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1.A.4.5.6
Transient receptor potential cation channel subfamily, member 3, TRPM3. It is subject to muscarinic receptor activation. An alternative ion permeation pathway in TRPM3 allows large inward currents upon hyperpolarization, independently of the central pore.  Four residues in S4 (W982, R985, D988 and G991) are determinants of the properties of the alternative ion permeation pathway (Held et al. 2018).  TRPM3 is a thermosensitive TRP channel, playing a central role in noxious heat sensation. Volitile anesthetics (VAs) inhibit TRPM3-mediated transmembrane currents. Chloroform, halothane, isoflurane and sevoflurane inhibited both the agonist-induced (pregnenolone sulfate, CIM0216) and heat-activated Ca2+ signals and transmembrane currents in a concentration dependent way in cells overexpressing recombinant TRPM3 (Kelemen et al. 2020). Among the tested VAs, halothane was the most potent blocker (IC50=0.52+/-0.05 mM). VAs exerted their effects on native TRPM3 channels expressed in sensory neurons of the dorsal root ganglia. While volatile anesthetics activate certain sensory neurons independently of TRPM3, they strongly and reversibly inhibit the agonist-induced TRPM3 activity (Kelemen et al. 2020).

Accession Number:Q9HCF6
Protein Name:Transient receptor potential cation channel subfamily M member 3
Length:1732
Molecular Weight:197571.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 80036   
Pfam: PF00520   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity

References (5)

[1] “Molecular and functional characterization of the melastatin-related cation channel TRPM3.”  Grimm C.et.al.   12672799
[2] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[3] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[4] “Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).”  Lee N.et.al.   12672827
[5] “Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10997877

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 
61:	QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 
121:	QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 
181:	KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 
241:	KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 
301:	GKYGAEVKLR RQLEKHISLQ KINTRCLPFF SLDSRLFYSF WGSCQLDSVG IGQGVPVVAL 
361:	IVEGGPNVIS IVLEYLRDTP PVPVVVCDGS GRASDILAFG HKYSEEGGLI NESLRDQLLV 
421:	TIQKTFTYTR TQAQHLFIIL MECMKKKELI TVFRMGSEGH QDIDLAILTA LLKGANASAP 
481:	DQLSLALAWN RVDIARSQIF IYGQQWPVGS LEQAMLDALV LDRVDFVKLL IENGVSMHRF 
541:	LTISRLEELY NTRHGPSNTL YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT 
601:	RKRFRTLYHN LFGPKRPKAL KLLGMEDDIP LRRGRKTTKK REEEVDIDLD DPEINHFPFP 
661:	FHELMVWAVL MKRQKMALFF WQHGEEAMAK ALVACKLCKA MAHEASENDM VDDISQELNH 
721:	NSRDFGQLAV ELLDQSYKQD EQLAMKLLTY ELKNWSNATC LQLAVAAKHR DFIAHTCSQM 
781:	LLTDMWMGRL RMRKNSGLKV ILGILLPPSI LSLEFKNKDD MPYMSQAQEI HLQEKEAEEP 
841:	EKPTKEKEEE DMELTAMLGR NNGESSRKKD EEEVQSKHRL IPLGRKIYEF YNAPIVKFWF 
901:	YTLAYIGYLM LFNYIVLVKM ERWPSTQEWI VISYIFTLGI EKMREILMSE PGKLLQKVKV 
961:	WLQEYWNVTD LIAILLFSVG MILRLQDQPF RSDGRVIYCV NIIYWYIRLL DIFGVNKYLG 
1021:	PYVMMIGKMM IDMMYFVIIM LVVLMSFGVA RQAILFPNEE PSWKLAKNIF YMPYWMIYGE 
1081:	VFADQIDPPC GQNETREDGK IIQLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT 
1141:	FFEVKSISNQ VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MIFQHLCCRW RKHESDPDER 
1201:	DYGLKLFITD DELKKVHDFE EQCIEEYFRE KDDRFNSSND ERIRVTSERV ENMSMRLEEV 
1261:	NEREHSMKAS LQTVDIRLAQ LEDLIGRMAT ALERLTGLER AESNKIRSRT SSDCTDAAYI 
1321:	VRQSSFNSQE GNTFKLQESI DPAGEETMSP TSPTLMPRMR SHSFYSVNMK DKGGIEKLES 
1381:	IFKERSLSLH RATSSHSVAK EPKAPAAPAN TLAIVPDSRR PSSCIDIYVS AMDELHCDID 
1441:	PLDNSVNILG LGEPSFSTPV PSTAPSSSAY ATLAPTDRPP SRSIDFEDIT SMDTRSFSSD 
1501:	YTHLPECQNP WDSEPPMYHT IERSKSSRYL ATTPFLLEEA PIVKSHSFMF SPSRSYYANF 
1561:	GVPVKTAEYT SITDCIDTRC VNAPQAIADR AAFPGGLGDK VEDLTCCHPE REAELSHPSS 
1621:	DSEENEAKGR RATIAISSQE GDNSERTLSN NITVPKIERA NSYSAEEPSA PYAHTRKSFS 
1681:	ISDKLDRQRN TASLRNPFQR SKSSKPEGRG DSLSMRRLSR TSAFQSFESK HN