST
3241: SLGYINGVLL PILTAKFDHL ANCEYGSDLL LDEIQVASYK MLGSLYALGT DATLTHDRKY
3301: LKTEIERHKP ALGSCLGAFS STFPVAFLEP HLNKHNQFSL LNRIADHSLE AQDIMQKMEQ
3361: CMPTLETILG EVDQFVESDK TYNEAPHIID VVLPLLCSYL PFWWAQGPDN VTPTGGNHVT
3421: MVTAEHMNQL LKNVLKLIKK NIGNENAPWM TRIATYTQQI IINSSEELLR DSFLPLAERV
3481: RKRTDNMFHK EESLRGFIKS STDDTSQVES QIQEDWQLLV RDIYSFYPLL IKYVDLQRNH
3541: WLRNNVPEAE ELYNHVAEIF NIWSKSQYFL KEEQNFISAN EIDNMVLIMP TATRRLTAVT
3601: DGTPQAGGKK KKKHRDKKRD KDKEVQASLM VACLKRLLPV GLNLFAGREQ ELVQHCKDRF
3661: LKVGTLKKMS EQDVAEFAKT QLTLPDKIDP ADEMSWQHYL YSKLGSKSKS NITVETAENK
3721: AKIIDDTVER IVAMSKVLFG LHMIDHPQQM SKNVYRSVVS IQRKRAVIAC FRQTSLHSLP
3781: RHRACNIFAR TYYELWLEEE NKGQEVMIED LTQSFEDAEL KKSDVVEEGE KPDPLTQLVT
3841: TFCRGAMTER SGALQEDPLY MSYAHIIAKS CGEEEEEGGG EEEEGGGGEP EAEEEGRASI
3901: HEQEMEKQKL LFHQARLADR GVAEMVLLHI SASKGLPSEM VMKTLQLGIS ILRGGNIDIQ
3961: MGMLNHLKDK KDVGFFTSIA GLMNSCSVLD LDAFERDTKA EGLGVGLEGA AGEKNMHDAE
4021: FTCALFRFIQ LTCEGHNLDW QNYLRTQAGN TTTVNVVICT VDYLLRLQES IMDFYWHYSS
4081: KELIDPAGKA NFFKAIGVAS QVFNTLTEVI QGPCTQNQQA LAHSRLWDAV GGFLFLFSHM
4141: QDKLSKHSSQ VDLLKELLNL QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESASNVELIL
4201: KYFDMFLKLK DLTSSASFQE IDANSDGWVL PKDFKEKMEQ QKSYAPEEIE FLLACCETNH
4261: DGKLDYVGFC DRFHEPAKEI GFNLAVLLTN LSEHMPNEPR LARFLETAGS VLNYFEPFLG
4321: RIEIMGGSKR IERVYFEIKE SDIEQWEKPQ IKESKRAFFY SIVTEGGDKE KLEAFVNFCE
4381: DAIFEMTHAS GLMAASEESV GGTKNREASY MYMGDDDDER AGKDPFRRGL QSVKDGFATA
4441: FSSLSPSNIK QKIADMQQMP PAELAVGFFK MFFYLFYYLG YGVLVVVRYI LGVLLGLMRG
4501: PQTDEPPPEP TEEEKIGQLR HRLLATQSSR HLPALPAADD TGQLQVSAFG LDITKEDNGQ
4561: IQVKPHESPS TSTPSSGEEA EVSPDEGTEH SEEQRPPSLI DLLGGEQAKK QAQERMEAQA
4621: AQQAAMSAIE AESKKAVQVP APSALSQVDL SQYTRRAVSF LARNFYNLKY VALVLAFCIN
4681: FVLLFYKVST LDVEGGEGSG IGDIIAAAAG SGSGSGSGSG DGGSGESDDA DDVIEVVHID
4741: EDFFYMEHVI KVAAAMHSVV SLAILIGYYH LKVPLAIFKR EKEIARKLEF DGLYIAEQPE
4801: DDDLKSHWDK LVISAKSFPV NYWDKFVKKK VRAKYSETYD FDSISNMLGM EKTSFTAQED
4861: EGSKGLINYI INIDWRYQVW KAGVTITDNS FLYSLWYFSF SVMGNFNNFF FAAHLLDVAV
4921: GFKTLRTILQ SVTHNGKQLV LTVMLLTIIV YIYTVIAFNF FRKFYVQEED DEVNRNCHDM
4981: LTCFVFNLYK GVRAGGGIGD ELEPPDGDDS EVYRIIFDIT FFFFIIVILL AILQGLIIDA
5041: FGRLRDQLES VKEDMESNCF ICGINKDYFD KVPHGFDTHV QREHNLANYM FFLMHLINKP
5101: DTEYTGQETY VWNMYTQRCW DFFPVGDCFR KQYEDLMGE