Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.6.1.2
OmpF (OprF) porin.  The N-terminal domain has pore activity (Saint et al. 2000).  The protein can exist in multiple conformations of variable conductivities (Nestorovich et al. 2006).  Factors affecting its one-domain open conformer have been studied by Sugawara et al. (2010). OprF is a complement component C3 receptor (Mishra et al. 2015) and is a target of antibacterial drugs (Maccarini et al. 2017). OprF assumes dual conformations and is involved in solute transport, cell envelope integrity, biofilm formation and pathogenesis (Cassin and Tseng 2019). OprF in Pseudomonas aeruginosa is involved in biofilm stimulation by subinhibitory antibiotics (Yaeger et al. 2024).

Accession Number:P13794
Protein Name:PORF aka OmpF aka OprF aka PA1777
Length:350
Molecular Weight:37640.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate molecule

Cross database links:

RefSeq: NP_250468.1   
Entrez Gene ID: 878442   
Pfam: PF00691    PF05736   
BioCyc: PAER208964:PA1777-MONOMER   
KEGG: pae:PA1777   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0006811 P:ion transport
GO:0008360 P:regulation of cell shape

References (2)

[1] “Sequence and transcriptional start site of the Pseudomonas aeruginosa outer membrane porin protein F gene.”  Duchene M.et.al.   2447060
[2] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
Structure:
4RLC   5U1H     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MKLKNTLGVV IGSLVAASAM NAFAQGQNSV EIEAFGKRYF TDSVRNMKNA DLYGGSIGYF 
61:	LTDDVELALS YGEYHDVRGT YETGNKKVHG NLTSLDAIYH FGTPGVGLRP YVSAGLAHQN 
121:	ITNINSDSQG RQQMTMANIG AGLKYYFTEN FFAKASLDGQ YGLEKRDNGH QGEWMAGLGV 
181:	GFNFGGSKAA PAPEPVADVC SDSDNDGVCD NVDKCPDTPA NVTVDANGCP AVAEVVRVQL 
241:	DVKFDFDKSK VKENSYADIK NLADFMKQYP STSTTVEGHT DSVGTDAYNQ KLSERRANAV 
301:	RDVLVNEYGV EGGRVNAVGY GESRPVADNA TAEGRAINRR VEAEVEAEAK