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1.A.4.5.14
TrpM5 of 1165 aas and 8 - 10 TMSs. cryo-EM structures have been solved in an apo closed state, a Ca2+-bound open state, and an antagonist-bound inhibited state. Ruan et al. 2021 defined two novel ligand binding sites: a Ca2+ site (CaICD) in the intracellular domain and an antagonist site in the transmembrane domain (TMD). The CaICD site is unique to TRPM5 and has two roles: modulating the voltage dependence and promoting Ca2+ binding to the CaTMD site, which is conserved throughout TRPM channels. Conformational changes initialized from both Ca2+ sites cooperatively open the ion-conducting pore. The antagonist NDNA wedges into the space between the S1-S4 domain and the pore domain, stabilizing the transmembrane domain in an apo-like closed state (Ruan et al. 2021). It and phospholipase C-β2 colocalize in taste receptor cells (Yoshida et al. 2007).

Accession Number:S5UH55
Protein Name:Transient receptor potential melastatin 5
Length:1165
Molecular Weight:132641.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVEKSSERFD KQMAGRLGDI DFTGVSRTRG KFVRVTSSTD PAEIYQILTK QWGLAPPHLV 
61:	VALMGGDEVA QLKPWLRDTL RKGLVKAAQS TGAWILTSGL RFGITKNLGQ AVRDHSLAST 
121:	SPKVRVVAIG IAPWNMIQNR DLLLSAKPDH PATYPTEDLP YGAVYSLDCN HSHFILVDED 
181:	PKRPGATGEM RVKMLKHISL QRTGYGGTGS IEIPVLCLLV HGEPRILQKM YKNIQNSIPW 
241:	LILAGSGGVA DILVTLMDRG CWDADIVQEL LINTFPDGLH STEITSWTKL IQRILDHGHL 
301:	LTVHDPEQDS ELDTVILKAL VKACKSQSQE AQDFLDELKL AVAWNRVDIA KSEIFSGDVQ 
361:	WSAQDLEEVM MEALVNDKPD FVRLFVDNGV NIKQFLTYGR LQELYCSVSE KNLLHTLLLK 
421:	KNQERQAQLA RKRMSGNPNN ELGDRKFRFT FHEVSKVLKD FLDDTCKGFY QKLPAERMGK 
481:	GRLFHSQKNL PDMDRRCEHP WRDLFLWAIL QNRQEMANYF WAMGPEAVAA ALVGCKIMKE 
541:	MAHLATEAES ARSMKNAKYE QFAMDLFSEC YSNSEDRAYS LLVRKTCCWS KATVLNIATL 
601:	AEAKCFFAHD GVQALLTKVW WGAMRTDTSI SRLVLTFFIP PLVWTSLIKF NPEEQVSKDE 
661:	GEPFAELDSL ETEQALLLTD GDPVAGEGSA ETAARSCSAT FIRVVLRRWN RFWSAPVTVF 
721:	MGNVIMYFAF LILFSYVLLL DFRPPPPYGP SAAEIILYFW VFTLVLEEIR QSFFTDEDMS 
781:	ILKKMKLYVE DNWNKCDMVA ISLFVVGLSC RMAMSTYEAG RTVLALDFMV FTLRLIHIFA 
841:	IHKQLGPKII IVERMIKDVF FFLFFLSVWL IAYGVTTQAL LHPNDPRIDW VFRRALYRPY 
901:	LHIFGQIPLE EIDAAKMPDD NCTTDVQEII LGTLPPCPNI YANWLVILLL VIYLLVTNVL 
961:	LLNLLIAMFS YTFQVVQENA DIFWKFQRYN LIVEYHSRPA LAPPFIIISH ITQALLSFIK 
1021:	KTENTQDLLE RELPSGLDQK LMTWETVQKE NYLAKLEHEH RESSGERLRY TSSKVQTLLR 
1081:	MVGGFKDQEK RMATVETEVR YCGEVLSWIA ECFHKSTLKC DRDAPKAPRS IAGSSRDQQP 
1141:	QGAKRQQPGG HPAYGTDKKL PFIDH