1.B.6.1.24
Omp38; OmpA of 356 aas and 1 N-terminal TMSs. It is a selective antibiotic transporting porin (Iyer et al. 2018; Jyothisri et al. 1999) and induces apoptosis in human cell lines through caspase-dependent and
AIF-dependent pathways. Purified Omp38 enters host cells and localizes to
the mitochondria, which presumably leads to a release of proapoptotic
molecules such as cytochrome c and AIF (apoptosis-inducing factor)
(Choi et al. 2005). It is a virulence factor (Scribano et al. 2024).
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| Accession Number: | Q6RYW5 |
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| Protein Name: | Outer membrane protein Omp38 |
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| Length: | 356 |
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| Molecular Weight: | 38420.00 |
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| Species: | Acinetobacter baumannii [470] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 / Multi-pass membrane protein2 |
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| Substrate |
antimicrobial agent |
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1: MKLSRIALAT MLVAAPLAAA NAGVTVTPLL LGYTFQDSQH NNGGKDGNLT NGPELQDDLF
61: VGAALGIELT PWLGFEAEYN QVKGDVDGAS AGAEYKQKQI NGNFYVTSDL ITKNYDSKIK
121: PYVLLGAGHY KYDFDGVNRG TRGTSEEGTL GNAGVGAFWR LNDALSLRTE ARATYNADEE
181: FWNYTALAGL NVVLGGHLKP AAPVVEVAPV EPTPVAPQPQ ELTEDLNMEL RVFFDTNKSN
241: IKDQYKPEIA KVAEKLSEYP NATARIEGHT DNTGPRKLNE RLSLARANSV KSALVNEYNV
301: DASRLSTQGF AWDQPIADNK TKEGRAMNRR VFATITGSRT VVVQPGQEAA APAAAQ