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1.A.64.4.4 CKLF-like MARVEL transmembrane domain-containing protein 4, CMTM4, of 234 aas and 4 TMSs. It acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (Mezzadra et al. 2017).
Accession Number:	Q8IZR5
Protein Name:	CKLF-like MARVEL transmembrane domain-containing protein 4
Length:	234
Molecular Weight:	25828.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	4
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

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FASTA formatted sequence

1:	MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL RGALGRLKVA 
61:	QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV LLIMFSLNLH MRIPQINWNL 
121:	TDLVNTGLSA FLFFIASIVL AALNHRAGAE IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR 
181:	QQSTNDYIRA RTESRDVDSR PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA

1.A.64.4.4
CKLF-like MARVEL transmembrane domain-containing protein 4, CMTM4, of 234 aas and 4 TMSs. It acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (Mezzadra et al. 2017).

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1.A.64.4.4CKLF-like MARVEL transmembrane domain-containing protein 4, CMTM4, of 234 aas and 4 TMSs. It acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (Mezzadra et al. 2017).

Cross database links:

External Searches:

Analyze:

1.A.64.4.4
CKLF-like MARVEL transmembrane domain-containing protein 4, CMTM4, of 234 aas and 4 TMSs. It acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (Mezzadra et al. 2017).