1.A.3.1.4 Ryanodine receptor (RyR) of 5107 aas. Flubendiamine, a RyR-activating insecticide, induced Ca2+ release in hemocytes (Kato et al. 2009; Wu et al. 2013).
|
Accession Number: | R9R5D5 |
Protein Name: | Ryanodine receptor |
Length: | 5107 |
Molecular Weight: | 578230.00 |
Species: | Pieris rapae (Small white butterfly) [64459] |
Number of TMSs: | 4 |
Substrate |
calcium(2+) |
---|
1: MAEAEGGASE QDDVSFLRTE DMVCLSCTAT GERVCLAAEG FGNRHCFLEN IADKNIPPDL
61: SQCVFVIEQA LSVRALQELV TAAGSETGKG TGSGHRTLLY GNAILLRHLN SDMYLACLST
121: SSSQDKLASD VGLQEHSQGE ACWWTLHPAS KQRSEGEKVR VGDDLILVSV ATERYLHTTK
181: ENEVSIVNAS FHVTHWSVQP YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSTWNKDG
241: GLNIVVYEGG SVMSQARSLW RLELARTKWA GGFINWYHPM RIRHITTGRY LGVNDQNELY
301: LVSREEATTA SCAFCLRQEK NDQKVVLEDK DLEVIGAPII RYGDSTVIVQ HSETGLWLSY
361: KSYETKKKGL GKVEEKQAIL HEEGKMDDGL DFSRSQEEES RTARVIRKCS SLFTKFINGL
421: ETLQENRRHS MFFASVNLGE MVMCLEDLIN YFAQPEEDME HEEKQNRFRA LRNRQDLFQE
481: EGILNLILEA IDKINVITSQ GFLAGFLAGY ESGQSWDMIS VYLYQLLAAI IKGNHTNCAQ
541: FANSNRLNWL FSRLGSQASG EGTGMLDVLH CVLIDSPEAL NMMRDEHIKV IISLLEKHGR
601: DPKVLDVLCS LCVGNGVAVR SSQNNICDYL LPGKNLLLQT ALVDHVSSVR PNIFVGRVEG
661: SAVYQKWYFE ATMDHIEKTT HMMPHLRIGW ANTSGYVPYP GGGEKWGGNG VGDDLYSFGF
721: DGAYLWSGGR KIQVNKTHAE EPFIRKGDVI GCALNLTVPI INFMFNGVKV TGSFPNFNLE
781: RNVLPCHELS SKLKLPFSHG KRTTGRAKDT PGLPEGYSPL VESLLPQQIL NLEPCFYFGN
841: LSKRALAGPP LVQDDTAFVP TPVDTASITL SSYIEQIRDK LAENIHEMWA MNKIEAGWMY
901: GDQRDDLHKV HPCLVPFERL PAAEKRYDIQ LAVQTLKTIL ALGYYISLDK PPARIRNVRL
961: PNEPFMQSNG YKPAPLDLSA VTLTPKMDEL VDQLAENTHN LWARERIQQG WTYGLNEDPD
1021: MNRSPHLVPY PKVDDAIKKA NRDTASETVR TLLVYGYNLD PPTGEQHEAL LAEASRQKQA
1081: EFRTYRAEKN YAVSSGKWYF EFEILTAGPM RVGWAHADMP PGMMLGQDEN SWAFDGYNEE
1141: KVYSGSLESF GKQWAVGDVV GVFLDLIDKT ISFSLNGELL MDALGGETTF ADVQGDNFVP
1201: ACTLGVGQKA RLSYGQDVNS LKYFTTCGLQ EGYEPFCVNM NRDVTHWYTK DQPMFENTDE
1261: MIDTRIDVTR IPAGSDTPPC LKISHNTFET MEKANWEFLR LSLPVICHAE FIDESEKARR
1321: WVEIKDRQQI LMKEAVEAQM PAHIDQIMRS GFTMNDIKGL HYDENQEDVK IKRQPSRPPR
1381: KGSITRNVTI QNYNSQSGQN GMNRSTSEAE MSKYELGVQN LPEDTKKDKR GRSPFKFFRS
1441: KRGESGDRGK SRKSKTPDPY TDTEVSPDRA RRPNPQIRIS QANQRYNMQN RNDGANIYDS
