1.A.4.1.9
Trp-1 isoform channel; controls nicotne-dependent behavior (Xiao and Xu 2009). TRPC orthologues TRP-1 and -2 genetically
complement the loss of syndecan by suppressing neuronal guidance and locomotory defects related to
increases in neuronal calcium levels. The widespread and conserved syndecan-TRPC axis therefore fine
tunes cytoskeletal organization and cell behavior (Gopal et al. 2015).
|
| Accession Number: | Q27GV1 |
|---|
| Protein Name: | Protein TRP-1, isoform b |
|---|
| Length: | 1047 |
|---|
| Molecular Weight: | 120524.00 |
|---|
| Species: | Caenorhabditis elegans [6239] |
|---|
| Number of TMSs: | 9 |
|---|
| Substrate |
calcium(2+) |
|---|
1: MLSAAGRRFS RCAPSPRPRR NYALANIPPP AAVHIRTNDM ISPEERRKSR VKSLKHAQLL
61: HGYYILSNNL FRFLEAAELG NKPTLQECLD YDGDRRLNVN CLDSMGRTAL EIAVDNENME
121: VVELLLQQPD IRIGNALLCA IREGVYRLVE VLVNHPNITR EMLGDGWSQA LDPSEAASAE
181: YSSDISPVIL AAQLNQFEIL QMLIRKDASI EKPHRHSCIC ETCDRERLND SLQYSLKRIN
241: TFRALASPAW MSLTSPDPIL SAFKLSWDLQ RLAFEEHEFK ETYLQLSEQC KQYSCDLLSQ
301: CRSSEEVIAI LNKDGNVNDD NIDVWASKLS LSRLKLAIKY EQKAFVSHPH CQQLLTSIWY
361: EGIPYRQRSG TWANFFLYAF LLFLWPIFCL MYILMPKSRL GRLVRSPFMK FFYYSVSFAT
421: FLGLLTWATF EDYRYEKGER GGMTRASDRG PPATWVESLV FTWVIGMLWS EIKQLWEEGF
481: KRYMRQWWNW LDFLMICLYL CTISIRLSAY YIFTYREDPY RYTVRTYWTS EEPMLVAEAL
541: FAVGNVFSFA RIIYLFQTNP YLGPLQISLG CMLVDVAKFC FIFVLIISSF SIGLAQLYWY
601: YDPNTDVCLP GATCKHSSNV FSSIADSYLT LLWSLFSITK PEDTDVVENH KITQWVGQGM
661: FIMYHCTSII VLLNMLIAMM SHSFQIINDH ADLEWKFHRT KLWMAHFDEG SSLPPPFNII
721: VTPKSLIYVM NCLFNTVRWL LGKYTYQKNR NRATIRRPGY SRKRNEMEKS GGHDDDSLKP
781: LTYADIITRL VARFIHQTKK DMKMDGVNED DLHEIKQDIS SLRYELRDDR RREIVRSSSH
841: IDAVKRDIMR TMSTTSRRPY GGSMRLPKTR PSVAEESEED DKSDETSSTD EEADETRSRK
901: SSVLYIPPVN STLPGIISEE APVKKSTKRR ASEADSKLPD RPLSDTYTSS FTPKLLPVFA
961: QPPHSALRKT DTSMSFPING TALDTSIVKP PRGVLRASQE NLPAVELIET LKKEMNEKLD
1021: RLISGISENV KSPSPASHSH VGFNVEK