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1.A.3.1.11
The ryanodine receptor of 5135 aas and 6 C-terminal TMSs. It is the targets of diamide insecticides. The mutation I4743M contributes to diamide insecticide resistance (Zuo et al. 2020).

Accession Number:AIA23854.1
Protein Name:AIA23854.1 ryanodine receptor [Spodoptera exigua]
Length:5136
Molecular Weight:
Species:Spodoptera exigua [7107]
Number of TMSs:6
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN IADKNIPPDL 
61:	SQCVFVIEQA LSVRALQELV TAAGSETGKE NLGKGTGSGH RTLLYGNAIL LRHLNSDMYL 
121:	ACLSTSSSQD KLAFDVGLQE HSQGEACWWT LHPASKQRSE GEKVRVGDDL ILVSVATERY 
181:	LHTTKENEVS IVNASFHVTH WSVQPYGTGI SRMKYVGYVF GGDVLRFFHG GDECLTIPST 
241:	WTKDGGQNIV VYEGGSVMSQ ARSLWRLELA RTKWAGGFIN WYHPMRIRHI TTGRYLGVND 
301:	QNELYLVSRE EATTASCAFC LRQEKDDQKQ VLEDKDLEVI GAPIIKYGDS TVIVQHSETG 
361:	LWLSYKSYET KKKGVGKVEE KQAILHEEGK MDDGLDFSRS QEEESRTARV IRECSSLFTK 
421:	FINGLETLQE NRRHSMFFAS VNLGEMVMCL EDLINYFAQP DEDMEHEEKQ NKFRALRNRQ 
481:	DLFQEEGILN LILEAIDKIN VITSQGFLAG FLAGDESGQS WEMISGYLYQ LPAAIIKGNH 
541:	TNCAQFANSN RLNWLFSRLG SQASGEGTGM LDVLHCVLID SPEALNMMRD EHIKVIISLL 
601:	EKHGRDPKVL DVLCSLCVGN GVAVRSSQNN ICDYLLPGKN LLLQTALVDH VSSVRPNIFV 
661:	GRVEGSAVYR KWYFEVTMDH IEKTTHMMPH LRIGWTNTTG YVPYPGGGEK WGGNGVGDDL 
721:	YSYGFDGAYP WSGGRKTQVN RTHAEEPYIR KGDVIGCALD LTVPIINFMF NGVRVTGSFT 
781:	NFNLEGMFFP VISCSSKLSC RFLLGGEHGR LRYAAPEGYS PLVESLLPQQ ILSLEPCFYF 
841:	GNLAKRALAG PPLVQDDTAF VPTPVDTLQI PLPSYVEQIR DKLAENIHEM WAMNKIEAGW 
901:	MYGDQRDDLH KIHPCLAPFE RLPPAEKRYD IQLAVQTLKT ILALGYYISL DKPPARIRNV 
961:	RLPNEPFMQS NGYKPAPLDL SAVTLTPKMD ELVDQLAENT HNLWARERIQ QGWTYGLNED 
1021:	PDMHRSPHLV PYPKVDDAIK KANRDTASET VRTLLAYGYN LDPPTGEQHE ALLLEASKQK 
1081:	QAEFRTYRAE KNYAVGSGKW YFEFEILTAG PMRVGWAHAD MAPGMMLGQD ENSWAFDGYN 
1141:	EEKVYSGSTE SFGKQWSVGD VVGVFLDLID KTISFSLNGE LLMDALGGET TFADVQGDNF 
1201:	VPACTLGVGQ KARLTYGQDV NILKYFTTCG LQEGYEPFCV NMKRDVTHWY TKDQPIFEDT 
1261:	DEMIDTKIDV TRIPAGSDTP PCLEISHNTF ETMEKANWEF LRLSLPVICH NEFIDEAEKA 
1321:	RRWVEIKERQ QILMKEAVEA QMPAHIDQIM RSGFTMNDIK GLHYEDNQEE VPSSKVKRQP 
1381:	SRPPRKGSMT RGVSIQNYNN LQPGQVNGMH RSTSEAEMAK YELGAQNLSP DDKKDKRGRS 
1441:	PFKFFRSKRG ESSDRAKSRK SKTPDPFSDT EVSPERGPRR PNPQIKVSQA NQRYNGMNAR 
