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1.A.4.5.3
MLSN1- and TRP-related MTR1 (TrpM5; LTRPC5) of 1165 aas and 6 TMSs.  Associated with the Beckman-Wiedemann Syndrum and causes a predisposition for neoplasia (Prawitt et al. 2000). Involved in taste to bitter, sweet and umami, but not absolutely required for these. Thus, TrpM5-dependent and TrpM5-independent pathways underlie bitter, sweet, and umami tastes (Damak et al. 2006). It plays a role in insulin secretion. It and phospholipase C-β2 colocalize in taste receptor cells of zebrafish (Yoshida et al. 2007). It is a voltage-modulated, Ca2+-activated, monovalent cation (Na+, K+, Cs+) channel (VCAM) that mediates transient membrane depolarization. It is blocked by extracellular acidification but activated by arachidonic acid (Prawitt et al. 2003). The cryoEM structure of TrpM5 in Zebrafish is known (See TC# 1.A.4.5.14).

Accession Number:Q9NZQ8
Protein Name:MTR1
Length:1165
Molecular Weight:131451.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), potassium(1+), caesium(1+)

Cross database links:

RefSeq: NP_055370.1   
Entrez Gene ID: 29850   
OMIM: 604600  gene
KEGG: hsa:29850   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0005244 F:voltage-gated ion channel activity
GO:0006811 P:ion transport

References (5)

[1] “Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.”  Prawitt D.et.al.   10607831
[2] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.”  Prawitt D.et.al.   14634208
[5] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MQDVQGPRPG SPGDAEDRRE LGLHRGEVNF GGSGKKRGKF VRVPSGVAPS VLFDLLLAEW 
61:	HLPAPNLVVS LVGEEQPFAM KSWLRDVLRK GLVKAAQSTG AWILTSALRV GLARHVGQAV 
121:	RDHSLASTST KVRVVAVGMA SLGRVLHRRI LEEAQEDFPV HYPEDDGGSQ GPLCSLDSNL 
181:	SHFILVEPGP PGKGDGLTEL RLRLEKHISE QRAGYGGTGS IEIPVLCLLV NGDPNTLERI 
241:	SRAVEQAAPW LILVGSGGIA DVLAALVNQP HLLVPKVAEK QFKEKFPSKH FSWEDIVRWT 
301:	KLLQNITSHQ HLLTVYDFEQ EGSEELDTVI LKALVKACKS HSQEPQDYLD ELKLAVAWDR 
361:	VDIAKSEIFN GDVEWKSCDL EEVMVDALVS NKPEFVRLFV DNGADVADFL TYGRLQELYR 
421:	SVSRKSLLFD LLQRKQEEAR LTLAGLGTQQ AREPPAGPPA FSLHEVSRVL KDFLQDACRG 
481:	FYQDGRPGDR RRAEKGPAKR PTGQKWLLDL NQKSENPWRD LFLWAVLQNR HEMATYFWAM 
541:	GQEGVAAALA ACKILKEMSH LETEAEAARA TREAKYERLA LDLFSECYSN SEARAFALLV 
601:	RRNRCWSKTT CLHLATEADA KAFFAHDGVQ AFLTRIWWGD MAAGTPILRL LGAFLCPALV 
661:	YTNLITFSEE APLRTGLEDL QDLDSLDTEK SPLYGLQSRV EELVEAPRAQ GDRGPRAVFL 
721:	LTRWRKFWGA PVTVFLGNVV MYFAFLFLFT YVLLVDFRPP PQGPSGPEVT LYFWVFTLVL 
781:	EEIRQGFFTD EDTHLVKKFT LYVGDNWNKC DMVAIFLFIV GVTCRMLPSA FEAGRTVLAM 
841:	DFMVFTLRLI HIFAIHKQLG PKIIVVERMM KDVFFFLFFL SVWLVAYGVT TQALLHPHDG 
901:	RLEWIFRRVL YRPYLQIFGQ IPLDEIDEAR VNCSTHPLLL EDSPSCPSLY ANWLVILLLV 
961:	TFLLVTNVLL MNLLIAMFSY TFQVVQGNAD MFWKFQRYNL IVEYHERPAL APPFILLSHL 
1021:	SLTLRRVFKK EAEHKREHLE RDLPDPLDQK VVTWETVQKE NFLSKMEKRR RDSEGEVLRK 
1081:	TAHRVDFIAK YLGGLREQEK RIKCLESQIN YCSVLVSSVA DVLAQGGGPR SSQHCGEGSQ 
1141:	LVAADHRGGL DGWEQPGAGQ PPSDT