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1.A.4.7.2
The sensory ion channel in tactile bristles of insects, NompC.  The atomic structure of Drosophila NOMPC has been determined by single-particle electron cryo-microscopy. Structural analyses suggested that the ankyrin repeat domain (29 repeats) of NOMPC resembles a helical spring, suggesting its role of linking mechanical displacement of the cytoskeleton to the opening of the channel (Jin et al. 2017). Compression of the ankyrin chains imparts a rotational torque on the TRP domain, which may result in channel opening (Argudo et al. 2019).

Accession Number:Q9VMR4
Protein Name:NompC
Length:1619
Molecular Weight:176844.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cation

Cross database links:

RefSeq: NP_523483.1   
Entrez Gene ID: 33768   
Pfam: PF00023    PF00520   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0003848 F:2-amino-4-hydroxy-6-hydroxymethyldihydropte...
GO:0030506 F:ankyrin binding
GO:0008381 F:mechanically-gated ion channel activity
GO:0050910 P:detection of mechanical stimulus involved i...
GO:0006811 P:ion transport
GO:0007638 P:mechanosensory behavior
GO:0055085 P:transmembrane transport

References (2)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSQPRGGRGG GRGGGVGRKT PSSLTGPPDE SATPSERATP ASKADSDPKD DSSSNGDKKD 
61:	MDLFPAPKPP SAGASIRDTA NKVLGLAMKS EWTPIEAELK KLEKYVANVG EDGNHIPLAG 
121:	VHDMNTGMTP LMYATKDNKT AIMDRMIELG ADVGARNNDN YNVLHIAAMY SREDVVKLLL 
181:	TKRGVDPFST GGSRSQTAVH LVSSRQTGTA TNILRALLAA AGKDIRLKAD GRGKIPLLLA 
241:	VESGNQSMCR ELLAAQTAEQ LKATTANGDT ALHLAARRRD VDMVRILVDY GTNVDTQNGE 
301:	GQTPLHIAAA EGDEALLKYF YGVRASASIA DNQDRTPMHL AAENGHAHVI EILADKFKAS 
361:	IFERTKDGST LMHIASLNGH AECATMLFKK GVYLHMPNKD GARSIHTAAA YGHTGIINTL 
421:	LQKGEKVDVT TNDNYTALHI AVESAKPAVV ETLLGFGADV HVRGGKLRET PLHIAARVKD 
481:	GDRCALMLLK SGASPNLTTD DCLTPVHVAA RHGNLATLMQ LLEDEGDPLY KSNTGETPLH 
541:	MACRACHPDI VRHLIETVKE KHGPDKATTY INSVNEDGAT ALHYTCQITK EEVKIPESDK 
601:	QIVRMLLENG ADVTLQTKTA LETAFHYCAV AGNNDVLMEM ISHMNPTDIQ KAMNRQSSVG 
661:	WTPLLIACHR GHMELVNNLL ANHARVDVFD TEGRSALHLA AERGYLHVCD ALLTNKAFIN 
721:	SKSRVGRTAL HLAAMNGFTH LVKFLIKDHN AVIDILTLRK QTPLHLAAAS GQMEVCQLLL 
781:	ELGANIDATD DLGQKPIHVA AQNNYSEVAK LFLQQHPSLV NATSKDGNTC AHIAAMQGSV 
841:	KVIEELMKFD RSGVISARNK LTDATPLQLA AEGGHADVVK ALVRAGASCT EENKAGFTAV 
901:	HLAAQNGHGQ VLDVLKSTNS LRINSKKLGL TPLHVAAYYG QADTVRELLT SVPATVKSET 
961:	PTGQSLFGDL GTESGMTPLH LAAFSGNENV VRLLLNSAGV QVDAATIENG YNPLHLACFG 
1021:	GHMSVVGLLL SRSAELLQSQ DRNGRTGLHI AAMHGHIQMV EILLGQGAEI NATDRNGWTP 
1081:	LHCAAKAGHL EVVKLLCEAG ASPKSETNYG CAAIWFAASE GHNEVLRYLM NKEHDTYGLM 
1141:	EDKRFVYNLM VVSKNHNNKP IQEFVLVSPA PVDTAAKLSN IYIVLSTKEK ERAKDLVAAG 
1201:	KQCEAMATEL LALAAGSDSA GKILQATDKR NVEFLDVLIE NEQKEVIAHT VVQRYLQELW 
1261:	HGSLTWASWK ILLLLVAFIV CPPVWIGFTF PMGHKFNKVP IIKFMSYLTS HIYLMIHLSI 
1321:	VGITPIYPVL RLSLVPYWYE VGLLIWLSGL LLFELTNPSD KSGLGSIKVL VLLLGMAGVG 
1381:	VHVSAFLFVS KEYWPTLVYC RNQCFALAFL LACVQILDFL SFHHLFGPWA IIIGDLLKDL 
1441:	ARFLAVLAIF VFGFSMHIVA LNQSFANFSP EDLRSFEKKN RNRGYFSDVR MHPINSFELL 
1501:	FFAVFGQTTT EQTQVDKIKN VATPTQPYWV EYLFKIVFGI YMLVSVVVLI NLLIAMMSDT 
1561:	YQRIQVVLLN ALLSNSTLFI NSYFNHKYIN FILHCVLIIL YFSIRSKFTY EDDLYFLDI