1.A.4.7.3
The pore forming subunit, Trp-4, a mechanosensitive cation/Ca2+ channel. Present in ciliated mechanosensitive neurons; Activation and latency occur in the microsecond range. trp-4 mutations alter ion selectivity (Kang et al., 2010; Xiao and Xu 2009).
|
| Accession Number: | Q9GRV5 |
|---|
| Protein Name: | Protein Y71A12B.4, partially confirmed by transcript evidence |
|---|
| Length: | 1924 |
|---|
| Molecular Weight: | 212903.00 |
|---|
| Species: | Caenorhabditis elegans [6239] |
|---|
| Number of TMSs: | 9 |
|---|
| Substrate |
calcium(2+) |
|---|
| Entrez Gene ID: |
190574
|
|---|
| Pfam: |
PF00023
PF00520
|
|---|
| KEGG: |
cel:Y71A12B.4
|
|---|
|
|
[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortium et.al. 9851916
|
1: MDSPRGGILG RALREASQST RQENDVDMDQ VPVRQMNRDY GGSRRTQMNP HTSQPGPSHV
61: SIVNVPERGG PTSSTSTTHE TEHTAHRTES GRFIRRRRQS REVTTTTTRP YDPAPPTQTR
121: TSSGSTVNGW GENRPKSADE EIKRRRRSGG GILSRGLREM NKMVEELEQA SEEPSTRKGI
181: LGTALKDMEG TTYQKIYRKR EETPKRSRSF DDQEMSNRVG MIEHLLRDKD PLELQQLGLT
241: DLLTTDTIPT DRPPLRRSST HLQIGKNSRI IFVPKQPSRD SVTPPDRLLG KPLFRESLTS
301: HASSHEEMSS EDLAMADPQT KILYFAKRDE WANVESEIET IKRSDFSMAD NHGFTAFLLA
361: VKAGKDQIVD KMIRKGARVD YSTKDGRNAT HIAAMYSGVE TLELILKRYS ELLRKGAGPK
421: KQLAIHVACE RKSKKAFPIV KRILEDTDQR MAEDGDGSLP IHLAFKFGNV NIVELLLSGP
481: SDEQTRKADG NGDTLLHLAA RSGNIEAVRT AIAAGCDNAN VQNRVGRTPL HEVAEVGDQN
541: MLKIMFKLRA DANIHDKEDK TPVHVAAERG DTSMVESLID KFGGSIRART RDGSTLLHIA
601: ACSGHTSTAL AFLKRGVPLF MPNKKGALGL HSAAAAGFND VVKMLIARGT NVDVRTRDNY
661: TALHVAVQSG KASVVETLLG SGADIHVKGG ELGQTALHIA ASLNGAESRD CAMMLLKSGG
721: QPDVAQMDGE TCLHIAARSG NKDIMRLLLD ENADSKISSK IGETPLQVAA KSCNFEAASM
781: ILKHLSEVLT QEQLKEHVNH RTNDGFTALH YAAEIEQRQL HFPGEDAKLV NLLIDYGGMV
841: EMPSLNANET AMHMAARSGN QAVLLAMVNK IGAGAVQIVQ NKQSKNGWSP LLEACARGHS
901: GVANILLKHH ARIDVFDEMG RTALHLAAFN GHLSLVHLLL QHKAFVNSKS KTGEAPLHLA
961: AQHGHVKVVN VLVQDHGAAL EAITLDNQTA LHFAAKFGQL AVSQTLLALG ANPNARDDKG
1021: QTPLHLAAEN DFPDVVKLFL KMRNNNRSVL TAIDHNGFTC AHIAAMKGSL AVVRELMMID
1081: KPMVIQAKTK TLEATTLHMA AAGGHANIVK ILLENGANAE DENSHGMTAL HLGAKNGFIS
1141: ILEAFDKILW KRCSRKTGLN ALHIAAFYGN SDFVNEMLKH VQATVRSEPP IYNHHVNKEF
1201: STEYGFTPLH LAAQSGHDSL VRMLLNQGVQ VDATSTTMNV IPLHLAAQQG HIAVVGMLLS
1261: RSTQQQHAKD WRGRTPLHLA AQNGHYEMVS LLIAQGSNIN VMDQNGWTGL HFATRAGHLS
1321: VVKLFIDSSA DPLAETKEGK VPLCFAAAHN HIECLRFLLK QKHDTHQLME DRKFIFDLMV
1381: CGKTNDNEPL QEFILQSPAP IETAVKLSAL YRDMSEKEKE RAKDLLNVAV FSENMAVELL
1441: GITATEYNAA LLLKAKDNRG RPLLDVLIEN EQKEVVSYAS VQRYLTEVWT ARVDWSFGKF
1501: VAFSLFVLIC PPAWFYFSLP LDSRIGRAPI IKFVCHIVSH VYFTILLTIV VLNITHKMYE
1561: VTSVVPNPVE WLLLLWLSGN LVSELSTVGG GSGLGIVKVL ILVLSAMAIA VHVLAFLLPA
1621: VFLTHLDNDE KLHFARTMLY LKNQLFAFAL LFAFVEYLDF LTVHHLFGPW AIIIRDLMYD
1681: LARFLVILML FVAGFTLHVT SIFQPAYQPV DEDSAELMRL ASPSQTLEML FFSLFGLVEP
1741: DSMPPLHLVP DFAKIILKLL FGIYMMVTLI VLINLLIAMM SDTYQRIQAQ SDKEWKFGRA
1801: ILIRQMNKKS ATPSPINMLT KLIIVLRVAW RNRLRCMTRK AQDDLRFEEN IDAFSMGGGQ
1861: QGRQSPTNEG REGQQELGNS ADWNIETVID WRKIVSMYYQ ANGKLTDGRT KEDVDLAMAV
1921: PTSF