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1.A.4.1.3
TRPC1 store-operated Ca2+ channel (Liu et al., 2003) (activated by the metabotropic [G- protein-dependent] glutamate receptor, mGluR1) (Kim et al., 2003) (controls salivary gland fluid secretion in mice (Liu et al., 2007a).  Constitutively active TRPC1/C4-dependent background Ca2+ entry fine-tunes Ca2+ cycling in beating adult cardiomyocytes. Double TRPC1/C4-gene inactivation protects against development of maladaptive cardiac remodelling without altering cardiac or extracardiac functions contributing to this pathogenesis (Camacho Londoño et al. 2015). Regulated by drebrin (DBN1; 649 aas; Q16643) (Pabon et al. 2017). TRPC1 null mutations exacerbate memory loss and apoptosis induced by amyloid-beta (Li et al. 2018). Pulsed focused ultrasound (pFUS) acoustic radiation forces mechanically activate a Na+-containing TRPC1 (TC# 1.A.4..1.3) channel generating current upstream of voltage-gated Ca2+ channels (VGCC) rather than directly opening VGCC (Burks et al. 2019).

Accession Number:P48995
Protein Name:TRPC1
Length:793
Molecular Weight:91212.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate calcium(2+)

Cross database links:

RefSeq: NP_003295.1   
Entrez Gene ID: 7220   
Pfam: PF00520    PF08344   
OMIM: 602343  gene
KEGG: hsa:7220   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005515 F:protein binding
GO:0015279 F:store-operated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0051480 P:cytosolic calcium ion homeostasis
GO:0051281 P:positive regulation of release of sequester...
GO:0051592 P:response to calcium ion
GO:0055085 P:transmembrane transport

References (9)

[1] “Molecular cloning of a widely expressed human homologue for the Drosophila trp gene.”  Zhu X.et.al.   7589464
[2] “TRPC1, a human homolog of a Drosophila store-operated channel.”  Wes P.D.et.al.   7568191
[3] “Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.”  Zitt C.et.al.   8663995
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.”  Lockwich T.P.et.al.   10766822
[6] “TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells.”  Xu S.-Z.et.al.   11139478
[7] “Subunit composition of mammalian transient receptor potential channels in living cells.”  Hofmann T.et.al.   12032305
[8] “MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.”  Lussier M.P.et.al.   15757897
[9] “RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.”  Lussier M.P.et.al.   17850865

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 
61:	YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQS ADALLVAIDS 
121:	EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK 
181:	QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL 
241:	SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 
301:	LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF 
361:	WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYNE DKKNTMGPAL 
421:	ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKVVAHNKF 
481:	HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF 
541:	LGMFLLVLFS FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 
601:	LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW 
661:	KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW 
721:	RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG 
781:	FRTSKYAMFY PRN