1.A.4.5.13
TRPM8 of the collared flycatcher of 1103 aas. It is 83% identical to the human ortholog. Its structure has been determined to ~4.1 Å resolution by cryo EM (Yin et al. 2018). The structure reveals a three-layered architecture. The amino-terminal domain with a fold
distinct among known TRP structures, together with the carboxyl-terminal
region, forms a large two-layered cytosolic ring that extensively
interacts with the transmembrane channel layer. The structure suggests
that the menthol-binding site is located within the voltage-sensor-like
domain and thus provides a structural glimpse of the design principle of
the molecular transducer for cold and menthol sensation (Yin et al. 2018).
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| Accession Number: | U3JD03 |
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| Protein Name: | Transient receptor potential cation channel subfamily M member 8 |
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| Length: | 1103 |
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| Molecular Weight: | 127545.00 |
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| Species: | Ficedula albicollis (Collared flycatcher) [59894] |
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| Number of TMSs: | 8 |
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| Substrate |
sodium(1+), potassium(1+), rubidium(1+) |
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1: TLFQVSMGSM RHRRNGNFES SRLLYSSMSR SIDVACSDAD LANFIQENFK KRECVFFTKD
61: TKSMGNLCKC GYPENQHIEG TQVNTTEKWN YKKHTKELPT DAFGDIQFEN LGKRGKYIRL
121: SCDTDSETLY DLMTQHWHLK TPNLVISVTG GAKNFALKPR MRKIFSRLIY IAQSKGAWIF
181: TGGTHYGLMK YIGEVVRDNT ISRSSEENVV AIGIAAWGMI SNRETLIRTA DSDGSYLAHY
241: IMDDLKRDPL YCLDNNHTHL LLVDNGTHGH PTIEAKVRTQ LEKYISERVI PESNYGGKIP
301: IVCFAQGGGK ETLKSINVAI KSKIPCVVVE GSGRIADVIA SLVEAEGTLA SSCVKESLLR
361: FLPRTISRLS EEETESWIKW IKEVLESPHL LTVIKIEEAG DEIVSNAISF ALYKAFSTNE
421: HDRDNWNGQL KLLLEWNQLD LASDEIFTND RNWESADLQD VMFTALVKDR PKFVRLFLEN
481: GLNLRKFLTT EVLRELYTNN FSSLVFKNLQ IAKNSYNDAL LTFVWKMVED FRRGFKRYYK
541: NSKDEMEIEL SEECPITRHP LQALFIWSVL QNKKELSKVI WEQTRGCTLA ALGASKLLKS
601: MAKVKNDINA AGESEELANE YETRAVELFT ECYSNDEDLA EQLLTYSCEA WGGSNCLELA
661: VEARDQQFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF FFPLIGCGFI SFRKKPVEKT
721: KKLFLYYVSF FTSPFVVFSW NVIFYIAFLL LFAYVLLMDF QKEPTALEII LYVLVFILLC
781: DEVRQWYMNG SKYFSDLWNV MDTLAIFYFI AGIVFRLHSD ESSWYSGRVI FCLDYIVFTL
841: RLIHIFTVSR NLGPKIIMLQ RMMIDVFFFL FLFAVWMVAF GVARQGILRK NEHRWEWIFR
901: SVIYEPYLAM FGQYPDDIDG TTYNFDHCTF SGNESKPLCV ELDANNQPRF PEWITIPLVC
961: IYMLSTNILL VNLLVAMFGY TVGSVQENND QVWKFQRFFL VQEYCSRLTI PFPFVIFAYI
1021: FMVMRKCFKC CCKKESKEPS VCCSRNEDNE ILAWEAVMKE NYLVKINTKA SDSSEEMVHR
1081: FRQLDAKLSD LKGLLKEISS KIK