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1.A.4.2.7 Intestinal endocyte Ca²⁺ (Sr²⁺; Ba²⁺) entry channel, CaT1. Excision of the Trpv6 gene leads to severe defects in epididymal Ca²⁺ absorption and male fertility as does the single D541A pore mutation (Weissgerber et al., 2012).
Accession Number:	Q9R186
Protein Name:	CaT1
Length:	727
Molecular Weight:	83236.00
Species:	Rattus norvegicus (Rat) [10116]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	barium(2+), strontium(2+), calcium(2+)

Structure:
RefSeq:	NP_446138.1
Entrez Gene ID:	114246
Pfam:	PF00023 PF00520
KEGG:	rno:114246
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005227 F:calcium activated cation channel activity GO:0005262 F:calcium channel activity GO:0005516 F:calmodulin binding GO:0006816 P:calcium ion transport GO:0055085 P:transmembrane transport
References (2) [1] “Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption.” Peng J.-B.et.al. 10428857 [2] “CaT1 manifests the pore properties of the calcium-release-activated calcium channel.” Yue L.et.al. 11287959
5iwk 5IWP 5IWR 5IWT 5WO6 5WO7 5WO8 5WO9 5WOA 6BOB [...more]

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MGWSLPKEKG LILCLWNKFC RWFHRRESWA QSRDEQNLLQ QKRIWESPLL LAAKENNVQA 
61:	LIKLLKFEGC EVHQKGAMGE TALHIAALYD NLEAAMVLME AAPELVFEPM TSELYEGQTA 
121:	LHIAVINQNV NLVRALLARG ASVSARATGS VFHYRPHNLI YYGEHPLSFA ACVGSEEIVR 
181:	LLIEHGADIR AQDSLGNTVL HILILQPNKT FACQMYNLLL SYDGGDHLKS LELVPNNQGL 
241:	TPFKLAGVEG NIVMFQHLMQ KRKHIQWTYG PLTSTLYDLT EIDSSGDDQS LLELIVTTKK 
301:	REARQILDQT PVKELVSLKW KRYGRPYFCV LGAIYVLYII CFTMCCVYRP LKPRITNRTN 
361:	PRDNTLLQQK LLQEAYVTPK DDLRLVGELV SIVGAVIILL VEIPDIFRLG VTRFFGQTIL 
421:	GGPFHVIIVT YAFMVLVTMV MRLTNSDGEV VPMSFALVLG WCNVMYFARG FQMLGPFTIM 
481:	IQKMIFGDLM RFCWLMAVVI LGFASAFYII FQTEDPDELG HFYDYPMALF STFELFLTII 
541:	DGPANYDVDL PFMYSITYAA FAIIATLLML NLLIAMMGDT HWRVAHERDE LWRAQVVATT 
601:	VMLERKLPRC LWPRSGICGR EYGLGDRWFL RVEDRQDLNR QRIRRYAQAF QQQDDLYSED 
661:	LEKDSGEKLE MARPFGAYLS FPTPSVSRST SRSSTNWDRL RQGALRKDLQ GIINRGLEDG 
721:	EGWEYQI

1.A.4.2.7
Intestinal endocyte Ca²⁺ (Sr²⁺; Ba²⁺) entry channel, CaT1. Excision of the Trpv6 gene leads to severe defects in epididymal Ca²⁺ absorption and male fertility as does the single D541A pore mutation (Weissgerber et al., 2012).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.4.2.7Intestinal endocyte Ca2+ (Sr2+; Ba2+) entry channel, CaT1. Excision of the Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility as does the single D541A pore mutation (Weissgerber et al., 2012).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.4.2.7
Intestinal endocyte Ca²⁺ (Sr²⁺; Ba²⁺) entry channel, CaT1. Excision of the Trpv6 gene leads to severe defects in epididymal Ca²⁺ absorption and male fertility as does the single D541A pore mutation (Weissgerber et al., 2012).