1.B.1.1.20
Outer membrane porin 1, OmpPst1 or Omp-Pst1. Transports beta lactams with decreased efficiency in the order of ertapenem > cefepime > cefoxitin (Tran et al. 2010). 93% identical in sequence to 1.B.1.1.11. Voltage-gating of this porin and porin 2 (TC# 1.B.1.1.24) from the same organism have been analyzed (Song et al. 2015). Facing channels are open in any two adjacent porin structures, suggesting that dimers and trimers not only promote cell-to-cell contact but also contribute to intercellular communication (El-Khatib et al. 2018).
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| Accession Number: | J9VK71 |
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| Protein Name: | Porin |
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| Length: | 371 |
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| Molecular Weight: | 40894.00 |
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| Species: | Providencia stuartii [588] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cefepime, cefoxitin, ertapenem |
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1: MMKRNILAMV IPALLAAGAA NAAEVYNKDG NKLDVYGKVD VRHYFADADK GKKSEDGDDS
61: RVRLGVKGDT QITDQLTGFG RFEWETKTNK AENEGENKNR LAYAGLKFAD FGSIDYGRNY
121: GVVYDTNAWT DVFPLWGADT MAQSDNFMTS RNRNLLTYRN NNAFGYVDGL SFALQYQGKN
181: GDNNKSSAGE AAKDNGDGYG FSAAYDLGWG VSLGGGYSNS SRTPNQQHNT TAGGQKAQAW
241: NVGGKFDANN VYLAAMYGQT LNTTRYGSKD SIANKTENVE LVAQYLFDFG LKPSIGYNQS
301: KGKDLGRAYN GKTYNNQDLV KYISVGSYYY FNKNMSAVVD YKINLLKDND FTRENGINTD
361: NVLGLGLVYQ F