1.B.14.1.31 Outer membrane porin, PiuA, of 753 aas. A deficiency of this iron transporter, PiuA in P. aeruginosa, caused 16-fold increases in cefiderocol resistance, suggesting that it contribute to the permeation of cefiderocol into the cell (Ito et al. 2018).
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Accession Number: | O68590 |
Protein Name: | Hydroxamate-type ferrisiderophore receptor |
Length: | 753 |
Molecular Weight: | 82337.00 |
Species: | Pseudomonas aeruginosa [287] |
Location1 / Topology2 / Orientation3: |
Cell outer membrane1 |
Substrate |
cephalosporin |
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1: MSRQSTDTAV SSQRLLASAI GVAITAIAAP QAAQADEAGQ KKTDKDRVLS LDAATIVGEQ
61: QDETTYNVDR SASKKYTAPL LDTPKTVTVI PQQVIKDTGA LTLADALRTT PGITFGAGEG
121: GNPAGDRPFI RGFNAESDTF LDGMRDVASQ TREVFNVEQI EVSKGPGSAY TGAGSTGGSL
181: NLISKTAKQD NFTDAGFTWG SDQTRRTTLD VNRMIGDNAA FRLNLMKHDA HVAGRDEVSV
241: SRWGVAPTVT FGFDTPTRAT LSYYHLSTDD MPDYGLPLTN VNRSKANPSK PASVDRDNFY
301: GLKDRDYRKS TTDSGTFRIE HDLNDNLTLS NSTRLVRTTL DYIVSNPDDS RGNVANGYVY
361: RSAKSRNSTS KGWVNQTDLK ANFETGFIKH TLVTGLEFSY EDVHNRPYAI TSGGGAGNTC
421: NARLLASGDC TSLNRPTPGD NWTGSITDGL AYTDTDTKTS AAYVFDTLKL SEQWELNLGL
481: RYDDFDTKSS GYQTAGRNGP AGYFKRENNS HFWNYQTGLV YKPAPNGSIY LAWSTSSNPT
541: GETGGEGQAD ISVGNNGLDP ERNRNLELGT KWAFFDDALS LNAALFRTDK TNARVASPDV
601: STLQVLDGEQ RVQGVELGFN GKLTEKWKVF GGYTYLDSEI RKSTVKSDEG NKMPQTAQNN
661: FTLWTTYDLL QNFTIGGGTT YVDKQYGNTA NSTYIPSYWR YDAMASYKVS KNVDLQLNVQ
721: NLTDKRYFDQ VYSTHMAHVA PGRTALLGVN FHF