1.A.50.2.1
Sarcolipin (SLN) anion pore-forming protein of 31 aas and 1 TMS, with selectivity for Cl^- and H₂PO₄^-. Oligomeric interactions of sarcolipin and the Ca-ATPase have been documented (Autry et al., 2011).  Sarcolipin, but not phospholamban, promotes uncoupling of the SERCA pump (3.A.3.2.7; Sahoo et al. 2013).  SNL forms pentameric pores that can transport water, H⁺, Na⁺, Ca²⁺ and Cl^-.  Leu21 serves as the gate (Cao et al. 2015).   In the channel, water molecules near the Leu21 pore demonstrated a clear hydrated-dehydrated transition (Cao et al. 2016). Small ankyrin 1 (sAnk1; TC#8.A.28.1.2) and SLN interact with each other in their transmembrane domains to regulate SERCA (TC# 3.A.3.2.7) (Desmond et al. 2017). The TM voltage has a positive effect on the permeability of water molecules and ions (Cao et al. 2020). The conserved C-terminus is an essential element required for the dynamic control of SLN regulatory function (Aguayo-Ortiz et al. 2020).