1.A.3.1.11 The ryanodine receptor of 5140 aas and 6 C-terminal TMSs. It is the targets of diamide insecticides. The mutation I4743M contributes to diamide insecticide resistance (Zuo et al. 2020). The diamide binding site on the Lepidopteran Ryanodine Receptor has been examined (Richardson et al. 2021).
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Accession Number: | AIA23854.1 |
Protein Name: | AIA23854.1 ryanodine receptor [Spodoptera exigua] |
Length: | 5136 |
Molecular Weight: | |
Species: | Spodoptera exigua [7107] |
Number of TMSs: | 6 |
Substrate |
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1: MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN IADKNIPPDL
61: SQCVFVIEQA LSVRALQELV TAAGSETGKE NLGKGTGSGH RTLLYGNAIL LRHLNSDMYL
121: ACLSTSSSQD KLAFDVGLQE HSQGEACWWT LHPASKQRSE GEKVRVGDDL ILVSVATERY
181: LHTTKENEVS IVNASFHVTH WSVQPYGTGI SRMKYVGYVF GGDVLRFFHG GDECLTIPST
241: WTKDGGQNIV VYEGGSVMSQ ARSLWRLELA RTKWAGGFIN WYHPMRIRHI TTGRYLGVND
301: QNELYLVSRE EATTASCAFC LRQEKDDQKQ VLEDKDLEVI GAPIIKYGDS TVIVQHSETG
361: LWLSYKSYET KKKGVGKVEE KQAILHEEGK MDDGLDFSRS QEEESRTARV IRECSSLFTK
421: FINGLETLQE NRRHSMFFAS VNLGEMVMCL EDLINYFAQP DEDMEHEEKQ NKFRALRNRQ
481: DLFQEEGILN LILEAIDKIN VITSQGFLAG FLAGDESGQS WEMISGYLYQ LPAAIIKGNH
541: TNCAQFANSN RLNWLFSRLG SQASGEGTGM LDVLHCVLID SPEALNMMRD EHIKVIISLL
601: EKHGRDPKVL DVLCSLCVGN GVAVRSSQNN ICDYLLPGKN LLLQTALVDH VSSVRPNIFV
661: GRVEGSAVYR KWYFEVTMDH IEKTTHMMPH LRIGWTNTTG YVPYPGGGEK WGGNGVGDDL
721: YSYGFDGAYP WSGGRKTQVN RTHAEEPYIR KGDVIGCALD LTVPIINFMF NGVRVTGSFT
781: NFNLEGMFFP VISCSSKLSC RFLLGGEHGR LRYAAPEGYS PLVESLLPQQ ILSLEPCFYF
841: GNLAKRALAG PPLVQDDTAF VPTPVDTLQI PLPSYVEQIR DKLAENIHEM WAMNKIEAGW
901: MYGDQRDDLH KIHPCLAPFE RLPPAEKRYD IQLAVQTLKT ILALGYYISL DKPPARIRNV
961: RLPNEPFMQS NGYKPAPLDL SAVTLTPKMD ELVDQLAENT HNLWARERIQ QGWTYGLNED
1021: PDMHRSPHLV PYPKVDDAIK KANRDTASET VRTLLAYGYN LDPPTGEQHE ALLLEASKQK
1081: QAEFRTYRAE KNYAVGSGKW YFEFEILTAG PMRVGWAHAD MAPGMMLGQD ENSWAFDGYN
1141: EEKVYSGSTE SFGKQWSVGD VVGVFLDLID KTISFSLNGE LLMDALGGET TFADVQGDNF
1201: VPACTLGVGQ KARLTYGQDV NILKYFTTCG LQEGYEPFCV NMKRDVTHWY TKDQPIFEDT
1261: DEMIDTKIDV TRIPAGSDTP PCLEISHNTF ETMEKANWEF LRLSLPVICH NEFIDEAEKA
1321: RRWVEIKERQ QILMKEAVEA QMPAHIDQIM RSGFTMNDIK GLHYEDNQEE VPSSKVKRQP
