1.A.4.6.7
TRP ankyrin 1 (TRPA1 of 1188 aas). It is a homotetrameric, non-selective, cation channel with multiple ankyrin repeats at the N-terminus. The systems from insects to birds are heat activatable, and this activation is dependent on an extracellular Ca2+ binding site near the vestibule surface. Neutralization of acidic amino acids by
extracellular Ca2+ seems to be important for heat-evoked activation (Kurganov et al. 2017).
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| Accession Number: | G1KQ06 |
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| Protein Name: | Uncharacterized protein |
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| Length: | 1188 |
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| Molecular Weight: | 133994.00 |
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| Species: | Anolis carolinensis (Green anole) [28377] |
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| Number of TMSs: | 7 |
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| Substrate |
cation |
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1: MMVISFPLVL PQEPLESREA SFPSLPFPRR SFSSPPPPQA DAGSLFGCGG APGREGGRQG
61: RKRGLSMASP LTRCLLLVPP AGSQAARSPA MKRSLRKWLQ SGEKKARTSY EGVVCEADAA
121: SLASQDVFKV ISDGSTSRLR SFIKKNREGL KKLDDLNATP LHHAAGQGQL ELMQMIIDSS
181: SEALNVTDTS GNTPLHWATK KNQIESVKLL LSRGANPNIL NSNMMAPLHL AVQSLRNELV
241: KIFVEHTTTD INLEGENGNT PITIACYKDN SEALKLLIEN GAKICKGNSM GWMPVHAAAF
301: SGAKACMEIL IKRGEETGYS PENHINFTNN GKCTALHLAV QSGDLEMIKM CIEYGAQIDL
361: KQNDKCTALH FAATQGATEI LKLMMSSYTG DEPIIDALDE NKETLLHRVA LFDHYELAEY
421: LITMGAKIDS VDIEGRTPLL LATSCASWKI VNLLLSKGAN VELKDHLGRN FLHLTVLHPG
481: GLKHLNEQFL KMKHIKELVT DEDNDGCTPL HYACRQGVPL SVNSLLELDV SIYSKSRDKK
541: SPLHFAASYG RINTCQRLLR DMVDTRLLNE GDKKGMTPLH LAAQNGHEKV VQFLLRKGAL
601: FLCDYKGWTA LHHAAFGGYT RTMQIILNTN VKCTDKVDEE GNTALHLAAK EGHPKAVRLL
661: LDDNAKILLN KSDASFLHEA IHNGRKEVVN ATILHKRWEE SMTTFSHYSS ANKCAILEMV
721: EYLPECLKLV LDNCMIESCE EKTCRDFHIE YNFRYLQCPL KLTKQFKEGD EIMYEPLHNL
781: NAMVRHNRVE LLSHPVCTEY LLMKWMAYGF KAHLMNLAVY SLGLIPLTLL IVHIERPEPP
841: YNATVKSGPF GKKNSYFIKV CMCLVFIMSV FGICKEIVQL FQQKLRYLLD YSNLLDWIIY
901: TTSITFVSSL FINLPANLQW ECGATAIFLS WMNFLLYLQR FENFGIYVVM FWEILRTLIR
961: IAIVFFFLML AFGLSFHVLL GSQEAYGTPY LSVMQTFAMM LGDINYHDAF LEPMLTNKLP
1021: YPLLSYIILI VFTLLIPILL MNLLIGLAVG DIAEVQKFAV LKRIAMQVNL HTNLEKKLPY
1081: WFLSRVDQES ITVYPNRPRY CGFMSVFQYC FGCDDRASNV PSADTSLELE VLKQKYRLKD
1141: IATLMEKQHD LLKLVVQKME IISEAEDEDT NDLFQHKFRK QQLEHKNN