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| Accession Number: | Q9EZE7 |
| Protein Name: | Serine protease espC |
| Length: | 1305 |
| Molecular Weight: | 140782.00 |
| Species: | [574521] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Cell outer membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| RefSeq: | YP_002330403.1 |
|---|---|
| Entrez Gene ID: | 7062557 |
| Pfam: | PF03797 PF02395 |
| KEGG: | ecg:E2348C_2915 |
Gene Ontology
GO:0009279
C:cell outer membrane
GO:0009986
C:cell surface
GO:0005576
C:extracellular region
GO:0016021
C:integral to membrane
GO:0042597
C:periplasmic space
GO:0005886
C:plasma membrane
GO:0004252
F:serine-type endopeptidase activity
GO:0009405
P:pathogenesis
GO:0006508
P:proteolysis
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References (5)[1] “Characterization of EspC, a 110-kilodalton protein secreted by enteropathogenic Escherichia coli which is homologous to members of the immunoglobulin A protease-like family of secreted proteins.” Stein M.et.al. 8932311 [2] “EspC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin.” Mellies J.L.et.al. 11119520 [3] “Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.” Iguchi A.et.al. 18952797 [4] “Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells.” Kenny B.et.al. 7644526 [5] “The serine protease motif of EspC from enteropathogenic Escherichia coli produces epithelial damage by a mechanism different from that of Pet toxin from enteroaggregative E. coli.” Navarro-Garcia F.et.al. 15155671
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNKIYALKYC HATGGLIAVS ELASRVMKKA ARGSLLALFN LSLYGAFLSA SQAAQLNIDN 61: VWARDYLDLA QNKGVFKAGA TNVSIQLKNG QTFNFPNVPI PDFSPASNKG ATTSIGGAYS 121: VTATHNGTTH HAISTQNWGQ SSYKYIDRMT NGDFAVTRLD KFVVETTGVK NSVDFSLNSH 181: DALERYGVEI NGEKKIIGFR VGAGTTYTVQ NGNTYSTGQV YNPLLLSASM FQLNWDNKRP 241: YNNTTPFYNE TTGGDSGSGF YLYDNVKKEW VMLGTLFGIA SSGADVWSIL NQYDENTVNG 301: LKNKFTQKVQ LNNNTMSLNS DSFTLAGNNT AVEKNNNNYK DLSFSGGGSI NFDNDVNIGS 361: GGLIFDAGHH YTVTGNNKTF KGAGLDIGDN TTVDWNVKGV VGDNLHKIGA GTLNVNVSQG 421: NNLKTGDGLV VLNSANAFDN IYMASGHGVV KINHSAALNQ NNDYRGIFFT ENGGTLDLNG 481: YDQSFNKIAA TDIGALITNS AVQKAVLSVN NQSNYMYHGS VSGNTEINHQ FDTQKNNSRL 541: ILDGNVDITN DINIKNSQLT MQGHATSHAV FREGGVTCML PGVICEKDYV SGIQQQENSA 601: NKNNNTDYKT NNQVSSFEQP DWENRLFKFK TLNLINSDFI VGRNAIVVGD ISANNSTLSL 661: SGKDTKVHID MYDGKNITGD GFGFRQDIKD GVSVSPESSS YFGNVTLNNH SLLDIGNKFT 721: GGIEAYDSSV SVTSQNAVFD RVGSFVNSSL TLEKGAKLTA QGGIFSTGAV DVKENASLIL 781: TGTPSAQKQE YYSPVISTTE GINLGDKASL SVKNMGYLSS DIHAGTTAAT INLGDGDAET 841: DSPLFSSLMK GYNAVLSGNI TGEQSTVNMN NALWYSDGNS TIGTLKSTGG RVELGGGKDF 901: ATLRVKELNA NNATFLMHTN NSQADQLNVT NKLLGSNNTV LVDFLNKPAS EMNVTLITAP 961: KGSDEKTFTA GTQQIGFSNV TPVISTEKTD DATKWMLTGY QTVSDAGASK TATDFMASGY 1021: KSFLTEVNNL NKRMGDLRDT QGDAGVWARI MNGTGSADGG YSDNYTHVQI GADRKHELDG 1081: VDLFTGALLT YTDSNASSHA FSGKTKSVGG GLYASALFDS GAYFDLIGKY LHHDNQYTAS 1141: FASLGTKDYS SHSWYAGAEV GYRYHLSEES WVEPQMELVY GSVSGKSFSW EDRGMALSMK 1201: DKDYNPLIGR TGVDVGRTFS GDDWKITARA GLGYQFDLLA NGETVLRDAS GEKRFEGEKD 1261: SRMLMNVGMN AEIKDNMRFG LELEKSAFGK YNVDNAINAN FRYSF