1.B.40.2.5
The trimeric AT adhesin, essential for virulence, SadA (1461 aas). The high resolution structure has been solved using the "dictionary" approach (Hartmann et al. 2012). It's insertion into the outer membrane may be dependent on the BAM complex (TC# 1.B.33) as well as a small inner membrane lipoprotein, SadB (Grin et al. 2013).
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| Accession Number: | E1WDB9 |
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| Protein Name: | Autotransporter |
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| Length: | 1461 |
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| Molecular Weight: | 147838.00 |
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| Species: | Salmonella typhimurium (strain SL1344) [216597] |
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| Number of TMSs: | 1 |
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| Substrate |
protein polypeptide chain |
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1: MNRIFKVLWN AATGTFVVTS ETAKSRGKKN GRRKLAVSAL IGLSSIMVSA DALANAGNDT
61: GDGVTPTGTQ TGGKGWIAIG TDATANTYTN VDGASAAMGY KASAMGKWST AIGSYSQSTG
121: DSSLALGVKS VSAGDRAIAM GASSSASGSY SMAMGVYANS SGAKSVALGY KSVASGATSS
181: ALGYQATASG DDSAAFGNGA KAIGTNSVAL GSGSVAQEDN SVAVGNSTTQ RQITYVAKGD
241: INSTSTDAVT GAQIYSLSQS VADRLGGGAS VNSDGTVNAP LYEVGTGIYN NVGSALSALN
301: TSITNTEASV AGLAEDALLW DESISAFSAS HTGNASKITN LAAGTLAADS TDAVNGSQLF
361: DTNEKVDKNT ADIATNTGSI NQNTADITAN TDSINQNTTD IAANTTSINQ NTTDIATNTT
421: NINSLSDSVT TLTDDALLWD AASGAFSAKH NGSDSKITNL AAGTLAADST DAVNGSQLFD
481: TNEKVDQNTA DITTNTNSIN QNTTDIATNT TNINNLSDSI TTLTDDALLW DAASGAFSAN
541: HNGSASKITN LAAGTLAADS TDAVNGSQLF ATNENVSQNT ADITTNTNSI NQNTTDIATN
601: TTSINNLSDS ITTLTDDALL WDAASGTFSA SRSGSASKIT NLAAGTLAAD STDAVNGSQL
661: YETNQKVDQN TSAIADINTS ITNLSSDNLS WNETTSSFSA SHGSSTTNKI TNVAAGELSE
721: ESTDAVNGSQ LFETNEKVDQ NTTDIAANTT NITQNSTAIE NLNTSVSDIN TSITGLTDNA
781: LLWDEDTGAF SANHGGSTSK ITNVAAGALS EDSTDAVNGS QLYETNQKVD QNTSAIADIN
841: TSITNLGTDA LSWDDEEGAF SASHGTSGTN KITNVAAGEI ASDSTDAVNG SQLYETNMLI
901: SQYNESISQL AGDTSETYIT ENGTGVKYIR TNDNGLEGQD AYATGNGATA VGYDAVASGA
961: GSLALGQNSS SSIEGSIALG SGSTSNRAIT TGIRETSATS DGVVIGYNTT DRELLGALSL
1021: GTDGESYRQI TNVADGSEAQ DAVTVRQLQN AIGAVTTTPT KYYHANSTEE DSLAVGTDSL
1081: AMGAKTIVNA DAGIGIGLNT LVMADAINGI AIGSNARANH ANSIAMGNGS QTTRGAQTDY
1141: TAYNMDTPQN SVGEFSVGSE DGQRQITNVA AGSADTDAVN VGQLKVTDAQ VSRNTQSITN
1201: LNTQVSNLDT RVTNIENGIG DIVTTGSTKY FKTNTDGADA NAQGADSVAI GSGSIAAAEN
1261: SVALGTNSVA DEANTVSVGS STQQRRITNV AAGVNNTDAV NVAQLKASEA GSVRYETNAD
1321: GSVNYSVLNL GDGSGGTTRI GNVSAAVNDT DAVNYAQLKR SVEEANTYTD QKMGEMNSKI
1381: KGVENKMSGG IASAMAMAGL PQAYAPGANM TSIAGGTFNG ESAVAIGVSM VSESGGWVYK
1441: LQGTSNSQGD YSAAIGAGFQ W