TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.50.4.1
DWORF of 34 aas and 1 TMS (Nelson et al. 2016).  Counteracts the inhibitory effects of single transmembrane peptides, phospholamban (TC# 1.A.50.1), sarcolipin (1.A.50.2) and myoregulin (1.A.50.3), on SERCA (TC# 3.A.3.2).  Homology with the inhibitory peptides has not been established although all of these peptides have about the same size with a single C-terminal TMS. 

Accession Number:P0DN84
Protein Name:Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
Length:35
Molecular Weight:3836.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Sarcoplasmic reticulum membrane1 / Single-pass membrane protein2
Substrate Ca2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAEKAGSTFS HLLVPILLLI GWIVGCIIMI YVVFS