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1.A.5.3.7
Mucolipin-1 or CUP-5 of 611 aas and 6 TMSs in a 1 + 5 TMS arrangement. This C. elegans ortholog of the human protein is required for lysosome biogenesis. Mutations in cup-5 result in the accumulation of large vacuoles in several cells, in increased cell death, and in embryonic lethality (Treusch et al. 2004).

Accession Number:Q9BJ56
Protein Name:CUP-5
Length:611
Molecular Weight:69846.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRRSTTDRS DFNDNASNAS SNASRRPTIN FQEIMEDLPH HERETGERLR RHLQFFFMNP 
61:	MEKWKVRHQL PYKLVLQVLK IVFVTMQLIL FAEMRMSHVD FLEDTTTVMR HRFLKEWNDD 
121:	RDALQYPPAE GRYSVYDDQG LSEHLSFLIN SYYSIRNDSF ASFSYDVVSH PSGNLGAQIS 
181:	FESIPPIEVL IDRISNVTVN NNTYNFDIRE VKDTKRLNLT ETEVFQIGQS DDAVRDILAT 
241:	RGITFLPEDA LKISTVQFKF RLRTIHYSPT AGDQKPECYK ISVSIKFDNS RHTGQVHVTL 
301:	STVVSYVNVC NGRIIKGQVS GVGWSFDTLL IGGTDIFVLI LCILSLILCC RALIKAHLLQ 
361:	IKTSDYFENV LKNKITVTDQ LDFLNLWYVM IVVNDALIII GTVAKISIEF QDFDNSLFTL 
421:	TSIFLGMGAL LVYVGVLRYF GFFSQYNILM LTLKRSAPNI MRFMTCAIVL YAGFLIAGWV 
481:	IIGPYSMKFR TLAESSEALF SLLNGDDMFA TFYTINDSNT VIKVFGTVYI YLFVSLFIYV 
541:	VLSLFIAIIM DAYEVVKDRY SDGLRAIEKR GCLRDFVESN PPPSELGSPT TRSAYAPSNL 
601:	LNLGRGWQRL E