1501: QGALSTNLTV PTPTQDRKQM TTATLDKSAT ETIGNEIFDA DCLKLINGYF YGVRIFPGQD
1561: PTHVYIGWVT TQYHLHSKDF NQNKVTKSSV IITDDYDRVI ESVNRQSCYM VRADELYNEV
1621: MAEATAKGAS QGMFIGCSVD TSTGTVSFTC EGKDTSIKFK MEPETKLFPA IFVEATSKEI
1681: LQIELGRSST SLPLSAAVLP TSDKHVNPQF PPRLKVQCLK PHQWARVPNQ FLQVHALKLS
1741: DIRGWSMLCE DAVSMLALHI PEEDRCIDIL ELIEMDKLLS FHAHTLTLYA ALCYQSNYRA
1801: AHALCQHVDQ KQLLYAIRSQ YMSGPLRQGF YDLLIALHLE SHATTMEACK NEFVIPLGPE
1861: LKALYEDREM CHSLRSLQTE SVRPQMNMTN IAENISDISN LYFPYFPLEV VREFVMQALA
1921: EAVETNQVHS RDPTGGSNEN LFLPLIKLVD RLLLVGMMRD EDVEKLLIMI NPETWDPTFD
1981: KEGKDEHRKG LLHMKMAEGA KLQMCYLLQH LNDIQLRHRV ESIIAFAHDF VGELQTDQLR
2041: RYTEIKQSDL PSAVAAKKTR EFRCPPREQM NAILSFKHLE DEDPENCPCG EELIARMNDF
2101: HDALMSHVSL SALQEPDGDQ SNEPEVKPGA FGKLYNIINT VKELEDDAKA LEEEKKKTPE
2161: EKFRKVLIQT IVNWAEESRI ETPKLVREMF SLLVRQYDAV GELIRALEKT YVINAKTKLD
2221: VAEMWVGLSQ IRALLPVQMS QEEEELMRKR LWKLVNNHTF FQHPDLIRVL RVHENVMAVM
2281: MNTLGRRAQA QSDAPATSPP TPEDKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD
2341: FLLENSNILL ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE
2401: LIEKGYPDLG WDPVEGERYL DFLRFCVWVN DESVEENANL VIRLLIRRPE CLGPALRGEG
2461: EGLLKAIVDA NKMSERIADR RKLRDLEQEG DISFSHPLPE SEDDEDYIDT GAAILNFYCT
2521: LVDLLGRCAP DAGVIALGKN ESLRARAILR SLVPLEDLQG VLSLRFTLNN PAAGEERPKS
2581: DMPSGLIPGH KQSVGLFLER VYGIETQELF YRLLEEAFLP DLRAATMLDR NDGCESDMAL
2641: SMNRYIGNSI LPLLIKHANF YNEAENYASL LDATLHTVYR LSKNRMLTKG QREAVSDFLV
2701: ALTSAMQPSM LLKLLRKLKL TVDVSRLSEY TTVALRLLTL HYERCAKYYG STGGQGSYGS
2761: SSDEEKRLTM MLFSNIFDSL SKMDYEPELF GKALPCLIAI GCALPPDYSL SKNYDDEFYG
2821: KDSQASGADN PQYDPQPINT SSVALNNDLN TIVQKFSEHY HDAWASRKIE NGWVYGENWS
2881: DSQKTHPRLK PYNMLNDYEK ERYKEPVRES LKALLAIGWS VEHSEVDIPS NNRSSMRRQS
2941: KSGIDSATPF NYNPHPVDMT NLTLSREMQN MAERLADNAH DIWAKKKKEE LVTSGGGIHP
3001: QLVPYDLLTD KEKKKDRERS QELLKYLQYQ GYKLHRPSKA SQIDTEQTTT GVAIELRFAY
3061: SLLEKLIQYI DRATINMKLL KPSTTFSRRS SFKTSTRDIK FFSKVVLPLM EKYFSTHRNY
3121: FIAVATATNN VGAASLKEKE MVAALFCKLA SLLRSRLAAF GPDVRITVRC LQVLVKGIDA
3181: KPLVKNCPEF IRTSMLTFFN NLADDLGHTI FNLQEGKYAH LRGTHLKTST SLGYINGVML
3241: PILTAMFDHL ANCEYGADLL LDEIQVASYK MLGSSYTLGT DVTLTHDRKY LKTEIERHKP