1381: SRPPRKGSMT RGVSIQNYNN LQPGQVNGMH RSTSEAEMAK YELGAQNLSP DDKKDKRGRS
1441: PFKFFRSKRG ESSDRAKSRK SKTPDPFSDT EVSPERGPRR PNPQIKVSQA NQRYNGMNAR
1501: PSRTNLYGSQ VGLNSNAQMA TPTQDRKQMT TSTLAQSTTE TVGNEIFDGE CLKLINEYFY
1561: GVRIFPGQDP THVYIGWVTT QYHLHSKDFN QSKVTKSSVI ITDDYDRIVE NVNRQSCYMV
1621: RADELYDEVM AEATAKGASQ GMFIGCSVDT STGTVSFTCE GKDTSFKFKM EPETKLFPAI
1681: FVEATSKEIL QIELGRSTTS LPLSAAVLPT SDKHVIPQFP PRLKVQCLKP HQWARVPNQS
1741: LQVHALKLSD IRGWSMLCED AVSMLALHIP EEDRCIDILE LIEMDKLLSF HSHTLTLYAA
1801: LCYQSNYRAA HALCTHVDQK QLLYAIQSQY MSGPLRQGFY DLLIALHLES HATTMEACKN
1861: EFVIPLGPEL KSLYEDPEMG HSLRSLQTES VRPQMKMTDI AESITDISNL YSPYFPLEVV
1921: REFVMQALAE AVETNQVHNR DPVGGSNENL FLPLIKLVDR LLLVGVMRDE DVEKLLIMTN
1981: PETWDPSFDK EGKDEHRKGL LHMKMAEGAK LQMCYLLQRL NDIQLRHRVE AITAFAHDFV
2041: GDLQTDQLRR YTEIKQSDLP SAVAAKKTRE FRCPPREQMN AILSFKHLEE EDKENCPCGE
2101: ELIARMNEFH ESLMAHVSLH ALQEPDGTEN QEPEAKPGAF GKLYNIINTV KELEEEPKAI
2161: DEPPKKTPEE KFRKVLIQTI VNWAEESQIE TPKLVREMFS LLVRQYDAVG ELIRALEKTY
2221: VINAKTKLDV AEMWVGLSQI RALLPVQMSQ EEEELMRKRL WKLVNNHTFF QHPDLIRVLR
2281: VHENVMAVMM NTLGRRAQAQ SDAQPASPPV AEDSKEKDTS HEMVVACCRF LCYFCRTGRQ
2341: NQKAMFDHFD FLLENSNNLL SRPSLRESTP LDVAYSSLME NTELALALRE HYLEKIAVYL
2401: SRRGLQSNSE LVEKGYPDLG WDPVEGERYL DFLRFCVWVN GESVEENANL VIRLLIRRPE
2461: YLGPALRGEG EGLLKAIVDA NKMSERIADR RKLREMEQEG DVSFSHPLPE SDDDEDYIDT
2521: GAAILNFYCT LVDLLGRCAP DAGVIALGKN ESLRARAILR SLVPLEDLQG VLSLRFTLNN
2581: PAAGGERPKS DMPSGLIPGH KQSVGLFLER VYGIETQELF YKLLEEAFLP DLRAATMLDR
2641: NDGCESDMAL SMNRYIGNSI LPLLIKHAYF YNEAENYASL LDATLHTVYR LSKNRMLTKG
2701: QREAVSGFLV ALTSAMQPSM LLKLLRKLTV DVSKLSEYTT VALRLLTLHY ERCAKYYGST
2761: GAGQGVYGAS SDEEKRLTMM LFSNIFDSLS KMDYEPELFG KALPCLIAIG CALPPDYSLS
2821: KNYDDEFYGK EQVAGDLDNP QYDPQPINTS SVALNNDLNT IVQKFSEHYH DAWASRKIGN
2881: GWVYGEGWSD SQKTHPRLKP YNMLNDYEKE RYKEPVRESL KALLAIGWSV EHSEVDIPST
2941: NRSSMRRQSK SGGRPPDLVT DSATPFNYNP HSVDMTNLTL SREMQNMAER LADNAHDIWA
3001: KKKKEELVTN GGGIHPQLVP YDLLTDKEKK RDRERSQEFL KYLQYQGYKL HRPSKAPQSD
3061: TEQTTTGVAI EPRFAYSLLE KLIQYIDRAA INMKLLKPST TFSRRTSFKT STRDIKFFSK
3121: VVLPLMEKYF STHRNYFIAV ATATNNVGAA SLEEKEMVAA LFCKLASLLR SRLAAFGPDV
3181: RITVRCLQVL VKGIDAKSLV KNCPEFIRTS MLTFFNNVAD DVGHTIMNLQ DGKYAHLRGT
