1.A.4.3.3
TrpV-type Osm-2 (OSM2) chemo-, osmo- and touch sensation receptor channel (Xiao and Xu 2009). It is also called OCR-2. To survive, C. elegans depends on sensing soluble chemicals with transmembrane proteins (TPs) in the cilia of its chemosensory neurons. Cilia rely on intraflagellar transport (IFT) to facilitate the distribution of cargo, such as TPs, along the ciliary axoneme (van Krugten et al. 2022). IFT and diffusion in ciliary dynamics contribute to ciliary signal transduction and chemosensing.
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| Accession Number: | O61220 |
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| Protein Name: | Protein OCR-2 |
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| Length: | 900 |
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| Molecular Weight: | 101973.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 5 |
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| Substrate |
calcium(2+) |
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1: MGSSSSTQSS MNNFVGMGRL REDMKIYQLV DMHGGGELLP WLRYAIISSD TSFIDAYLET
61: KVKDFLYNGG KGKLVTVTEL VKLRNKERNE RLGAFSRKKG KGKSGPNVLD DFNQEGENVG
121: DLKKALKLLD GGGKGGRNES KYREISWKLE ERGSMGETII GCCLLHASDI HNALVLKILD
181: YYPKLLNDIH ISEDFYGLSP LHQAIINTDC KLVYKFLKLG ADVNSRCYGA FFCADDQKAS
241: RTDSLEHEYV ELSLKTNYTG NMYLGEYPLS FAACLNQPES FRLLLAFKAN PNAQDTNGNS
301: VLHMCVIHEN MAMFKLALEC GASLRTVNKQ SLSPLTLAAK LAKKEMFDEI LELEGDSVWA
361: YGDASSTAYP LAKIDTINET TGELNEASAL SLVVYGQTVE HLELLDGLLD TLLEAKWEAF
421: AKRNMIVSFT AFTLYYICFV TAFTLRPIGF STEMLTEGWI NRYSEPFPGR YGKNSTLQQV
481: KPVINATSRG LVEWSEPLSQ CHLRNYWDPD IPFANSYIRL VFELFVVIGI CVQVFLDFRD
541: IKRIGRKKWW NVLTAFPAKI TFKLTYFLVL AMIPTRLACD LSPVLLVVDN VLITVTMIFT
601: TVHYLYYCRV IRFVGPFVLM VYTIIATDIF RFMLIYGIFL MGFSQSFSLI FLSCEREANV
661: IKKLITDQSE ASEGSDNKFN LTRQISAYDT AIVKNAEVFE NVMQSPIEAF VRTFILTIGE
721: FTVLYRNLAL CPANTMVWIG KVVFILFELF VSIMQFNMLI AMMTRTYETI FQTQLEYKRQ
781: RAQVILMLEL SLSPKERHQY LLKYSRPTGT NKKTRSLVVS KKSAFSRDSK KGQKVLEEKM
841: KKMIEEKKAV LKRKMKDMEI KEGIRPVTGY SRTPRPHTQY MNRGAGGGAN GVQNGNGAAH