1.A.4.6.5
Thermosensitive TPR channel TRPA1 (TrpA-1) of 1211 aas. Detects a temperature drop promoting increased longevity. This requires TPRA1-mediated Ca2+ influx and activation of protein kinase C. Human TRPA1 (TC# 1.A.4.6.3) can functionally substitute for worm TRPA-1 in promoting longevity (Xiao et al. 2013). Also mediates touch sensation.
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| Accession Number: | Q18297 |
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| Protein Name: | Transient receptor potential cation channel subfamily A member 1 homolog |
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| Length: | 1211 |
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| Molecular Weight: | 138450.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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1: MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL RSIIHQSARE
61: GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV KLLLSKNALP NTKNREGDTP
121: LHIASKYIYG YSDICSIIDE DQADSARKYN TATKKIINAL VSENAEIDPV NKYQLTPLHY
181: AAMKSNFSAL HALIKLKADV DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL
241: NTVFHIVALR GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM
301: EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH VAAQMNQLEV
361: VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA KKANLTITDK DERTPVFIGA
421: KFNALSSVEY ILDHLRKKNK ETERSALKSP TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI
481: VASNGYLEMM QLLQKHGASI TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM
541: GNSALHLAAR SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI
601: ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND HKDVARAFLE
661: TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE LASFVMDNCI EKSKEETDST
721: QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP
781: LKLMADAEKL HLLNHPLSKA LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN
841: VWNEESYYDS EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN
901: WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL FMIRKMPRFG
961: IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE FSTIFMSPLK TTVMMIGEFE
1021: FTGIFHGDET THAEKMFGPA HTAVACALFF FFCIIMTILL MNLLVGLAVD DIKGVQEKAE
1081: LKRLAMQVDL VLQIEASLHF FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS
1141: VSTDPEIDEM YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL
1201: NINIELEEKD N