TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.108.1.1









Antimicrobial dermcidin, DCD.  Based on 3-d structural data, dermcidin forms an architecture of high-conductance transmembrane channels, composed of zinc-connected trimers of antiparallel helix pairs. Molecular dynamics simulations elucidated the unusual membrane permeation pathway for ions and showed adjustment of the pore to various membranes (Song et al. 2013). DCD assembles in solution into a hexameric pre-channel complex before  targeting the membrane and integration, the complex follows a deviation of the barrel stave model (Zeth and Sancho-Vaello 2017). The tilt angle and the conductance is determined by the membrane thickness and the cholesterol composition (Song et al. 2019). A soluble 48 residue fragment has been structurally characterized (PDB: 2KSG_A). Membrane interactions and pore formation have been investigated for α-helical AMPs leading to the formulation of three basic mechanistic models: the barrel stave, toroidal, and carpet models. Human cathelicidin (LL-37) and dermcidin (DCD) are α-helical, and their structures have been solved at atomic resolution. DCD assembles in solution into a hexameric pre-channel complex before  actual membrane targeting and integration steps occur, and the complex follows a deviation of the barrel stave model (Zeth and Sancho-Vaello 2017).

Eukaryota
Metazoa, Chordata
Dermcidin of Homo sapiens
1.C.108.2.1









Lacritin of 137 aas and 1 N-terminal TMS.  The crystal structure is available for the C-terminal 48 aas (2KSG A).

Eukaryota
Metazoa, Chordata
Lacritin of Pongo abelii
1.C.108.2.2









Extracellular glycoprotein lacritin-like isoform X2 of 111 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
Lacritin-like peptide of Equus przewalskii
1.C.108.2.3









Extracellular glycoprotein lacritin isoform X1of 119 aas and 1 N-terminal TM

Eukaryota
Metazoa, Chordata
Lacritin-like protein of Acinonyx jubatus
1.C.108.2.4









Extracellular glycoprotein lacritin of 109 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
lacritin of Myotis lucifugus
1.C.108.3.1









Hypothetical protein

Eukaryota
Metazoa, Chordata
HP of Homo sapiens