| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.B.2.1.1 | MomP (Omp1) major general porin (transports many small molecules including sugars and amino acids). A transport mechanism and antigenic properties have been studied for the closely related C. pneumoniae protein (Atanu et al. 2013). The ortholog of this protein in Clamydia abortus is likely to be part of the outer membrane complex (COMC) used as a potential vaccine candidate against ovine enzootic abortion (Longbottom et al. 2019). | Bacteria |
Chlamydiota | Omp1 of Chlamydia psittaci |
|
1.B.2.1.2 | Major outer membrance protein MomP (OmpA, Omp1, Omp1L2) of 394 aas; 1 N-terminal TMS Rodríguez-Marañón et al., 2002). This protein is covalently linked to two other cys-rich proteins via disulfide bonds, OmcA (Omp2A; Omp3) with 88 aas and 1 N-terminal TMS, and OmcB (Omp2, Omp2B) with 547 aas and 1 N-terminal TMS. Together these proteins comprise the Chlamydial outer membrane complex (COMC) (Findlay et al. 2005). MOMP is the most suitable substitute for whole cell targets for vaccine production, and its delivery as a combined systemic and mucosal vaccine is most effective (Phillips et al. 2019). It is also a drug target (Sadhasivam et al. 2019). | Bacteria |
Chlamydiota | MomP of Chlamydia trachomatis with two auxiliary proteins, OmcA and OmcB |
|
1.B.2.1.3 | Outer membrane porin, OmpA-A of 259 aas. This protein may be C-terminally truncated since it is substantially smaller than most of the other members of this family. | Bacteria |
Chlamydiota | OmpA-A of Simkania negevensis |
|
1.B.2.1.4 | PorB dicarboxylate-specific porin (Kubo and Stephens 2001). Mutations in porB can give rise to tetracycline resistance (). | Bacteria |
Chlamydiota | PorB of Chlamydia trachomatis |
|
1.B.2.1.5 | Uncharacterized protein of 299 aas and 1 N-terminal TMS. May be C-terminally truncated. | Bacteria |
Myxococcota | UP of Deltaproteobacteria bacterium |
|
1.B.2.1.6 | Uncharacterized protein of 271 aas and 1 N-terminal TMS. | Bacteria |
Pseudomonadota | UP of Thiohalophilus thiocyanatoxydans |
|
1.B.2.1.7 | Uncharacterized protein of 230 aas and 1 N-terminal TMS | Bacteria |
Candidatus Omnitrophota | UP of Candidatus Omnitrophica bacterium |
|
1.B.2.1.8 | Uncharacterized protein of 325 aas and 1 N-terminal TMS. | Bacteria |
Pseudomonadota | UP of unclassified Thioalkalivibrio |