3241: HLKTSTSLGY INGVLLPILT AKFDHLANCE YGADLLLDEI QVASYKMLGS LYALGTDASL
3301: THDRKYLKTE IERHKPALGS CLGAFSSTFP VAFLEPHLNK HNQFSLLNRI ADHSLEAQDI
3361: MQKMEQCMPT LETILGEVDQ FVESDKTYNE APHIIDVVLP LLCSYLPFWW AQGPDNVTPT
3421: GGNHVTMVTA EHMNQLLKNV LKLIKKNIGN ENAPWMTRIA THTQQIIINS SEELLRDSFP
3481: PLAERVRKRT DNMFHKEESL RGFIKSSTDD TSQVESQIQE DWQLLVRDIY SFYPLPIKYV
3541: DLQRNHWLRN NVPEAEELYN HVAEIFNIWS KSQYFLKEEQ NFISANEIDN MVLIMPTATR
3601: RVTAVVDGTP QAGGKKKKKH RDKKRDKDKE VQASLMVACL KRLLPVGLNL FAGREQELVQ
3661: HCKDRFLKKM SEQDVAEFAK TQLTLPDKID PADEMSWQHY LYSKLGSKSK TNITVETAEN
3721: KAKIIDDTVE RIVAMSKVLF GLHMIDHPQQ MSKNVYRSVV SIQRKRAVIA CFKQTSLHSL
3781: PRHRACNIFA RTYYELWLEE ENVGQEVMIE DLTQSFEDAE LKKSDGEEEG EKPDPLTQLV
3841: TTFCRGAMTE RSGALQEDPL YMSYAHIIAK SCGEEEEEGG GEEEEGGGEA EAEDEGRASI
3901: HEQEMEKQKL LFHQARLANR GVAEMVLLHI SASKGLPSEM VMKTLQLGIS ILRGGNIDIQ
3961: MGMLNHLKDK KDVGFFTSIA GLMNSCSVLD LDAFERNTKA EGLGVGLEGV AGEKNMHDAE
4021: FTCALFRFIQ LTCEGHNLDW QNYLRTQAGN TTTVNVVICT VGYLLRLQES IVDFYWHYSS
4081: KELIDPAGKA NFFKAISVAS QVFNTLTEVI QGPCTQNQQA LAHSRLWDAV GGFLFLFSHM
4141: QDKLSRHSSQ VNLLKELLSL QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESASNVELIL
4201: KYFDMFLKLK DLTSSASFQE IDANNDGWVL PKDFKEKMEQ QKSYTPEEIE FLLACCETNH
4261: DGKLNYIGFC DRFHEPAKEI GFNLAVLLTN LSEHMPNEPR LARFLETAGS VLNYFEPFLG
4321: RIEIMGGSKR IERVYFEIKE SNIEQWEKPQ IKESKRAFFY SIVTEGGDKE KLEAFVNFCE
4381: DAIFEMTHAS GLMAASEESV GGTKNREASY MYMGDDDDER AGKDPFRRGL QSVKDGIYAA
4441: FSSLSPSNMK AKIADLQQMP PAELAVGFFK MFFLLFYYLG YGMLVVIRYI FGVLLGLMRG
4501: PQTDEPPPEP TEEEKIGQLR HRLLATQSSR HLPALPPADD TGQIQVSAFG LDITKEDNEQ
4561: IQVKPHESPS TSTPSPGEEA EVSPDESADH PEEQRPPSLI DLLGGEQAKK QAQERMEAQA
4621: AKQAAMSAIE AESKKAVQVP APSALSQVDP SQYTRRAVSF LARNFYNLKY VALVLAFCIN
4681: FVLLFYKVST LDAEGGEGSG LGDIIAGSGS GSGSGSGDGG SGESEDDDAL EVVHIDEDFF
4741: YMEHVIKVAA VLHSIVSLAI LIGYYHLKVP LAIFKREKEI ARKLEFDGLY IAEQPENDDL
4801: KSHWDKLVIS AKSFPVNYWD KFVRKKVRAK YSETYDFDSI SNMLGMEKTS FSAQEEEGSK
4861: GLIHYIINID WRYQVWKAGV TITDNSFLYS LWYFSFSVMG NFNNFFFAAH LLDVAVGFKT
4921: LGTILQSVTH NGKQLVLTVM LLTIIVYIYT VIAFNFFRKF YVQEEDDEVN RNCHDMLTCF
4981: VFNLYKGVRA GGGIGDELEP PDGDDSEVYR IIFDITFFFF IIVILLAILQ GLIIDAFGEL
5041: RDQLESVKED MESNCFICGI NKDYFDKVPH GFDTHVQREH NLANYMFFLM HLINKPDTEY
5101: TGQETYVWNM YTQRCWDFFP VGDCFRKQYE DLMGE