DWORF of 34 aas and 1 TMS (Nelson et al. 2016). Counteracts the inhibitory effects of single transmembrane peptides, phospholamban (TC# 1.A.50.1), sarcolipin (1.A.50.2) and myoregulin (1.A.50.3), on SERCA (TC# 3.A.3.2). DWORF also activates SERCA in the absence of PLM (Li et al. 2021). Homology with the inhibitory peptides has been established for these peptides, all of which have about the same size with a single C-terminal TMS (D. Tyler & M. Saier, unpublished results).
|Protein Name:||Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF|
|Species:||Homo sapiens (Human)  |
|Number of TMSs:||1|
|Location1 / Topology2 / Orientation3:
Sarcoplasmic reticulum membrane1 / Single-pass membrane protein2
1: MAEKAGSTFS HLLVPILLLI GWIVGCIIMI YVVFS