1.A.4.1.12
TrpC4 of 977aas. In epidermal keratinocytes, a
syndecan-TRPC4 complex controls adhesion, adherens junction composition, and early differentiation
in vivo and in vitro (Gopal et al. 2015). Constitutively active TRPC1/C4-dependent background Ca2+ entry fine-tunes Ca2+ cycling
in beating adult cardiomyocytes. Double TRPC1/C4-gene inactivation protects against development of
maladaptive cardiac remodelling without altering cardiac or extracardiac functions contributing to
this pathogenesis (Camacho Londoño et al. 2015). A cryo-EM structure of TRPC4 in its unliganded (apo) state has beeen solved to an overall resolution of 3.3 A. It reveals a unique architecture with a long pore loop stabilized by a disulfide bond. Beyond the shared tetrameric six-transmembrane fold, the TRPC4 structure deviates from other TRP channels with a unique N-terminal cytosolic domain which forms extensive aromatic contacts with the TRP and the C-terminal domains (Duan et al. 2018).
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| Accession Number: | Q9UBN4 |
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| Protein Name: | Short transient receptor potential channel 4 |
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| Length: | 977 |
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| Molecular Weight: | 112101.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+), monoatomic monocation |
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1: MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK
61: ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK
121: PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE
181: CVSSSDVDSL RHSRSRLNIY KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE
241: YEELSRQCKQ FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF
301: VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA PKSPLGLFIR
361: KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT IVEWMILPWV LGFIWGEIKQ
421: MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS ALNPRESWDM WHPTLVAEAL
481: FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY
541: YEETKGLTCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM
601: FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI
661: PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA
721: MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLRGSKLS TIQSANASKE SSNSADSDEK
781: SDSEGNSKDK KKNFSLFDLT TLIHPRSAAI ASERHNISNG SALVVQEPPR EKQRKVNFVT
841: DIKNFGLFHR RSKQNAAEQN ANQIFSVSEE VARQQAAGPL ERNIQLESRG LASRGDLSIP
901: GLSEQCVLVD HRERNTDTLG LQVGKRVCPF KSEKVVVEDT VPIIPKEKHA KEEDSSIDYD
961: LNLPDTVTHE DYVTTRL