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1.A.4.5.2
Melastatin 1 or transient receptor potential melastatin-1 (TRPM1; LTRPC1, MLSN, MLSN1) (a non-selective, Ca2+-permeable cation channel, implicated in cell death (Wilkinson et al., 2008).  Required for dim light vision.  Purified TRPM1 is mostly dimeric. The three-dimensional structure of TRPM1 dimers is characterized by a small putative transmembrane domain and a larger domain with a hollow cavity (Agosto et al. 2014). Since dimers are not likely to be functional ion channels, the authors suggested that additional partner subunits participate in forming the transduction channel required for dim light vision and the ON pathway.  The N-terminal region of TRPM1 (residues L242 to E344) regulates activity by direct interaction by the S100A1 calcium-binding protein (TC# 8.A.81) (Jirku et al. 2016). TRPM1 is required for synaptic transmission between photoreceptors and the ON subtype of bipolar cells (Agosto et al. 2018). Abnormal levels occur in plasma neuron-derived extracellular vesicles of early schizophrenia and other neurodevelopmental diseases (Goetzl et al. 2022).

Accession Number:Q7Z4N2
Protein Name:Transient receptor potential cation channel subfamily M member 1
Length:1603
Molecular Weight:182178.00
Species: [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate calcium(2+)

Cross database links:

RefSeq: NP_002411.3   
Entrez Gene ID: 4308   
Pfam: PF00520   
OMIM: 603576  gene
KEGG: hsa:4308   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005262 F:calcium channel activity
GO:0004872 F:receptor activity
GO:0006811 P:ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1).”  Hunter J.J.et.al.   9806836
[2] “Analysis of the DNA sequence and duplication history of human chromosome 15.”  Zody M.C.et.al.   16572171
[3] “Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.”  Duncan L.M.et.al.   9537257
[4] “Expression and up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells.”  Fang D.et.al.   11112417
[5] “Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.”  Xu X.-Z.S.et.al.   11535825
[6] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKDSNRCCCG QFTNQHIPPL PSATPSKNEE ESKQVETQPE KWSVAKHTQS YPTDSYGVLE 
61:	FQGGGYSNKA MYIRVSYDTK PDSLLHLMVK DWQLELPKLL ISVHGGLQNF EMQPKLKQVF 
121:	GKGLIKAAMT TGAWIFTGGV STGVISHVGD ALKDHSSKSR GRVCAIGIAP WGIVENKEDL 
181:	VGKDVTRVYQ TMSNPLSKLS VLNNSHTHFI LADNGTLGKY GAEVKLRRLL EKHISLQKIN 
241:	TRLGQGVPLV GLVVEGGPNV VSIVLEYLQE EPPIPVVICD GSGRASDILS FAHKYCEEGG 
301:	IINESLREQL LVTIQKTFNY NKAQSHQLFA IIMECMKKKE LVTVFRMGSE GQQDIEMAIL 
361:	TALLKGTNVS APDQLSLALA WNRVDIARSQ IFVFGPHWPP LGSLAPPTDS KATEKEKKPP 
421:	MATTKGGRGK GKGKKKGKVK EEVEEETDPR KIELLNWVNA LEQAMLDALV LDRVDFVKLL 
481:	IENGVNMQHF LTIPRLEELY NTRLGPPNTL HLLVRDVKKS NLPPDYHISL IDIGLVLEYL 
541:	MGGAYRCNYT RKNFRTLYNN LFGPKRPKAL KLLGMEDDEP PAKGKKKKKK KKEEEIDIDV 
601:	DDPAVSRFQY PFHELMVWAV LMKRQKMAVF LWQRGEESMA KALVACKLYK AMAHESSESD 
661:	LVDDISQDLD NNSKDFGQLA LELLDQSYKH DEQIAMKLLT YELKNWSNST CLKLAVAAKH 
721:	RDFIAHTCSQ MLLTDMWMGR LRMRKNPGLK VIMGILLPPT ILFLEFRTYD DFSYQTSKEN 
781:	EDGKEKEEEN TDANADAGSR KGDEENEHKK QRSIPIGTKI CEFYNAPIVK FWFYTISYLG 
841:	YLLLFNYVIL VRMDGWPSLQ EWIVISYIVS LALEKIREIL MSEPGKLSQK IKVWLQEYWN 
901:	ITDLVAISTF MIGAILRLQN QPYMGYGRVI YCVDIIFWYI RVLDIFGVNK YLGPYVMMIG 
961:	KMMIDMLYFV VIMLVVLMSF GVARQAILHP EEKPSWKLAR NIFYMPYWMI YGEVFADQID 
1021:	LYAMEINPPC GENLYDEEGK RLPPCIPGAW LTPALMACYL LVANILLVNL LIAVFNNTFF 
1081:	EVKSISNQVW KFQRYQLIMT FHDRPVLPPP MIILSHIYII IMRLSGRCRK KREGDQEERD 
1141:	RGLKLFLSDE ELKRLHEFEE QCVQEHFREK EDEQQSSSDE RIRVTSERVE NMSMRLEEIN 
1201:	ERETFMKTSL QTVDLRLAQL EELSNRMVNA LENLAGIDRS DLIQARSRAS SECEATYLLR 
1261:	QSSINSADGY SLYRYHFNGE ELLFEDTSLS TSPGTGVRKK TCSFRIKEEK DVKTHLVPEC 
1321:	QNSLHLSLGT STSATPDGSH LAVDDLKNAE ESKLGPDIGI SKEDDERQTD SKKEETISPS 
1381:	LNKTDVIHGQ DKSDVQNTQL TVETTNIEGT ISYPLEETKI TRYFPDETIN ACKTMKSRSF 
1441:	VYSRGRKLVG GVNQDVEYSS ITDQQLTTEW QCQVQKITRS HSTDIPYIVS EAAVQAEHKE 
1501:	QFADMQDEHH VAEAIPRIPR LSLTITDRNG MENLLSVKPD QTLGFPSLRS KSLHGHPRNV 
1561:	KSIQGKLDRS GHASSVSSLV IVSGMTAEEK KVKKEKASTE TEC