1501:	PSRTNLYGSQ VGLNSNAQMA TPTQDRKQMT TSTLAQSTTE TVGNEIFDGE CLKLINEYFY 
1561:	GVRIFPGQDP THVYIGWVTT QYHLHSKDFN QSKVTKSSVI ITDDYDRIVE NVNRQSCYMV 
1621:	RADELYDEVM AEATAKGASQ GMFIGCSVDT STGTVSFTCE GKDTSFKFKM EPETKLFPAI 
1681:	FVEATSKEIL QIELGRSTTS LPLSAAVLPT SDKHVIPQFP PRLKVQCLKP HQWARVPNQS 
1741:	LQVHALKLSD IRGWSMLCED AVSMLALHIP EEDRCIDILE LIEMDKLLSF HSHTLTLYAA 
1801:	LCYQSNYRAA HALCTHVDQK QLLYAIQSQY MSGPLRQGFY DLLIALHLES HATTMEACKN 
1861:	EFVIPLGPEL KSLYEDPEMG HSLRSLQTES VRPQMKMTDI AESITDISNL YSPYFPLEVV 
1921:	REFVMQALAE AVETNQVHNR DPVGGSNENL FLPLIKLVDR LLLVGVMRDE DVEKLLIMTN 
1981:	PETWDPSFDK EGKDEHRKGL LHMKMAEGAK LQMCYLLQRL NDIQLRHRVE AITAFAHDFV 
2041:	GDLQTDQLRR YTEIKQSDLP SAVAAKKTRE FRCPPREQMN AILSFKHLEE EDKENCPCGE 
2101:	ELIARMNEFH ESLMAHVSLH ALQEPDGTEN QEPEAKPGAF GKLYNIINTV KELEEEPKAI 
2161:	DEPPKKTPEE KFRKVLIQTI VNWAEESQIE TPKLVREMFS LLVRQYDAVG ELIRALEKTY 
2221:	VINAKTKLDV AEMWVGLSQI RALLPVQMSQ EEEELMRKRL WKLVNNHTFF QHPDLIRVLR 
2281:	VHENVMAVMM NTLGRRAQAQ SDAQPASPPV AEDSKEKDTS HEMVVACCRF LCYFCRTGRQ 
2341:	NQKAMFDHFD FLLENSNNLL SRPSLRESTP LDVAYSSLME NTELALALRE HYLEKIAVYL 
2401:	SRRGLQSNSE LVEKGYPDLG WDPVEGERYL DFLRFCVWVN GESVEENANL VIRLLIRRPE 
2461:	YLGPALRGEG EGLLKAIVDA NKMSERIADR RKLREMEQEG DVSFSHPLPE SDDDEDYIDT 
2521:	GAAILNFYCT LVDLLGRCAP DAGVIALGKN ESLRARAILR SLVPLEDLQG VLSLRFTLNN 
2581:	PAAGGERPKS DMPSGLIPGH KQSVGLFLER VYGIETQELF YKLLEEAFLP DLRAATMLDR 
2641:	NDGCESDMAL SMNRYIGNSI LPLLIKHAYF YNEAENYASL LDATLHTVYR LSKNRMLTKG 
2701:	QREAVSGFLV ALTSAMQPSM LLKLLRKLTV DVSKLSEYTT VALRLLTLHY ERCAKYYGST 
2761:	GAGQGVYGAS SDEEKRLTMM LFSNIFDSLS KMDYEPELFG KALPCLIAIG CALPPDYSLS 
2821:	KNYDDEFYGK EQVAGDLDNP QYDPQPINTS SVALNNDLNT IVQKFSEHYH DAWASRKIGN 
2881:	GWVYGEGWSD SQKTHPRLKP YNMLNDYEKE RYKEPVRESL KALLAIGWSV EHSEVDIPST 
2941:	NRSSMRRQSK SGGRPPDLVT DSATPFNYNP HSVDMTNLTL SREMQNMAER LADNAHDIWA 
3001:	KKKKEELVTN GGGIHPQLVP YDLLTDKEKK RDRERSQEFL KYLQYQGYKL HRPSKAPQSD 
3061:	TEQTTTGVAI EPRFAYSLLE KLIQYIDRAA INMKLLKPST TFSRRTSFKT STRDIKFFSK 
3121:	VVLPLMEKYF STHRNYFIAV ATATNNVGAA SLEEKEMVAA LFCKLASLLR SRLAAFGPDV 
3181:	RITVRCLQVL VKGIDAKSLV KNCPEFIRTS MLTFFNNVAD DVGHTIMNLQ DGKYAHLRGT 
3241:	HLKTSTSLGY INGVLLPILT AKFDHLANCE YGADLLLDEI QVASYKMLGS LYALGTDASL 
