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1.A.3.1.11
The ryanodine receptor of 5140 aas and 6 C-terminal TMSs. It is the targets of diamide insecticides. The mutation I4743M contributes to diamide insecticide resistance (Zuo et al. 2020). The diamide binding site on the Lepidopteran Ryanodine Receptor has been examined (Richardson et al. 2021).

Accession Number:AIA23854.1
Protein Name:AIA23854.1 ryanodine receptor [Spodoptera exigua]
Length:5136
Molecular Weight:
Species:Spodoptera exigua [7107]
Number of TMSs:6
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN IADKNIPPDL 
61:	SQCVFVIEQA LSVRALQELV TAAGSETGKE NLGKGTGSGH RTLLYGNAIL LRHLNSDMYL 
121:	ACLSTSSSQD KLAFDVGLQE HSQGEACWWT LHPASKQRSE GEKVRVGDDL ILVSVATERY 
181:	LHTTKENEVS IVNASFHVTH WSVQPYGTGI SRMKYVGYVF GGDVLRFFHG GDECLTIPST 
241:	WTKDGGQNIV VYEGGSVMSQ ARSLWRLELA RTKWAGGFIN WYHPMRIRHI TTGRYLGVND 
301:	QNELYLVSRE EATTASCAFC LRQEKDDQKQ VLEDKDLEVI GAPIIKYGDS TVIVQHSETG 
361:	LWLSYKSYET KKKGVGKVEE KQAILHEEGK MDDGLDFSRS QEEESRTARV IRECSSLFTK 
421:	FINGLETLQE NRRHSMFFAS VNLGEMVMCL EDLINYFAQP DEDMEHEEKQ NKFRALRNRQ 
481:	DLFQEEGILN LILEAIDKIN VITSQGFLAG FLAGDESGQS WEMISGYLYQ LPAAIIKGNH 
541:	TNCAQFANSN RLNWLFSRLG SQASGEGTGM LDVLHCVLID SPEALNMMRD EHIKVIISLL 
601:	EKHGRDPKVL DVLCSLCVGN GVAVRSSQNN ICDYLLPGKN LLLQTALVDH VSSVRPNIFV 
661:	GRVEGSAVYR KWYFEVTMDH IEKTTHMMPH LRIGWTNTTG YVPYPGGGEK WGGNGVGDDL 
721:	YSYGFDGAYP WSGGRKTQVN RTHAEEPYIR KGDVIGCALD LTVPIINFMF NGVRVTGSFT 
781:	NFNLEGMFFP VISCSSKLSC RFLLGGEHGR LRYAAPEGYS PLVESLLPQQ ILSLEPCFYF 
841:	GNLAKRALAG PPLVQDDTAF VPTPVDTLQI PLPSYVEQIR DKLAENIHEM WAMNKIEAGW 
901:	MYGDQRDDLH KIHPCLAPFE RLPPAEKRYD IQLAVQTLKT ILALGYYISL DKPPARIRNV 
961:	RLPNEPFMQS NGYKPAPLDL SAVTLTPKMD ELVDQLAENT HNLWARERIQ QGWTYGLNED 
1021:	PDMHRSPHLV PYPKVDDAIK KANRDTASET VRTLLAYGYN LDPPTGEQHE ALLLEASKQK 
1081:	QAEFRTYRAE KNYAVGSGKW YFEFEILTAG PMRVGWAHAD MAPGMMLGQD ENSWAFDGYN 
1141:	EEKVYSGSTE SFGKQWSVGD VVGVFLDLID KTISFSLNGE LLMDALGGET TFADVQGDNF 
1201:	VPACTLGVGQ KARLTYGQDV NILKYFTTCG LQEGYEPFCV NMKRDVTHWY TKDQPIFEDT 
1261:	DEMIDTKIDV TRIPAGSDTP PCLEISHNTF ETMEKANWEF LRLSLPVICH NEFIDEAEKA 
1321:	RRWVEIKERQ QILMKEAVEA QMPAHIDQIM RSGFTMNDIK GLHYEDNQEE VPSSKVKRQP 
1381:	SRPPRKGSMT RGVSIQNYNN LQPGQVNGMH RSTSEAEMAK YELGAQNLSP DDKKDKRGRS 
