TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.97.1.1









The E5 viroporin protein of 83 aas and 3 TMSs (Wetherill et al. 2012). It forms hexameric channels with TMS2 lining the pore, creating a water column through which ions and small molecules, including H+, can pass fairly non-specifically (Mahato and Fischer 2016). A "snapshot" structure of the putative open pore of the protein bundle suggested the proposed low channel selectivity (Mahato and Fischer 2016). The protein is involved in signalling and protein trafficking. Its gene may be an oncogene (Scott and Griffin 2015).The protein also interacts with the fourth TMS of the 16 kDa c subunit of the human vacuolar H+-ATPase (Mahato and Fischer 2018).

Viruses
Shotokuvirae, Cossaviricota
E5 protein of high-risk human papillomavirus (cervical cancer-causing) type 16 (HPV16)
1.A.97.1.2









Human papillomavirus type 82 E5 protein of 84 aas and 3 TMSs.

Viruses
Shotokuvirae, Cossaviricota
E5 of human papillomavirus type 82
1.A.97.1.3









Human papillomavirus type 39 E5 protein of 72 aas and 2 TMSs.

Viruses
Shotokuvirae, Cossaviricota
E5 protein of human papillomavirus type 39
1.A.97.1.4









Common chimpanzee papillomavirus 1 E5 protein of 94 aas and 3 TMSs

Viruses
Shotokuvirae, Cossaviricota
E5 protein of the common chimpanzee papillomavirus 1
1.A.97.1.5









Human papillomavirus type 6 E5a protein of 91 aas and 3 TMSs.

Viruses
Shotokuvirae, Cossaviricota
E5a protein of human papillomavirus type 6