3301:	THDRKYLKTE IERHKPALGS CLGAFSSTFP VAFLEPHLNK HNQFSLLNRI ADHSLEAQDI 
3361:	MQKMEQCMPT LETILGEVDQ FVESDKTYNE APHIIDVVLP LLCSYLPFWW AQGPDNVTPT 
3421:	GGNHVTMVTA EHMNQLLKNV LKLIKKNIGN ENAPWMTRIA THTQQIIINS SEELLRDSFP 
3481:	PLAERVRKRT DNMFHKEESL RGFIKSSTDD TSQVESQIQE DWQLLVRDIY SFYPLPIKYV 
3541:	DLQRNHWLRN NVPEAEELYN HVAEIFNIWS KSQYFLKEEQ NFISANEIDN MVLIMPTATR 
3601:	RVTAVVDGTP QAGGKKKKKH RDKKRDKDKE VQASLMVACL KRLLPVGLNL FAGREQELVQ 
3661:	HCKDRFLKKM SEQDVAEFAK TQLTLPDKID PADEMSWQHY LYSKLGSKSK TNITVETAEN 
3721:	KAKIIDDTVE RIVAMSKVLF GLHMIDHPQQ MSKNVYRSVV SIQRKRAVIA CFKQTSLHSL 
3781:	PRHRACNIFA RTYYELWLEE ENVGQEVMIE DLTQSFEDAE LKKSDGEEEG EKPDPLTQLV 
3841:	TTFCRGAMTE RSGALQEDPL YMSYAHIIAK SCGEEEEEGG GEEEEGGGEA EAEDEGRASI 
3901:	HEQEMEKQKL LFHQARLANR GVAEMVLLHI SASKGLPSEM VMKTLQLGIS ILRGGNIDIQ 
3961:	MGMLNHLKDK KDVGFFTSIA GLMNSCSVLD LDAFERNTKA EGLGVGLEGV AGEKNMHDAE 
4021:	FTCALFRFIQ LTCEGHNLDW QNYLRTQAGN TTTVNVVICT VGYLLRLQES IVDFYWHYSS 
4081:	KELIDPAGKA NFFKAISVAS QVFNTLTEVI QGPCTQNQQA LAHSRLWDAV GGFLFLFSHM 
4141:	QDKLSRHSSQ VNLLKELLSL QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESASNVELIL 
4201:	KYFDMFLKLK DLTSSASFQE IDANNDGWVL PKDFKEKMEQ QKSYTPEEIE FLLACCETNH 
4261:	DGKLNYIGFC DRFHEPAKEI GFNLAVLLTN LSEHMPNEPR LARFLETAGS VLNYFEPFLG 
4321:	RIEIMGGSKR IERVYFEIKE SNIEQWEKPQ IKESKRAFFY SIVTEGGDKE KLEAFVNFCE 
4381:	DAIFEMTHAS GLMAASEESV GGTKNREASY MYMGDDDDER AGKDPFRRGL QSVKDGIYAA 
4441:	FSSLSPSNMK AKIADLQQMP PAELAVGFFK MFFLLFYYLG YGMLVVIRYI FGVLLGLMRG 
4501:	PQTDEPPPEP TEEEKIGQLR HRLLATQSSR HLPALPPADD TGQIQVSAFG LDITKEDNEQ 
4561:	IQVKPHESPS TSTPSPGEEA EVSPDESADH PEEQRPPSLI DLLGGEQAKK QAQERMEAQA 
4621:	AKQAAMSAIE AESKKAVQVP APSALSQVDP SQYTRRAVSF LARNFYNLKY VALVLAFCIN 
4681:	FVLLFYKVST LDAEGGEGSG LGDIIAGSGS GSGSGSGDGG SGESEDDDAL EVVHIDEDFF 
4741:	YMEHVIKVAA VLHSIVSLAI LIGYYHLKVP LAIFKREKEI ARKLEFDGLY IAEQPENDDL 
4801:	KSHWDKLVIS AKSFPVNYWD KFVRKKVRAK YSETYDFDSI SNMLGMEKTS FSAQEEEGSK 
4861:	GLIHYIINID WRYQVWKAGV TITDNSFLYS LWYFSFSVMG NFNNFFFAAH LLDVAVGFKT 
4921:	LGTILQSVTH NGKQLVLTVM LLTIIVYIYT VIAFNFFRKF YVQEEDDEVN RNCHDMLTCF 
4981:	VFNLYKGVRA GGGIGDELEP PDGDDSEVYR IIFDITFFFF IIVILLAILQ GLIIDAFGEL 
5041:	RDQLESVKED MESNCFICGI NKDYFDKVPH GFDTHVQREH NLANYMFFLM HLINKPDTEY 
5101:	TGQETYVWNM YTQRCWDFFP VGDCFRKQYE DLMGE