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|---|---|
| Accession Number: | Q7BCK4 |
| Protein Name: | Outer membrane protein icsA autotransporter |
| Length: | 1102 |
| Molecular Weight: | 116244.00 |
| Species: | [623] |
| Location1 / Topology2 / Orientation3: | Cell outer membrane1 / Multi-pass membrane protein2 |
| Substrate | Virulence factor G |
Cross database links:
| RefSeq: | NP_085346.1 NP_858315.1 |
|---|---|
| Entrez Gene ID: | 1238021 876473 |
| Pfam: | PF03797 PF03212 |
| KEGG: | sfl:CP0182 |
Gene Ontology
GO:0009279
C:cell outer membrane
GO:0009986
C:cell surface
GO:0005576
C:extracellular region
GO:0016021
C:integral to membrane
GO:0042597
C:periplasmic space
GO:0005886
C:plasma membrane
GO:0009405
P:pathogenesis
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References (17)[1] “virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence.” Lett M.-C.et.al. 2644195 [2] “The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri.” Buchrieser C.et.al. 11115111 [3] “Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri.” Venkatesan M.M.et.al. 11292750 [4] “Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence.” Lan R.et.al. 14573649 [5] “Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157.” Jin Q.et.al. 12384590 [6] “Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement.” Goldberg M.B.et.al. 8468279 [7] “Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading.” Fukuda I.et.al. 7896693 [8] “A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri.” Adler B.et.al. 2474742 [9] “Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.” Bernardini M.L.et.al. 2542950 [10] “Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri.” d'Hauteville H.et.al. 1602963 [11] “Extracellular transport of VirG protein in Shigella.” Suzuki T.et.al. 8537341 [12] “Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri.” Suzuki T.et.al. 9582270 [13] “Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility.” Egile C.et.al. 10491394 [14] “The unipolar Shigella surface protein IcsA is targeted directly to the bacterial old pole: IcsP cleavage of IcsA occurs over the entire bacterial surface.” Steinhauer J.et.al. 10231492 [15] “Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and Vibrio.” Charles M.et.al. 11481451 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNQIHKFFCN MTQCSQGGAG ELPTVKEKTC KLSFSPFVVG ASLLLGGPIA FATPLSGTQE 61: LHFSEDNYEK LLTPVDGLSP LGAGEDGMDA WYITSSNPSH ASRTKLRINS DIMISAGHGG 121: AGDNNDGNSC GGNGGDSITG SDLSIINQGM ILGGSGGSGA DHNGDGGEAV TGDNLFIING 181: EIISGGHGGD SYSDSDGGNG GDAVTGVNLP IINKGTISGG NGGNNYGEGD GGNGGDAITG 241: SSLSVINKGT FAGGNGGAAY GYGYDGYGGN AITGDNLSVI NNGAILGGNG GHWGDAINGS 301: NMTIANSGYI ISGKEDDGTQ NVAGNAIHIT GGNNSLILHE GSVITGDVQV NNSSILKIIN 361: NDYTGTTPTI EGDLCAGDCT TVSLSGNKFT VSGDVSFGEN SSLNLAGISS LEASGNMSFG 421: NNVKVEAIIN NWAQKDYKLL SADKGITGFS VSNISIINPL LTTGAIDYTK SYISDQNKLI 481: YGLSWNDTDG DSHGEFNLKE NAELTVSTIL ADNLSHHNIN SWDGKSLTKS GEGTLILAEK 541: NTYSGFTNIN AGILKMGTVE AMTRTAGVIV NKGATLNFSG MNQTVNTLLN SGTVLINNIN 601: APFLPDPVIV TGNMTLEKNG HVILNNSSSN VGQTYVQKGN WHGKGGILSL GAVLGNDNSK 661: TDRLEIAGHA SGITYVAVTN EGGSGDKTLE GVQIISTDSS DKNAFIQKGR IVAGSYDYRL 721: KQGTVSGLNT NKWYLTSQMD NQESKQMSNQ ESTQMSSRRA SSQLVSSLNL GEGSIHTWRP 781: EAGSYIANLI AMNTMFSPSL YDRHGSTIVD PTTGQLSETT MWIRTVGGHN EHNLADRQLK 841: TTANRMVYQI GGDILKTNFT DHDGLHVGIM GAYGYQDSKT HNKYTSYSSR GTVSGYTAGL 901: YSSWFQDEKE RTGLYMDAWL QYSWFNNTVK GDGLTGEKYS SKGITGALEA GYIYPTIRWT 961: AHNNIDNALY LNPQVQITRH GVKANDYIEH NGTMVTSSGG NNIQAKLGLR TSLISQSCID 1021: KETLRKFEPF LEVNWKWSSK QYGVIMNGMS NHQIGNRNVI ELKTGVGGRL ADNLSIWGNV 1081: SQQLGNNSYR DTQGILGVKY TF