3301: ALGSCLGAFS STFPVAFLEP HLNKHNQFSL LNRIADHSLE AQDIMAKMEQ SMPTLETILN
3361: EVDHFVESDK TYSEAPHIID VVLPLLCSYL PFWWAQGPDN VTPTGGNHVA MVTADHMNQL
3421: LKNVLKLIKK NIGNENAPWM TRIATYTQQI IINSSEELLR ESFLPLAERV RKRTDNMFHK
3481: EESLRGFIKS STDDTSQVES QIQEDWQLLV RDIYSFYPLL IKYVDLQRNH WLRNNVPEAE
3541: ELYNHVAEVF NIWSKSQYFL KEEQNFISAN EIDNMVLIMP TATRRVTTVV DGTQQGGGKK
3601: KKKHRDKKRD KDKEVQASLM VACLKRLLPV GLNLFAGREQ ELVQHCKDRF LKKMSEQDVA
3661: EFAKTQLTLP DKIDPADEMS WQHYLYSKLG SKSKTAITVE TSENKVKIID DTVERIVAMS
3721: KVLFGLHMID HPQQMSKNVY RSVVSIQRKR AVIACFRQTS LHSLPRHRAC NIFARTYYEL
3781: WVEEENIGQE VMIEDLTQTF EDAELKKSDI VEEEGKPDPL TQLVTTFCRG AMTERSGALQ
3841: EDPLYMSYAH IIAKSCGEEE EEGGEEEEGG GEPEGEDEGK SSIHEQEMEK QKLLFHQARL
3901: ANRGVAEMVL LHISASKGVP SDMVMKTLQL GISILRGGNI DIQMGMLNHL KDKKDVGFFT
3961: SIAGLMNSCS VLDLDAFERN TKAEGLGVGL EGAAGEKNMH DAEFTCALFR FIQLTCEGHN
4021: LEWQNYLRTQ AGNTTTVNVV ICTVDYLLRL QESIMDFYWH YSSKELIDPA GKANFFKAIG
4081: VASQVFNTLT EVIQGPCTQN QQALAHSRLW DAVGGFLFLF SHMQDKLSKH SSQVDLLKEL
4141: LNLQKDMITM MLSMLEGNVV NGTIGKQMVD TLVESASNVE LILKYFDMFL KLKDLTSSAS
4201: FKEIDANNDG WVLPKDFKEK MEQQKSYSPE EIEFLLACCE TNHDGKLDYI GFCDRFHEPA
4261: KEIGFNLAVL LTNLSEHMPN EPRLARFLET AGSVLNXFEP FLGRIEIMGG SKRIERVYFE
4321: IKESNIEQWE KPQIKESKRA FFYSIVTEGG DKEKLEAFVN FCEDAIFEMT HASGLMAASE
4381: ESASGPKNRE AAYTYLGDDD DERAGKDPFR RGYQSVKDAI AATFSFLSPS NIKAKIADMQ
4441: QMPPAELLVG FLKLFFYLFY YIGYGFVVVI RYIFGVLLGL MRGPHVEEPP PQEPTEEEKI
4501: GPSRHLPALP ATDDTGQMQV SAFGLDITKE DNGQLQVKPH ESPTTSTPSS GEEAEVSPDE
4561: SIEHTEEQQP PSLIDLLGGE QAKKQAQERV EAQAAQQAAM SAIEAESKKA VQVPAPSALS
4621: QVDLSQYTKR AVSFLARNFY NLKYVALVLA FCINFVLLFY KVSIPDSDKE GSGIGDIISG
4681: SGSGQGSGSG EGSGESEDDD SLEVVRIDED FFYMEHVIKM AAALHSIVSL AILIGYYHLK
4741: VPLAIFKRGK DIARRLEFDG LYIAEQPEDD DLKSHWDKLV ISAKSFPVNY WDKFIKKKVR
4801: AKYSETYDFD SISNMLGMEK TSFSAQEDEG NKGLWNYIVN IDWRYQVWKA GVTITDNSFL
4861: YSLWYFSFSV MGNFNNFFFA AHLLDVAVGF KTLRTILQSV THNGKQLVLT VMLLTIIVYI
4921: YTVIAFNFFR KFYVQEEDDE INRNCHDMLS CFVFNLYKGV RAGGGIGDEL EPPDGDDSEV
4981: YRIIFDISFF FFVIIILLAI LQGLIIDAFG ELRDQLESVK EDMESNCFIC GINKDYFDKV
5041: PHGFDTHVQR EHNLANYMFF LMHLINKPDT EYTGQETFVW NMYTQRCWDF FPVGDCFRKQ
5101: YEDVMGE