1441:	PFKFFRSKRG ESSDRAKSRK SKTPDPFSDT EVSPERGPRR PNPQIKVSQA NQRYNGMNAR 
1501:	PSRTNLYGSQ VGLNSNAQMA TPTQDRKQMT TSTLAQSTTE TVGNEIFDGE CLKLINEYFY 
1561:	GVRIFPGQDP THVYIGWVTT QYHLHSKDFN QSKVTKSSVI ITDDYDRIVE NVNRQSCYMV 
1621:	RADELYDEVM AEATAKGASQ GMFIGCSVDT STGTVSFTCE GKDTSFKFKM EPETKLFPAI 
1681:	FVEATSKEIL QIELGRSTTS LPLSAAVLPT SDKHVIPQFP PRLKVQCLKP HQWARVPNQS 
1741:	LQVHALKLSD IRGWSMLCED AVSMLALHIP EEDRCIDILE LIEMDKLLSF HSHTLTLYAA 
1801:	LCYQSNYRAA HALCTHVDQK QLLYAIQSQY MSGPLRQGFY DLLIALHLES HATTMEACKN 
1861:	EFVIPLGPEL KSLYEDPEMG HSLRSLQTES VRPQMKMTDI AESITDISNL YSPYFPLEVV 
1921:	REFVMQALAE AVETNQVHNR DPVGGSNENL FLPLIKLVDR LLLVGVMRDE DVEKLLIMTN 
1981:	PETWDPSFDK EGKDEHRKGL LHMKMAEGAK LQMCYLLQRL NDIQLRHRVE AITAFAHDFV 
2041:	GDLQTDQLRR YTEIKQSDLP SAVAAKKTRE FRCPPREQMN AILSFKHLEE EDKENCPCGE 
2101:	ELIARMNEFH ESLMAHVSLH ALQEPDGTEN QEPEAKPGAF GKLYNIINTV KELEEEPKAI 
2161:	DEPPKKTPEE KFRKVLIQTI VNWAEESQIE TPKLVREMFS LLVRQYDAVG ELIRALEKTY 
2221:	VINAKTKLDV AEMWVGLSQI RALLPVQMSQ EEEELMRKRL WKLVNNHTFF QHPDLIRVLR 
2281:	VHENVMAVMM NTLGRRAQAQ SDAQPASPPV AEDSKEKDTS HEMVVACCRF LCYFCRTGRQ 
2341:	NQKAMFDHFD FLLENSNNLL SRPSLRESTP LDVAYSSLME NTELALALRE HYLEKIAVYL 
2401:	SRRGLQSNSE LVEKGYPDLG WDPVEGERYL DFLRFCVWVN GESVEENANL VIRLLIRRPE 
2461:	YLGPALRGEG EGLLKAIVDA NKMSERIADR RKLREMEQEG DVSFSHPLPE SDDDEDYIDT 
2521:	GAAILNFYCT LVDLLGRCAP DAGVIALGKN ESLRARAILR SLVPLEDLQG VLSLRFTLNN 
2581:	PAAGGERPKS DMPSGLIPGH KQSVGLFLER VYGIETQELF YKLLEEAFLP DLRAATMLDR 
2641:	NDGCESDMAL SMNRYIGNSI LPLLIKHAYF YNEAENYASL LDATLHTVYR LSKNRMLTKG 
2701:	QREAVSGFLV ALTSAMQPSM LLKLLRKLTV DVSKLSEYTT VALRLLTLHY ERCAKYYGST 
2761:	GAGQGVYGAS SDEEKRLTMM LFSNIFDSLS KMDYEPELFG KALPCLIAIG CALPPDYSLS 
2821:	KNYDDEFYGK EQVAGDLDNP QYDPQPINTS SVALNNDLNT IVQKFSEHYH DAWASRKIGN 
2881:	GWVYGEGWSD SQKTHPRLKP YNMLNDYEKE RYKEPVRESL KALLAIGWSV EHSEVDIPST 
2941:	NRSSMRRQSK SGGRPPDLVT DSATPFNYNP HSVDMTNLTL SREMQNMAER LADNAHDIWA 
3001:	KKKKEELVTN GGGIHPQLVP YDLLTDKEKK RDRERSQEFL KYLQYQGYKL HRPSKAPQSD 
3061:	TEQTTTGVAI EPRFAYSLLE KLIQYIDRAA INMKLLKPST TFSRRTSFKT STRDIKFFSK 
3121:	VVLPLMEKYF STHRNYFIAV ATATNNVGAA SLEEKEMVAA LFCKLASLLR SRLAAFGPDV 
3181:	RITVRCLQVL VKGIDAKSLV KNCPEFIRTS MLTFFNNVAD DVGHTIMNLQ DGKYAHLRGT 
3241:	HLKTSTSLGY INGVLLPILT AKFDHLANCE YGADLLLDEI QVASYKMLGS LYALGTDASL 
