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1.A.4.7.1
The mechanically gated hearing and balance ion channel in sensory hair cells of the vertebrate inner ear, NompC (Sidi et al., 2003)

Accession Number:Q7T1G6
Protein Name:Ion channel NompC
Length:1614
Molecular Weight:175800.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio). [7955]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate calcium(2+)

Cross database links:

RefSeq: NP_899192.1   
Entrez Gene ID: 368273   
Pfam: PF00023    PF00520   
KEGG: dre:368273   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport
GO:0050910 P:detection of mechanical stimulus involved i...
GO:0055085 P:transmembrane transport

References (1)

[1] “NompC TRP channel required for vertebrate sensory hair cell mechanotransduction.”  Sidi S.et.al.   12805553

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MSESSCVSGA PQRLVPLALR GEWMALEQKI KTLERGDPDI LQCDEESGMS LLMLAVRESR 
61:	LSVLDRLLEL GANPSDKTKD GRSALHIAAA HSKDEIVKLL VRKTDPNSPA GPNDQLPLHY 
121:	AASRSTGGLA VVQTLLKFSS KDARLTPDKN GCLPLLLAAE AGNVGIVREL LSSQSEPQIR 
181:	AAKTANGDTA LHICCRRRDV EMAKILVEFG ANPDSQNDEG QTPLHIAAHE GDENMLKFLY 
241:	LCKANANISD KMDRSPLHIA AERGHTNVVE ILTEKFRSCV LARTKDGNTL LHIASQCGHP 
301:	TTALSFLRKG VPLHMPNKSG AVCLHAAAKR GHTAVVKALL QKGAHVDAAA RDGQTALHIA 
361:	VENCRPQVVQ MLLGFGAHVQ LRGGKAQETP LHISARVKEG ERAAEMLLKS GAEVNAEQEN 
421:	GETALHVAAR HGSLQMIRAL IQEGGDPRWR SRVGESPLHV AVRHCHAHVV QEILTFLTNE 
481:	KSRRDAELCV CEGNQDGETA LHLAAELRTD ALHQPEEDIT IIQILMEHQA DITAVTRQTG 
541:	ETPLHYSARV GNTAVLQEML RNVPTNQIQT AINKHSKNGW SPLLLAADQG HTEVVKILLQ 
601:	NNARVDVFDE EGKAAIHLAA QRGHQDIVDV LLSQKAFVNA KTKQGLTPLH LSAQNGSARL 
661:	VRLLVENHQA SVDALSLRKQ TPLHLAAMSG QLDVCSSLLN LRADITATDS RGQTPLHLAA 
721:	ESDHSEVVKL FLRLRPELST LANEDGSTCT HIAAAKGSVS VIRELLMFNQ GGVGTLNHKA 
781:	HGLCPLHLAA AGGHAEVVKV LLEAGASVTE EDAEGMTAVH LAAKHGHTHI LEVLRGSVPL 
841:	KIQSSKTGFT ALHVAASFGQ MNFVREILTK VPATIRSEFP TISGKDDIKR QQPLAESGFT 
901:	PLHLASQSGH ESVVRLLLNC PGVQADAETN IQGSSPLHLA AQSGHTAVVG LLLSRSSSLL 
961:	HQADRRGRSA LHLAAAHGHV DMVRVLLGQG AEINHTDMSG WTALHYAAEA GCLEVLLFLV 
1021:	ESGASACAEC HGGRTPLQYA AQQNHESAVI FLLRREKNTL RLLDDKKFIF NLMVCGRMND 
1081:	NLSLEELVLH TSAPLDTAVR LSRALTLCAL REKERSVDLQ AAAHHCELMA SDLLSLSASA 
1141:	GGQGAGAGPI LRALDHRGLS VLDCLIEGRQ KGVVSQPAVQ TYLTEVWCGG LQWDSWKILL 
1201:	LFCCLLLCPP LWLLLALPLT HSFNTIPIVK FMSHLVSHIF LLTLFILTIV YPPVSPLSQA 
1261:	RLMPSWSECL LLIWLCGMLV SELTFPGERT GLAWIRLLLL GFSAAALLCH LLAVFTQWWP 
1321:	PTHLHCLFAR NVLLAVAMTL GFIQLLEFLT FHHLFGPWAI IIRDLIKDLC RFAVILMLFH 
1381:	TAFTLSLTAL CQPLYPQEQH NTTTEVTVPG PLNMSVLLFF ALFGLTEPDK IPDVDRSPPA 
1441:	TAVLAKMVFG VYLVVTFIVL INLLIAMMSD TYQRIQAQSD TEWKFGRAVL IRDMSRKSGI 
1501:	PSPFNLFTNL FYSVKVVCKR AGKMCSSESR DVMNEDEDAE GLSESRSLDL LSQASVSGIR 
1561:	GNKRTQILPE GGQISLAHSG GHVRVENVAD WPSVVQQFLS QRRQRDRSTA ERDE