1.B.1.4.3
Porin of 38 KDa,Omp38 in Burkholderia pseudomallei, the causative agent of
melioidosis, an infectious disease of animals and humans. MDR can be due to mutations in Omp38. Ion current
blockages of reconstituted Omp38 by seven antimicrobial agents occurred in a concentration-dependent
manner with the translocation on-rate following the order:
norfloxacin>ertapenem>ceftazidime>cefepime>imipenem>meropenem>penicillin
G (Suginta et al. 2011). Also allows transport of neutral sugars and numerous antimicrobial agents including cephalosporin and carbapenem (Aunkham et al. 2014).
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| Accession Number: | Q7WZL2 |
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| Protein Name: | Outer membrane porin |
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| Length: | 374 |
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| Molecular Weight: | 39132.00 |
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| Species: | Burkholderia pseudomallei [28450] |
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| Number of TMSs: | 1 |
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| Substrate |
norfloxacin, cefepime, imipenem, ceftazidime, meropenem, ertapenem |
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1: MNKTLIVAAV AASFATVAHA QSSVTLYGVL DAGITYQSNV ATPSGSGKSL WSVGAGVDQS
61: RFGLRGSEDL GGGLKAIFTL ESGFNIGNGR FNNGGGMFNR QAFVGLSSNY GTVTLGRQYD
121: ATQDYLSPLS ATGTWGGTYF AHPLNNDRLN TNGDVAVNNT VKFTSANYAG LQFGGTYSFS
181: NNSQFANNRA YSAGASYQFQ GLKVGAAYSQ ANNAGANTTG ATDPLTGFNI GGTNAASIQG
241: RSRVYGAGAS YAYGPLQGGL LWTQSRLDNL ANGAPTIRAD NYEANVKYNL TPALGLGVAY
301: TYTNAKANGE STHWNQVGVQ ADYALSKRTD VYAQAVYQRS SKNANASIYN GDLSTPFSTS
361: INQTAATVGL RHRF