Neuronatin, NNAT, of 81 aas and 1 TMS. NNAT, in the endoplasmic reticulum, is involved in metabolic regulation. It shares sequence similarity with sarcolipin (SLN; TC# 1.A.50.2.1), which negatively regulates the SERCA that maintains energy homeostasis in muscles. Braun et al. 2021 showed that NNAT could uncouple the Ca2+ transport activity of SERCA from ATP hydrolysis like SLN. NNAT reduced Ca2+ uptake without altering SERCA activity, ultimately lowering the apparent coupling ratio of SERCA. This effect of NNAT was reversed by the adenylyl cyclase activator forskolin. Soleus muscles from high fat diet-fed mice showed downregulation in NNAT content compared with chow-fed mice, whereas an upregulation in NNAT content was observed in fast-twitch muscles from high fat diet- versus chow-fed mice. Therefore, NNAT is a SERCA uncoupler and may function in adaptive thermogenesis (Braun et al. 2021).
|Species:||Homo sapiens (Human)  |
|Number of TMSs:||1|
1: MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL
61: AYTVSRTGRQ VLGERRQRAP N