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1.A.50.4.1
DWORF of 34 aas and 1 TMS (Nelson et al. 2016).  Counteracts the inhibitory effects of single transmembrane peptides, phospholamban (TC# 1.A.50.1), sarcolipin (1.A.50.2) and myoregulin (1.A.50.3), on SERCA (TC# 3.A.3.2). DWORF also activates SERCA in the absence of PLM (Li et al. 2021). Homology with the inhibitory peptides has been established for these peptides, all of which have about the same size with a single C-terminal TMS (D. Tyler & M. Saier, unpublished results). 

Accession Number:P0DN84
Protein Name:Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
Length:35
Molecular Weight:3836.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Sarcoplasmic reticulum membrane1 / Single-pass membrane protein2
Substrate Ca2+

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FASTA formatted sequence
1:	MAEKAGSTFS HLLVPILLLI GWIVGCIIMI YVVFS