1.A.4.5.10
TrpCC family member, Gon2. Required for initiation and continuation of postembryonic mitotic cell division of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. Probably a cation channel that functions together with Gem1 (TC#2.A.1.13.22) (Kemp et al. 2009).
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| Accession Number: | Q93971 |
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| Protein Name: | Transient receptor potential channel |
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| Length: | 2032 |
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| Molecular Weight: | 229063.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cation |
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1: MMSDDMLDEN DENFACQDVD EIIIYVPEFA GYREVNIDTA VSVCPTPIQQ ARRESSCRNL
61: EMRRRFEKLR REKKEEKKLL ADDEKDFDED DDVFEDGEGL QMRTFQPNAS IRDENGSMPS
121: LLPRTAPIKK TRKHRRRRSG SFTGGVYPRK GHRNRSLLGH AIPPPNVHSA DWRDMLAITD
181: NKDDKLMKTL GVTRYLQSKG GDQVPPTSTT TGGAGGDGNA VPTTSQAQAQ TFNSGRQTTG
241: MSSGDRLNED VSATANSAQL VLPTPLFNQM RFTESNMSLN RHNWVRETFT RRECSRFIAS
301: SRDLHKCGCG RTRDAHRNIP ELTSEFLRQK RSVAALEQQR SISNVNDDIN TQNMYTKRGA
361: NEKWSLRKHT VSLATNAFGQ VEFQGGPHPY KAQYVRVNFD TEPAYIMSLF EHVWQISPPR
421: LIITVHGGTS NFDLQPKLAR VFRKGLLKAA STTGAWIITS GCDTGVVKHV AAALEGAQSA
481: QRNKIVCIGI APWGLLKKRE DFIGQDKTVP YYPSSSKGRF TGLNNRHSYF LLVDNGTVGR
541: YGAEVILRKR LEMYISQKQK IFGGTRSVPV VCVVLEGGSC TIRSVLDYVT NVPRVPVVVC
601: DGSGRAADLL AFAHQNVTED GLLPDDIRRQ VLLLVETTFG CSEAAAHRLL HELTVCAQHK
661: NLLTIFRLGE QGEHDVDHAI LTALLKGQNL SAADQLALAL AWNRVDIARS DVFAMGHEWP
721: QAALHNAMME ALIHDRVDFV RLLLEQGINM QKFLTISRLD ELYNTDKGPP NTLFYIVRDV
781: VRVRQGYRFK LPDIGLVIEK LMGNSYQCSY TTSEFRDKYK QRMKRVKHAQ KKAMGVFSSR
841: PSRTGSGIAS RQSTEGMGGV GGGSSVAGVF GNSFGNQDPP LDPHVNRSAL SGSRALSNHI
901: LWRSAFRGNF PANPMRPPNL GDSRDCGSEF DEELSLTSAS DGSQTEPDFR YPYSELMIWA
961: VLTKRQDMAM CMWQHGEEAM AKALVACRLY KSLATEAAED YLEVEICEEL KKYAEEFRIL
1021: SLELLDHCYH VDDAQTLQLL TYELSNWSNE TCLALAVIVN NKHFLAHPCC QILLADLWHG
1081: GLRMRTHSNI KVVLGLICPP FIQMLEFKTR EELLNQPQTA AEHQNDMNYS SSSSSSSSSS
1141: SSSSSSDSSS FEDDDDENNA HNHDQKRTRK TSQGSAQSLN ITSLFHSRRR KAKKNEKCDR
1201: ETDASACEAG NRQIQNGGLT AEYGTFGESN GVSPPPPYMR ANSRSRYNNR SDMSKTSSVI
1261: FGSDPNLSKL QKSNITSTDR PNPMEQFQGT RKIKMRRRFY EFYSAPISTF WSWTISFILF
1321: ITFFTYTLLV KTPPRPTVIE YILIAYVAAF GLEQVRKIIM SDAKPFYEKI RTYVCSFWNC
1381: VTILAIIFYI VGFFMRCFGS VAYGRVILAC DSVLWTMKLL DYMSVHPKLG PYVTMAGKMI
1441: QNMSYIIVML VVTLLSFGLA RQSITYPDET WHWILVRNIF LKPYFMLYGE VYADEIDTCG
1501: DEAWDQHLEN GGPVILGNGT TGLSCVPGYW IPPLLMTFFL LIANILLMSM LIAIFNHIFD
1561: ATDEMSQQIW LFQRYKQVME YESTPFLPPP LTPLYHGVLI LQFVRTRLSC SKSQERNPMF
1621: DFSLKLFLDN DQIEKLHDFE EDCMEDLARQ KLNEKNTSNE QRILRADIRT DQILNRLIDL
1681: QAKESMGRDV INDVESRLAS VEKAQNEILE CVRALLNQNN APTAIGRCFS PSPDPLVETA
1741: NGTPGPLLLK LPGTDPILEE KDHDSGENSN SLPPGRIRRN RTATICGGYV SEERNMMLLS
1801: PKPSDVSGIP QQRLMSVTSM DPLPLPLAKL STMSIRRRHE EYTSITDSIA IRHPERRIRN
1861: NRSNSSEHDE SAVDSEGGGN VTSSPRKRST RDLRMTPSSQ VEESTSRDQI FEIDHPEHEE
1921: DEAQADCELT DVITEEEDEE EDDEEDDSHE RHHIHPRRKS SRQNRQPSHT LETDLSEGEE
1981: VDPLDVLKMK ELPIIHQILN EEEQAGAPHS TPVIASPSSS RADLTSQKCS DV