3301:	THDRKYLKTE IERHKPALGS CLGAFSSTFP VAFLEPHLNK HNQFSLLNRI ADHSLEAQDI 
3361:	MQKMEQCMPT LETILGEVDQ FVESDKTYNE APHIIDVVLP LLCSYLPFWW AQGPDNVTPT 
3421:	GGNHVTMVTA EHMNQLLKNV LKLIKKNIGN ENAPWMTRIA THTQQIIINS SEELLRDSFP 
3481:	PLAERVRKRT DNMFHKEESL RGFIKSSTDD TSQVESQIQE DWQLLVRDIY SFYPLPIKYV 
3541:	DLQRNHWLRN NVPEAEELYN HVAEIFNIWS KSQYFLKEEQ NFISANEIDN MVLIMPTATR 
3601:	RVTAVVDGTP QAGGKKKKKH RDKKRDKDKE VQASLMVACL KRLLPVGLNL FAGREQELVQ 
3661:	HCKDRFLKKM SEQDVAEFAK TQLTLPDKID PADEMSWQHY LYSKLGSKSK TNITVETAEN 
3721:	KAKIIDDTVE RIVAMSKVLF GLHMIDHPQQ MSKNVYRSVV SIQRKRAVIA CFKQTSLHSL 
3781:	PRHRACNIFA RTYYELWLEE ENVGQEVMIE DLTQSFEDAE LKKSDGEEEG EKPDPLTQLV 
3841:	TTFCRGAMTE RSGALQEDPL YMSYAHIIAK SCGEEEEEGG GEEEEGGGEA EAEDEGRASI 
3901:	HEQEMEKQKL LFHQARLANR GVAEMVLLHI SASKGLPSEM VMKTLQLGIS ILRGGNIDIQ 
3961:	MGMLNHLKDK KDVGFFTSIA GLMNSCSVLD LDAFERNTKA EGLGVGLEGV AGEKNMHDAE 
4021:	FTCALFRFIQ LTCEGHNLDW QNYLRTQAGN TTTVNVVICT VGYLLRLQES IVDFYWHYSS 
4081:	KELIDPAGKA NFFKAISVAS QVFNTLTEVI QGPCTQNQQA LAHSRLWDAV GGFLFLFSHM 
4141:	QDKLSRHSSQ VNLLKELLSL QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESASNVELIL 
4201:	KYFDMFLKLK DLTSSASFQE IDANNDGWVL PKDFKEKMEQ QKSYTPEEIE FLLACCETNH 
4261:	DGKLNYIGFC DRFHEPAKEI GFNLAVLLTN LSEHMPNEPR LARFLETAGS VLNYFEPFLG 
4321:	RIEIMGGSKR IERVYFEIKE SNIEQWEKPQ IKESKRAFFY SIVTEGGDKE KLEAFVNFCE 
4381:	DAIFEMTHAS GLMAASEESV GGTKNREASY MYMGDDDDER AGKDPFRRGL QSVKDGIYAA 
4441:	FSSLSPSNMK AKIADLQQMP PAELAVGFFK MFFLLFYYLG YGMLVVIRYI FGVLLGLMRG 
4501:	PQTDEPPPEP TEEEKIGQLR HRLLATQSSR HLPALPPADD TGQIQVSAFG LDITKEDNEQ 
4561:	IQVKPHESPS TSTPSPGEEA EVSPDESADH PEEQRPPSLI DLLGGEQAKK QAQERMEAQA 
4621:	AKQAAMSAIE AESKKAVQVP APSALSQVDP SQYTRRAVSF LARNFYNLKY VALVLAFCIN 
4681:	FVLLFYKVST LDAEGGEGSG LGDIIAGSGS GSGSGSGDGG SGESEDDDAL EVVHIDEDFF 
4741:	YMEHVIKVAA VLHSIVSLAI LIGYYHLKVP LAIFKREKEI ARKLEFDGLY IAEQPENDDL 
4801:	KSHWDKLVIS AKSFPVNYWD KFVRKKVRAK YSETYDFDSI SNMLGMEKTS FSAQEEEGSK 
4861:	GLIHYIINID WRYQVWKAGV TITDNSFLYS LWYFSFSVMG NFNNFFFAAH LLDVAVGFKT 
4921:	LGTILQSVTH NGKQLVLTVM LLTIIVYIYT VIAFNFFRKF YVQEEDDEVN RNCHDMLTCF 
4981:	VFNLYKGVRA GGGIGDELEP PDGDDSEVYR IIFDITFFFF IIVILLAILQ GLIIDAFGEL 
5041:	RDQLESVKED MESNCFICGI NKDYFDKVPH GFDTHVQREH NLANYMFFLM HLINKPDTEY 
5101:	TGQETYVWNM YTQRCWDFFP VGDCFRKQYE DLMGE