Thermostable direct hemolysin or Kanagawa haemolysin, TDH, Tdh2, trh of 189 aas. It exhibits monovalent cation selectivity in the order: Cs⁺ > Li⁺ > K⁺ > Rb⁺ > Na⁺, confirming that TDH is the important leak-inducing agent (Huntley and Hall 1994). The crystal structure is known (3A57_A); Ohnishi et al., 2011).  Assembly of a multivalent aptamer efficiently inhibits the thermostable direct hemolysin toxicity induced by Vibrio parahaemolyticus (Chen et al. 2024).